The effects of probiotic administration on patients with prediabetes: a meta-analysis and systematic review
Abstract Background This paper aimed to examine the effects of probiotics on eight factors in the prediabetic population by meta-analysis, namely, fasting blood glucose (FBG), glycated haemoglobin A1c (HbA1c), homeostatic model assessment of insulin resistance (HOMA-IR), quantitative insulin sensiti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-022-03695-y |
| _version_ | 1798044485096046592 |
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| author | Ya Li You Wu Lili Wu Lingling Qin Tonghua Liu |
| author_facet | Ya Li You Wu Lili Wu Lingling Qin Tonghua Liu |
| author_sort | Ya Li |
| collection | DOAJ |
| description | Abstract Background This paper aimed to examine the effects of probiotics on eight factors in the prediabetic population by meta-analysis, namely, fasting blood glucose (FBG), glycated haemoglobin A1c (HbA1c), homeostatic model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), and the mechanisms of action are summarized from the existing studies. Methods Seven databases (PubMed, Web of Science, Embase, Cochrane Library, SinoMed, CNKI, and Wanfang Med) were searched until March 2022. Review Manager 5.4 was used for meta-analysis. The data were analysed using weighted mean differences (WMDs) or standardized mean differences (SMDs) under a fixed effect model to observe the efficacy of probiotic supplementation on the included indicators. Results Seven publications with a total of 460 patients were included. According to the meta-analysis, probiotics were able to significantly decrease the levels of HbA1c (WMD, -0.07; 95% CI -0.11, -0.03; P = 0.001), QUICKI (WMD, 0.01; 95% CI 0.00, 0.02; P = 0.04), TC (SMD, -0.28; 95% CI -0.53, -0.22; P = 0.03), TG (SMD, -0.26; 95% CI -0.52, -0.01; P = 0.04), and LDL-C (WMD, -8.94; 95% CI -14.91, -2.97; P = 0.003) compared to levels in the placebo group. The effects on FBG (WMD, -0.53; 95% CI -2.31, 1.25; P = 0.56), HOMA-IR (WMD, -0.21; 95% CI -0.45, 0.04; P = 0.10), and HDL-C (WMD, 2.05; 95% CI -0.28, 4.38; P = 0.08) were not different from those of the placebo group. Conclusion The present study clearly indicated that probiotics may fulfil an important role in the regulation of HbA1c, QUICKI, TC, TG and LDL-C in patients with prediabetes. In addition, based on existing studies, we concluded that probiotics may regulate blood glucose homeostasis in a variety of ways. Trial Registration This meta-analysis has been registered at PROSPERO with ID: CRD42022321995. |
| first_indexed | 2024-04-11T23:05:55Z |
| format | Article |
| id | doaj.art-18df7794569c48b5829ab067225738c9 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-11T23:05:55Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-18df7794569c48b5829ab067225738c92022-12-22T03:58:01ZengBMCJournal of Translational Medicine1479-58762022-11-0120111310.1186/s12967-022-03695-yThe effects of probiotic administration on patients with prediabetes: a meta-analysis and systematic reviewYa Li0You Wu1Lili Wu2Lingling Qin3Tonghua Liu4Key Laboratory of Health Cultivation of the Ministry of Education, Beijing University of Chinese MedicineKey Laboratory of Health Cultivation of the Ministry of Education, Beijing University of Chinese MedicineKey Laboratory of Health Cultivation of the Ministry of Education, Beijing University of Chinese MedicineKey Laboratory of Health Cultivation of the Ministry of Education, Beijing University of Chinese MedicineKey Laboratory of Health Cultivation of the Ministry of Education, Beijing University of Chinese MedicineAbstract Background This paper aimed to examine the effects of probiotics on eight factors in the prediabetic population by meta-analysis, namely, fasting blood glucose (FBG), glycated haemoglobin A1c (HbA1c), homeostatic model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), and the mechanisms of action are summarized from the existing studies. Methods Seven databases (PubMed, Web of Science, Embase, Cochrane Library, SinoMed, CNKI, and Wanfang Med) were searched until March 2022. Review Manager 5.4 was used for meta-analysis. The data were analysed using weighted mean differences (WMDs) or standardized mean differences (SMDs) under a fixed effect model to observe the efficacy of probiotic supplementation on the included indicators. Results Seven publications with a total of 460 patients were included. According to the meta-analysis, probiotics were able to significantly decrease the levels of HbA1c (WMD, -0.07; 95% CI -0.11, -0.03; P = 0.001), QUICKI (WMD, 0.01; 95% CI 0.00, 0.02; P = 0.04), TC (SMD, -0.28; 95% CI -0.53, -0.22; P = 0.03), TG (SMD, -0.26; 95% CI -0.52, -0.01; P = 0.04), and LDL-C (WMD, -8.94; 95% CI -14.91, -2.97; P = 0.003) compared to levels in the placebo group. The effects on FBG (WMD, -0.53; 95% CI -2.31, 1.25; P = 0.56), HOMA-IR (WMD, -0.21; 95% CI -0.45, 0.04; P = 0.10), and HDL-C (WMD, 2.05; 95% CI -0.28, 4.38; P = 0.08) were not different from those of the placebo group. Conclusion The present study clearly indicated that probiotics may fulfil an important role in the regulation of HbA1c, QUICKI, TC, TG and LDL-C in patients with prediabetes. In addition, based on existing studies, we concluded that probiotics may regulate blood glucose homeostasis in a variety of ways. Trial Registration This meta-analysis has been registered at PROSPERO with ID: CRD42022321995.https://doi.org/10.1186/s12967-022-03695-yPrediabetesProbioticsRandom control trialsMeta-analysisSystematic review |
| spellingShingle | Ya Li You Wu Lili Wu Lingling Qin Tonghua Liu The effects of probiotic administration on patients with prediabetes: a meta-analysis and systematic review Journal of Translational Medicine Prediabetes Probiotics Random control trials Meta-analysis Systematic review |
| title | The effects of probiotic administration on patients with prediabetes: a meta-analysis and systematic review |
| title_full | The effects of probiotic administration on patients with prediabetes: a meta-analysis and systematic review |
| title_fullStr | The effects of probiotic administration on patients with prediabetes: a meta-analysis and systematic review |
| title_full_unstemmed | The effects of probiotic administration on patients with prediabetes: a meta-analysis and systematic review |
| title_short | The effects of probiotic administration on patients with prediabetes: a meta-analysis and systematic review |
| title_sort | effects of probiotic administration on patients with prediabetes a meta analysis and systematic review |
| topic | Prediabetes Probiotics Random control trials Meta-analysis Systematic review |
| url | https://doi.org/10.1186/s12967-022-03695-y |
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