Chemically Defined, High-Density Insect Cell-Based Expression System for Scalable AAV Vector Production

Chemically Defined, High-Density Insect Cell-Based Expression System for Scalable AAV Vector Production

The recombinant adeno-associated virus (AAV) vector is one of the most utilized viral vectors in gene therapy due to its robust, long-term in vivo transgene expression and low toxicity. One major hurdle for clinical AAV applications is large-scale manufacturing. In this regard, the baculovirus-based...

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Bibliographic Details
Main Authors: James H. Kurasawa, Andrew Park, Carrie R. Sowers, Rebecca A. Halpin, Andrey Tovchigrechko, Claire L. Dobson, Albert E. Schmelzer, Changshou Gao, Susan D. Wilson, Yasuhiro Ikeda
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
baculovirus
insect cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120302035

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