Rheological Considerations of Pharmaceutical Formulations: Focus on Viscoelasticity
Controlling rheological properties offers the opportunity to gain insight into the physical characteristics, structure, stability and drug release rate of formulations. To better understand the physical properties of hydrogels, not only rotational but also oscillatory experiments should be performed...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/9/6/469 |
| _version_ | 1797594634604511232 |
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| author | Lívia Budai Marianna Budai Zsófia Edit Fülöpné Pápay Zsófia Vilimi István Antal |
| author_facet | Lívia Budai Marianna Budai Zsófia Edit Fülöpné Pápay Zsófia Vilimi István Antal |
| author_sort | Lívia Budai |
| collection | DOAJ |
| description | Controlling rheological properties offers the opportunity to gain insight into the physical characteristics, structure, stability and drug release rate of formulations. To better understand the physical properties of hydrogels, not only rotational but also oscillatory experiments should be performed. Viscoelastic properties, including elastic and viscous properties, are measured using oscillatory rheology. The gel strength and elasticity of hydrogels are of great importance for pharmaceutical development as the application of viscoelastic preparations has considerably expanded in recent decades. Viscosupplementation, ophthalmic surgery and tissue engineering are just a few examples from the wide range of possible applications of viscoelastic hydrogels. Hyaluronic acid, alginate, gellan gum, pectin and chitosan are remarkable representatives of gelling agents that attract great attention applied in biomedical fields. This review provides a brief summary of rheological properties, highlighting the viscoelasticity of hydrogels with great potential in biomedicine. |
| first_indexed | 2024-03-11T02:26:04Z |
| format | Article |
| id | doaj.art-18dd76de1229426c810c42f902b3d9f0 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-11T02:26:04Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-18dd76de1229426c810c42f902b3d9f02023-11-18T10:32:22ZengMDPI AGGels2310-28612023-06-019646910.3390/gels9060469Rheological Considerations of Pharmaceutical Formulations: Focus on ViscoelasticityLívia Budai0Marianna Budai1Zsófia Edit Fülöpné Pápay2Zsófia Vilimi3István Antal4Department of Pharmaceutics, Semmelweis University, 1092 Budapest, HungaryDepartment of Pharmaceutics, Semmelweis University, 1092 Budapest, HungaryDepartment of Pharmaceutics, Semmelweis University, 1092 Budapest, HungaryDepartment of Pharmaceutics, Semmelweis University, 1092 Budapest, HungaryDepartment of Pharmaceutics, Semmelweis University, 1092 Budapest, HungaryControlling rheological properties offers the opportunity to gain insight into the physical characteristics, structure, stability and drug release rate of formulations. To better understand the physical properties of hydrogels, not only rotational but also oscillatory experiments should be performed. Viscoelastic properties, including elastic and viscous properties, are measured using oscillatory rheology. The gel strength and elasticity of hydrogels are of great importance for pharmaceutical development as the application of viscoelastic preparations has considerably expanded in recent decades. Viscosupplementation, ophthalmic surgery and tissue engineering are just a few examples from the wide range of possible applications of viscoelastic hydrogels. Hyaluronic acid, alginate, gellan gum, pectin and chitosan are remarkable representatives of gelling agents that attract great attention applied in biomedical fields. This review provides a brief summary of rheological properties, highlighting the viscoelasticity of hydrogels with great potential in biomedicine.https://www.mdpi.com/2310-2861/9/6/469viscoelastic geloscillatory rheologyviscosityelastic and viscous modulibiomedicine |
| spellingShingle | Lívia Budai Marianna Budai Zsófia Edit Fülöpné Pápay Zsófia Vilimi István Antal Rheological Considerations of Pharmaceutical Formulations: Focus on Viscoelasticity Gels viscoelastic gel oscillatory rheology viscosity elastic and viscous moduli biomedicine |
| title | Rheological Considerations of Pharmaceutical Formulations: Focus on Viscoelasticity |
| title_full | Rheological Considerations of Pharmaceutical Formulations: Focus on Viscoelasticity |
| title_fullStr | Rheological Considerations of Pharmaceutical Formulations: Focus on Viscoelasticity |
| title_full_unstemmed | Rheological Considerations of Pharmaceutical Formulations: Focus on Viscoelasticity |
| title_short | Rheological Considerations of Pharmaceutical Formulations: Focus on Viscoelasticity |
| title_sort | rheological considerations of pharmaceutical formulations focus on viscoelasticity |
| topic | viscoelastic gel oscillatory rheology viscosity elastic and viscous moduli biomedicine |
| url | https://www.mdpi.com/2310-2861/9/6/469 |
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