Decreased serum levels of thrombospondin‐1 in female depressed patients
Abstract Aim Thrombospondin‐1 (TSP‐1) is an astrocyte‐derived synaptogenesis‐related factor. It was previously reported to be increased by chronic treatment of electroconvulsive seizure, a model of electroconvulsive therapy (ECT), in rat hippocampus. The aim of this study was to examine whether seru...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-03-01
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| Series: | Neuropsychopharmacology Reports |
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| Online Access: | https://doi.org/10.1002/npr2.12088 |
| _version_ | 1828277266881183744 |
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| author | Mami Okada‐Tsuchioka Wataru Omori Naoto Kajitani Chiyo Shibasaki Kei Itagaki Minoru Takebayashi |
| author_facet | Mami Okada‐Tsuchioka Wataru Omori Naoto Kajitani Chiyo Shibasaki Kei Itagaki Minoru Takebayashi |
| author_sort | Mami Okada‐Tsuchioka |
| collection | DOAJ |
| description | Abstract Aim Thrombospondin‐1 (TSP‐1) is an astrocyte‐derived synaptogenesis‐related factor. It was previously reported to be increased by chronic treatment of electroconvulsive seizure, a model of electroconvulsive therapy (ECT), in rat hippocampus. The aim of this study was to examine whether serum levels of TSP‐1 are associated with depression and ECT. Methods Serum TSP‐1 levels of major depressive disorder (MDD) patients (n = 36) and age‐ and gender‐matched healthy controls (n = 36) were measured by TSP‐1 ELISA. MDD patients were diagnosed according to the Diagnostics and Statistical Manual of Mental Disorders‐IV‐TR and underwent ECT. MDD patients were also analyzed for serum TSP‐1 levels pre‐ and post‐ECT. Evaluation of symptoms was obtained using the Hamilton Rating Scale for Depression. Results Serum TSP‐1 levels showed significant decreases specific to female MDD patients. However, TSP‐1 did not change pre‐ and post‐ECT, did not correlate with symptoms, nor was not affected by the dose of antidepressants. Conclusion Serum TSP‐1 is a possible female‐specific factor that reflects depressive trait, but not state. |
| first_indexed | 2024-04-13T07:11:59Z |
| format | Article |
| id | doaj.art-18e0c9e16de74086ba28183f179e08b4 |
| institution | Directory Open Access Journal |
| issn | 2574-173X |
| language | English |
| last_indexed | 2024-04-13T07:11:59Z |
| publishDate | 2020-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuropsychopharmacology Reports |
| spelling | doaj.art-18e0c9e16de74086ba28183f179e08b42022-12-22T02:56:51ZengWileyNeuropsychopharmacology Reports2574-173X2020-03-01401394510.1002/npr2.12088Decreased serum levels of thrombospondin‐1 in female depressed patientsMami Okada‐Tsuchioka0Wataru Omori1Naoto Kajitani2Chiyo Shibasaki3Kei Itagaki4Minoru Takebayashi5Division of Psychiatry and Neuroscience Institute for Clinical Research National Hospital Organization Kure Medical Center and Chugoku Cancer Center Kure JapanDivision of Psychiatry and Neuroscience Institute for Clinical Research National Hospital Organization Kure Medical Center and Chugoku Cancer Center Kure JapanDivision of Psychiatry and Neuroscience Institute for Clinical Research National Hospital Organization Kure Medical Center and Chugoku Cancer Center Kure JapanDivision of Psychiatry and Neuroscience Institute for Clinical Research National Hospital Organization Kure Medical Center and Chugoku Cancer Center Kure JapanDivision of Psychiatry and Neuroscience Institute for Clinical Research National Hospital Organization Kure Medical Center and Chugoku Cancer Center Kure JapanDivision of Psychiatry and Neuroscience Institute for Clinical Research National Hospital Organization Kure Medical Center and Chugoku Cancer Center Kure JapanAbstract Aim Thrombospondin‐1 (TSP‐1) is an astrocyte‐derived synaptogenesis‐related factor. It was previously reported to be increased by chronic treatment of electroconvulsive seizure, a model of electroconvulsive therapy (ECT), in rat hippocampus. The aim of this study was to examine whether serum levels of TSP‐1 are associated with depression and ECT. Methods Serum TSP‐1 levels of major depressive disorder (MDD) patients (n = 36) and age‐ and gender‐matched healthy controls (n = 36) were measured by TSP‐1 ELISA. MDD patients were diagnosed according to the Diagnostics and Statistical Manual of Mental Disorders‐IV‐TR and underwent ECT. MDD patients were also analyzed for serum TSP‐1 levels pre‐ and post‐ECT. Evaluation of symptoms was obtained using the Hamilton Rating Scale for Depression. Results Serum TSP‐1 levels showed significant decreases specific to female MDD patients. However, TSP‐1 did not change pre‐ and post‐ECT, did not correlate with symptoms, nor was not affected by the dose of antidepressants. Conclusion Serum TSP‐1 is a possible female‐specific factor that reflects depressive trait, but not state.https://doi.org/10.1002/npr2.12088depressionelectroconvulsive therapyfemale‐specificserumthrombospondin‐1 |
| spellingShingle | Mami Okada‐Tsuchioka Wataru Omori Naoto Kajitani Chiyo Shibasaki Kei Itagaki Minoru Takebayashi Decreased serum levels of thrombospondin‐1 in female depressed patients Neuropsychopharmacology Reports depression electroconvulsive therapy female‐specific serum thrombospondin‐1 |
| title | Decreased serum levels of thrombospondin‐1 in female depressed patients |
| title_full | Decreased serum levels of thrombospondin‐1 in female depressed patients |
| title_fullStr | Decreased serum levels of thrombospondin‐1 in female depressed patients |
| title_full_unstemmed | Decreased serum levels of thrombospondin‐1 in female depressed patients |
| title_short | Decreased serum levels of thrombospondin‐1 in female depressed patients |
| title_sort | decreased serum levels of thrombospondin 1 in female depressed patients |
| topic | depression electroconvulsive therapy female‐specific serum thrombospondin‐1 |
| url | https://doi.org/10.1002/npr2.12088 |
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