A novel model for predicting the prognosis of postoperative intrahepatic cholangiocarcinoma patients
Abstract Intrahepatic cholangiocarcinoma (ICC) accounts for 20% of liver malignancies with a 5-year survival rate of 35% at best with limited prognostic predictors. Lung Immune Prognostic Index (LIPI) is a novel prognostic factor in pulmonary cancers. In this study, we developed a modified prognosti...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-45056-9 |
| _version_ | 1797630287215067136 |
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| author | Yinghao Lv Hu Liu Penghui He Sinan Xie Xiuchun Yin Yunshi Cai Hong Wu |
| author_facet | Yinghao Lv Hu Liu Penghui He Sinan Xie Xiuchun Yin Yunshi Cai Hong Wu |
| author_sort | Yinghao Lv |
| collection | DOAJ |
| description | Abstract Intrahepatic cholangiocarcinoma (ICC) accounts for 20% of liver malignancies with a 5-year survival rate of 35% at best with limited prognostic predictors. Lung Immune Prognostic Index (LIPI) is a novel prognostic factor in pulmonary cancers. In this study, we developed a modified prognostic model from LIPI called intrahepatic immune prognostic index (IIPI) for ICC. A retrospectively study was conducted at Liver Transplant Center of West China Hospital between January 2015 and January 2023. Hematological factors and clinical features of ICC patients were collected and analyzed. The area under curve (AUC) and optimal cuff-off of each single hematological factor was calculated. In this study, derived neurtrophil to lymphocyte ratio (dNLR), arbohydrate antigen199 (CA199) and carcinoembryonic antigen (CEA) have higher AUC values. LIPI was composed of dNLR and was further modified by combing CA199 and CEA, forming the IIPI. The IIPI consists of four grades which are None, Light, Moderate and Severe. Compared to other prognostic factors, IIPI exhibited better ability to predict overall survival. The multivariate analysis indicated that cirrhosis, differentiation, hilar invasion and IIPI were independent prognostic factors for ICC patients. An IIPI-based nomogram was also established and could predict the overall survival. In addition, the subgroup analyses based on clinical prognostic factors showed that the IIPI exhibited excellent prognostic influence. IIPI model is suitable for predicting the prognosis of postoperative ICC patients. Further research is needed to explore the relationship between postoperative recurrence and metastasis of ICC patients and IIPI. |
| first_indexed | 2024-03-11T11:05:02Z |
| format | Article |
| id | doaj.art-18e2ea9fffde4e2ebc37051441356e71 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-11T11:05:02Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-18e2ea9fffde4e2ebc37051441356e712023-11-12T12:13:29ZengNature PortfolioScientific Reports2045-23222023-11-0113111010.1038/s41598-023-45056-9A novel model for predicting the prognosis of postoperative intrahepatic cholangiocarcinoma patientsYinghao Lv0Hu Liu1Penghui He2Sinan Xie3Xiuchun Yin4Yunshi Cai5Hong Wu6Liver Transplant Center, Transplant Center, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Sichuan UniversityLiver Transplant Center, Transplant Center, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Sichuan UniversityLiver Transplant Center, Transplant Center, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Sichuan UniversityLiver Transplant Center, Transplant Center, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Sichuan UniversityWard of Liver Transplant Centre and Vascular Surgery, West China Hospital, Sichuan UniversityLiver Transplant Center, Transplant Center, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Sichuan UniversityLiver Transplant Center, Transplant Center, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Sichuan UniversityAbstract Intrahepatic cholangiocarcinoma (ICC) accounts for 20% of liver malignancies with a 5-year survival rate of 35% at best with limited prognostic predictors. Lung Immune Prognostic Index (LIPI) is a novel prognostic factor in pulmonary cancers. In this study, we developed a modified prognostic model from LIPI called intrahepatic immune prognostic index (IIPI) for ICC. A retrospectively study was conducted at Liver Transplant Center of West China Hospital between January 2015 and January 2023. Hematological factors and clinical features of ICC patients were collected and analyzed. The area under curve (AUC) and optimal cuff-off of each single hematological factor was calculated. In this study, derived neurtrophil to lymphocyte ratio (dNLR), arbohydrate antigen199 (CA199) and carcinoembryonic antigen (CEA) have higher AUC values. LIPI was composed of dNLR and was further modified by combing CA199 and CEA, forming the IIPI. The IIPI consists of four grades which are None, Light, Moderate and Severe. Compared to other prognostic factors, IIPI exhibited better ability to predict overall survival. The multivariate analysis indicated that cirrhosis, differentiation, hilar invasion and IIPI were independent prognostic factors for ICC patients. An IIPI-based nomogram was also established and could predict the overall survival. In addition, the subgroup analyses based on clinical prognostic factors showed that the IIPI exhibited excellent prognostic influence. IIPI model is suitable for predicting the prognosis of postoperative ICC patients. Further research is needed to explore the relationship between postoperative recurrence and metastasis of ICC patients and IIPI.https://doi.org/10.1038/s41598-023-45056-9 |
| spellingShingle | Yinghao Lv Hu Liu Penghui He Sinan Xie Xiuchun Yin Yunshi Cai Hong Wu A novel model for predicting the prognosis of postoperative intrahepatic cholangiocarcinoma patients Scientific Reports |
| title | A novel model for predicting the prognosis of postoperative intrahepatic cholangiocarcinoma patients |
| title_full | A novel model for predicting the prognosis of postoperative intrahepatic cholangiocarcinoma patients |
| title_fullStr | A novel model for predicting the prognosis of postoperative intrahepatic cholangiocarcinoma patients |
| title_full_unstemmed | A novel model for predicting the prognosis of postoperative intrahepatic cholangiocarcinoma patients |
| title_short | A novel model for predicting the prognosis of postoperative intrahepatic cholangiocarcinoma patients |
| title_sort | novel model for predicting the prognosis of postoperative intrahepatic cholangiocarcinoma patients |
| url | https://doi.org/10.1038/s41598-023-45056-9 |
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