Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19
COVID-19 in immunocompromised patients is difficult to treat. SARS-CoV-2 interaction with the host immune system and the role of therapy still remains only partly understood. There are no data regarding the use of monoclonal antibodies and the combination of two antivirals in fighting viral replicat...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1062450/full |
| _version_ | 1797957665316405248 |
|---|---|
| author | Federico Baldi Federico Baldi Chiara Dentone Malgorzata Mikulska Malgorzata Mikulska Daniela Fenoglio Daniela Fenoglio Michele Mirabella Federica Magnè Federica Portunato Tiziana Altosole Chiara Sepulcri Chiara Sepulcri Daniele Roberto Giacobbe Daniele Roberto Giacobbe Chiara Uras Graziana Scavone Lucia Taramasso Andrea Orsi Andrea Orsi Giuseppe Cittadini Gilberto Filaci Gilberto Filaci Matteo Bassetti Matteo Bassetti |
| author_facet | Federico Baldi Federico Baldi Chiara Dentone Malgorzata Mikulska Malgorzata Mikulska Daniela Fenoglio Daniela Fenoglio Michele Mirabella Federica Magnè Federica Portunato Tiziana Altosole Chiara Sepulcri Chiara Sepulcri Daniele Roberto Giacobbe Daniele Roberto Giacobbe Chiara Uras Graziana Scavone Lucia Taramasso Andrea Orsi Andrea Orsi Giuseppe Cittadini Gilberto Filaci Gilberto Filaci Matteo Bassetti Matteo Bassetti |
| author_sort | Federico Baldi |
| collection | DOAJ |
| description | COVID-19 in immunocompromised patients is difficult to treat. SARS-CoV-2 interaction with the host immune system and the role of therapy still remains only partly understood. There are no data regarding the use of monoclonal antibodies and the combination of two antivirals in fighting viral replication and disease progression. We report the cases of two patients, both treated with rituximab for non-Hodgkin lymphoma and granulomatosis with polyangiitis, respectively, and both hospitalized for COVID-19 with positive SARS-CoV-2 RNAemia, who were successfully treated with a salvage combination therapy with sotrovimab, remdesivir and nirmatrelvir/ritonavir. |
| first_indexed | 2024-04-11T00:07:21Z |
| format | Article |
| id | doaj.art-18e221ec483d41f48a5899c3d261f260 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T00:07:21Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-18e221ec483d41f48a5899c3d261f2602023-01-09T09:00:43ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-01-01910.3389/fmed.2022.10624501062450Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19Federico Baldi0Federico Baldi1Chiara Dentone2Malgorzata Mikulska3Malgorzata Mikulska4Daniela Fenoglio5Daniela Fenoglio6Michele Mirabella7Federica Magnè8Federica Portunato9Tiziana Altosole10Chiara Sepulcri11Chiara Sepulcri12Daniele Roberto Giacobbe13Daniele Roberto Giacobbe14Chiara Uras15Graziana Scavone16Lucia Taramasso17Andrea Orsi18Andrea Orsi19Giuseppe Cittadini20Gilberto Filaci21Gilberto Filaci22Matteo Bassetti23Matteo Bassetti24Department of Health Sciences (DISSAL), University of Genoa, Genoa, ItalyInfectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, ItalyInfectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, ItalyDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, ItalyInfectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, ItalyDepartment of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, ItalyBiotherapy Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, ItalyInfectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, ItalyInfectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, ItalyInfectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, ItalyDepartment of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, ItalyDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, ItalyInfectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, ItalyDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, ItalyInfectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, ItalyDepartment of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, ItalyBiotherapy Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, ItalyInfectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, ItalyDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, ItalyHygiene Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, ItalyGeneral Radiology, Polyclinic San Martino Hospital, IRCCS for Oncology and Neuroscience, Genoa, ItalyDepartment of Internal Medicine, Centre of Excellence for Biomedical Research, University of Genoa, Genoa, ItalyBiotherapy Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, ItalyDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, ItalyInfectious Diseases Unit, Polyclinic San Martino Hospital (IRCCS), Genoa, ItalyCOVID-19 in immunocompromised patients is difficult to treat. SARS-CoV-2 interaction with the host immune system and the role of therapy still remains only partly understood. There are no data regarding the use of monoclonal antibodies and the combination of two antivirals in fighting viral replication and disease progression. We report the cases of two patients, both treated with rituximab for non-Hodgkin lymphoma and granulomatosis with polyangiitis, respectively, and both hospitalized for COVID-19 with positive SARS-CoV-2 RNAemia, who were successfully treated with a salvage combination therapy with sotrovimab, remdesivir and nirmatrelvir/ritonavir.https://www.frontiersin.org/articles/10.3389/fmed.2022.1062450/fullsalvage therapyCOVID-19immunocompromisedmonoclonal antibodiessotrovimabnirmatrelvir/ritonavir |
| spellingShingle | Federico Baldi Federico Baldi Chiara Dentone Malgorzata Mikulska Malgorzata Mikulska Daniela Fenoglio Daniela Fenoglio Michele Mirabella Federica Magnè Federica Portunato Tiziana Altosole Chiara Sepulcri Chiara Sepulcri Daniele Roberto Giacobbe Daniele Roberto Giacobbe Chiara Uras Graziana Scavone Lucia Taramasso Andrea Orsi Andrea Orsi Giuseppe Cittadini Gilberto Filaci Gilberto Filaci Matteo Bassetti Matteo Bassetti Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19 Frontiers in Medicine salvage therapy COVID-19 immunocompromised monoclonal antibodies sotrovimab nirmatrelvir/ritonavir |
| title | Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19 |
| title_full | Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19 |
| title_fullStr | Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19 |
| title_full_unstemmed | Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19 |
| title_short | Case report: Sotrovimab, remdesivir and nirmatrelvir/ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for COVID-19 |
| title_sort | case report sotrovimab remdesivir and nirmatrelvir ritonavir combination as salvage treatment option in two immunocompromised patients hospitalized for covid 19 |
| topic | salvage therapy COVID-19 immunocompromised monoclonal antibodies sotrovimab nirmatrelvir/ritonavir |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1062450/full |
| work_keys_str_mv | AT federicobaldi casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT federicobaldi casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT chiaradentone casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT malgorzatamikulska casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT malgorzatamikulska casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT danielafenoglio casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT danielafenoglio casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT michelemirabella casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT federicamagne casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT federicaportunato casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT tizianaaltosole casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT chiarasepulcri casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT chiarasepulcri casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT danielerobertogiacobbe casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT danielerobertogiacobbe casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT chiarauras casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT grazianascavone casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT luciataramasso casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT andreaorsi casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT andreaorsi casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT giuseppecittadini casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT gilbertofilaci casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT gilbertofilaci casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT matteobassetti casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 AT matteobassetti casereportsotrovimabremdesivirandnirmatrelvirritonavircombinationassalvagetreatmentoptionintwoimmunocompromisedpatientshospitalizedforcovid19 |