Influence of ABO blood group on susceptibility to different pathological types of lung cancer: a retrospective study
Abstract Purpose Current research has shown a link between ABO blood group and many diseases. The purpose of this study aimed to investigate the influence of the ABO blood group on the risk of developing different pathological types of lung cancer. Materials and methods This retrospective study was...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-022-02845-2 |
| _version_ | 1811204174987132928 |
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| author | Haotian Yang Xianjun Zeng Yu Zhang Weilai Tong Geliang Yao Chunyu Lan Jiaming Liu Zhili Liu Nanshan Zhong |
| author_facet | Haotian Yang Xianjun Zeng Yu Zhang Weilai Tong Geliang Yao Chunyu Lan Jiaming Liu Zhili Liu Nanshan Zhong |
| author_sort | Haotian Yang |
| collection | DOAJ |
| description | Abstract Purpose Current research has shown a link between ABO blood group and many diseases. The purpose of this study aimed to investigate the influence of the ABO blood group on the risk of developing different pathological types of lung cancer. Materials and methods This retrospective study was composed of 7681 patients with lung cancer and 12, 671 non-lung cancer patients who were admitted to the First Affiliated Hospital of Nanchang University from January 2016 to January 2021. The subjects with lung cancer were grouped into small cell lung cancer group (n = 725), lung adenocarcinoma group (n = 4520), and lung squamous cell carcinoma group (n = 2286) according to pathological types. The ABO blood group distribution of each lung cancer type group was compared with that of the control group. Statistical analysis was determined with chi-square and logistic regression. Results Univariate analysis showed that the ABO blood group distribution of lung adenocarcinoma, lung squamous cell carcinoma, and small cell lung cancer was different from that of the control group (P < 0.01). After adjusting for age, sex, smoking history, and drinking history, logistic regression analysis showed that the risk of lung adenocarcinoma in blood type O was higher than that in blood type A (P < 0.01). There was no significant difference in ABO blood group composition between small cell lung cancer group, lung squamous cell carcinoma group, and control group (P > 0.05). In addition, gender and age have an influence on all three types of lung cancer (P < 0.01). Smoking was a risk factor in lung squamous cell carcinoma and small cell carcinoma (P < 0.01). Alcohol consumption was a risk factor in lung adenocarcinoma (P < 0.01). Conclusion ABO blood group may be correlated with the occurrence of lung adenocarcinoma in Jiangxi province, but not with lung squamous cell carcinoma and small cell carcinoma. |
| first_indexed | 2024-04-12T03:06:54Z |
| format | Article |
| id | doaj.art-18df22627e7c40e5bf0362a79a4cfe5a |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-04-12T03:06:54Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-18df22627e7c40e5bf0362a79a4cfe5a2022-12-22T03:50:28ZengBMCWorld Journal of Surgical Oncology1477-78192022-12-012011710.1186/s12957-022-02845-2Influence of ABO blood group on susceptibility to different pathological types of lung cancer: a retrospective studyHaotian Yang0Xianjun Zeng1Yu Zhang2Weilai Tong3Geliang Yao4Chunyu Lan5Jiaming Liu6Zhili Liu7Nanshan Zhong8Medical Innovation Center, The First Affiliated Hospital of Nanchang UniversityDepartment of Information, The First Affiliated Hospital of Nanchang UniversityMedical Innovation Center, The First Affiliated Hospital of Nanchang UniversityMedical Innovation Center, The First Affiliated Hospital of Nanchang UniversityMedical Innovation Center, The First Affiliated Hospital of Nanchang UniversityDepartment of Information, The First Affiliated Hospital of Nanchang UniversityInstitute of Spine and Spinal Cord, Nanchang UniversityInstitute of Spine and Spinal Cord, Nanchang UniversityMedical Innovation Center, The First Affiliated Hospital of Nanchang UniversityAbstract Purpose Current research has shown a link between ABO blood group and many diseases. The purpose of this study aimed to investigate the influence of the ABO blood group on the risk of developing different pathological types of lung cancer. Materials and methods This retrospective study was composed of 7681 patients with lung cancer and 12, 671 non-lung cancer patients who were admitted to the First Affiliated Hospital of Nanchang University from January 2016 to January 2021. The subjects with lung cancer were grouped into small cell lung cancer group (n = 725), lung adenocarcinoma group (n = 4520), and lung squamous cell carcinoma group (n = 2286) according to pathological types. The ABO blood group distribution of each lung cancer type group was compared with that of the control group. Statistical analysis was determined with chi-square and logistic regression. Results Univariate analysis showed that the ABO blood group distribution of lung adenocarcinoma, lung squamous cell carcinoma, and small cell lung cancer was different from that of the control group (P < 0.01). After adjusting for age, sex, smoking history, and drinking history, logistic regression analysis showed that the risk of lung adenocarcinoma in blood type O was higher than that in blood type A (P < 0.01). There was no significant difference in ABO blood group composition between small cell lung cancer group, lung squamous cell carcinoma group, and control group (P > 0.05). In addition, gender and age have an influence on all three types of lung cancer (P < 0.01). Smoking was a risk factor in lung squamous cell carcinoma and small cell carcinoma (P < 0.01). Alcohol consumption was a risk factor in lung adenocarcinoma (P < 0.01). Conclusion ABO blood group may be correlated with the occurrence of lung adenocarcinoma in Jiangxi province, but not with lung squamous cell carcinoma and small cell carcinoma.https://doi.org/10.1186/s12957-022-02845-2ABO blood groupLung cancerDifferent pathological typesLogistic regression |
| spellingShingle | Haotian Yang Xianjun Zeng Yu Zhang Weilai Tong Geliang Yao Chunyu Lan Jiaming Liu Zhili Liu Nanshan Zhong Influence of ABO blood group on susceptibility to different pathological types of lung cancer: a retrospective study World Journal of Surgical Oncology ABO blood group Lung cancer Different pathological types Logistic regression |
| title | Influence of ABO blood group on susceptibility to different pathological types of lung cancer: a retrospective study |
| title_full | Influence of ABO blood group on susceptibility to different pathological types of lung cancer: a retrospective study |
| title_fullStr | Influence of ABO blood group on susceptibility to different pathological types of lung cancer: a retrospective study |
| title_full_unstemmed | Influence of ABO blood group on susceptibility to different pathological types of lung cancer: a retrospective study |
| title_short | Influence of ABO blood group on susceptibility to different pathological types of lung cancer: a retrospective study |
| title_sort | influence of abo blood group on susceptibility to different pathological types of lung cancer a retrospective study |
| topic | ABO blood group Lung cancer Different pathological types Logistic regression |
| url | https://doi.org/10.1186/s12957-022-02845-2 |
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