Comprehensive Immunological Study of Persons Vaccinated with Live Plague Vaccine Living on the Territory of the Pre-Caspian Sand Foci of the Plague in the Republic of Kalmykia
Relevance. In 2005 International Health Regulations, the plague, is on the list of dangerous infectious diseases that can cause emergency situations of interstate importance. Even single cases of human plague are considered as the basis for carrying out preventive measures. The paper presents the re...
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2018-06-01
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| Series: | Эпидемиология и вакцинопрофилактика |
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| Online Access: | https://www.epidemvac.ru/jour/article/view/518 |
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| author | S. A. Bugorkova T. N. Shchukovskaya N. I. Mikishis S. N. Klyueva O. M. Kudryavtseva A. L. Kravtsov A. Yu. Goncharova V. A. Kozhevnikov D. N. Sandzhiev S. V. Konusheva S. P. Savchenko E. S. Bembeeva S. A. Shcherbakova V. V. Kutyrev |
| author_facet | S. A. Bugorkova T. N. Shchukovskaya N. I. Mikishis S. N. Klyueva O. M. Kudryavtseva A. L. Kravtsov A. Yu. Goncharova V. A. Kozhevnikov D. N. Sandzhiev S. V. Konusheva S. P. Savchenko E. S. Bembeeva S. A. Shcherbakova V. V. Kutyrev |
| author_sort | S. A. Bugorkova |
| collection | DOAJ |
| description | Relevance. In 2005 International Health Regulations, the plague, is on the list of dangerous infectious diseases that can cause emergency situations of interstate importance. Even single cases of human plague are considered as the basis for carrying out preventive measures. The paper presents the results of immunological monitoring conducted on the territory of the Republic of Kalmykia in order to assess the immunological efficacy and safety of the plague live vaccine The paper presents the results of immunological monitoring in the territory of the Kalmyk Republic over the individuals vaccinated against plague due to epidemiological reasons. Materials and methods. Studies of immunological efficacy of live plague vaccine were conducted alongside stepwise assessment of cellular and humoral components of innate and adaptive immunity in persons revaccinated against plague, using a complex of advanced informative tests. Results and conclusions. It is established that before the second revaccination all the surveyed persons retained expressed immune response by the mixed or cellular type, characterized by high level of spontaneous and induced production of Th1-associated cytokines. Activation of Th1 immune reaction was registered one month after the scheduled revaccination; immune response change-over from Th1 to Th2 type – after 6 months of observation, and retention of adaptive immunity by mixed type at the moderate level – in a year. Specific humoral immunity developed in 85% of the surveyed persons, but throughout the whole investigation the dynamics of antibody titers to plague microbe F1 individualized and did not coincide with cellular immunity indicators. Performed complex study has confirmed the relative safety of the live plague vaccine. |
| first_indexed | 2024-04-10T02:50:42Z |
| format | Article |
| id | doaj.art-18e799502b3e442ca61664f4e5c3919d |
| institution | Directory Open Access Journal |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| last_indexed | 2024-04-10T02:50:42Z |
| publishDate | 2018-06-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj.art-18e799502b3e442ca61664f4e5c3919d2023-03-13T07:43:15ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942018-06-01173385010.31631/2073-3046-2018-17-3-38-50438Comprehensive Immunological Study of Persons Vaccinated with Live Plague Vaccine Living on the Territory of the Pre-Caspian Sand Foci of the Plague in the Republic of KalmykiaS. A. Bugorkova0T. N. Shchukovskaya1N. I. Mikishis2S. N. Klyueva3O. M. Kudryavtseva4A. L. Kravtsov5A. Yu. Goncharova6V. A. Kozhevnikov7D. N. Sandzhiev8S. V. Konusheva9S. P. Savchenko10E. S. Bembeeva11S. A. Shcherbakova12V. V. Kutyrev13ФКУЗ «Российский научно-исследовательский противочумный институт «Микроб» Роспотребнадзора, СаратовФКУЗ «Российский научно-исследовательский противочумный институт «Микроб» Роспотребнадзора, СаратовФКУЗ «Российский научно-исследовательский противочумный институт «Микроб» Роспотребнадзора, СаратовФКУЗ «Российский научно-исследовательский противочумный институт «Микроб» Роспотребнадзора, СаратовФКУЗ «Российский научно-исследовательский противочумный институт «Микроб» Роспотребнадзора, СаратовФКУЗ «Российский научно-исследовательский противочумный институт «Микроб» Роспотребнадзора, СаратовФКУЗ «Российский научно-исследовательский противочумный институт «Микроб» Роспотребнадзора, СаратовФКУЗ «Российский научно-исследовательский противочумный институт «Микроб» Роспотребнадзора, СаратовУправление Ропотребнадзора по Республике Калмыкия, ЭлистаУправление Ропотребнадзора по Республике Калмыкия, ЭлистаУправление Ропотребнадзора по Республике Калмыкия, ЭлистаФБУЗ «Центр гигиены и эпидемиологии в Республике Калмыкия», ЭлистаФКУЗ «Российский научно-исследовательский противочумный институт «Микроб» Роспотребнадзора, СаратовФКУЗ «Российский научно-исследовательский противочумный институт «Микроб» Роспотребнадзора, СаратовRelevance. In 2005 International Health Regulations, the plague, is on the list of dangerous infectious diseases that can cause emergency situations of interstate importance. Even single cases of human plague are considered as the basis for carrying out preventive measures. The paper presents the results of immunological monitoring conducted on the territory of the Republic of Kalmykia in order to assess the immunological efficacy and safety of the plague live vaccine The paper presents the results of immunological monitoring in the territory of the Kalmyk Republic over the individuals vaccinated against plague due to epidemiological reasons. Materials and methods. Studies of immunological efficacy of live plague vaccine were conducted alongside stepwise assessment of cellular and humoral components of innate and adaptive immunity in persons revaccinated against plague, using a complex of advanced informative tests. Results and conclusions. It is established that before the second revaccination all the surveyed persons retained expressed immune response by the mixed or cellular type, characterized by high level of spontaneous and induced production of Th1-associated cytokines. Activation of Th1 immune reaction was registered one month after the scheduled revaccination; immune response change-over from Th1 to Th2 type – after 6 months of observation, and retention of adaptive immunity by mixed type at the moderate level – in a year. Specific humoral immunity developed in 85% of the surveyed persons, but throughout the whole investigation the dynamics of antibody titers to plague microbe F1 individualized and did not coincide with cellular immunity indicators. Performed complex study has confirmed the relative safety of the live plague vaccine.https://www.epidemvac.ru/jour/article/view/518иммунологический мониторингживая чумная вакцинаиммунологическая эффективность |
| spellingShingle | S. A. Bugorkova T. N. Shchukovskaya N. I. Mikishis S. N. Klyueva O. M. Kudryavtseva A. L. Kravtsov A. Yu. Goncharova V. A. Kozhevnikov D. N. Sandzhiev S. V. Konusheva S. P. Savchenko E. S. Bembeeva S. A. Shcherbakova V. V. Kutyrev Comprehensive Immunological Study of Persons Vaccinated with Live Plague Vaccine Living on the Territory of the Pre-Caspian Sand Foci of the Plague in the Republic of Kalmykia Эпидемиология и вакцинопрофилактика иммунологический мониторинг живая чумная вакцина иммунологическая эффективность |
| title | Comprehensive Immunological Study of Persons Vaccinated with Live Plague Vaccine Living on the Territory of the Pre-Caspian Sand Foci of the Plague in the Republic of Kalmykia |
| title_full | Comprehensive Immunological Study of Persons Vaccinated with Live Plague Vaccine Living on the Territory of the Pre-Caspian Sand Foci of the Plague in the Republic of Kalmykia |
| title_fullStr | Comprehensive Immunological Study of Persons Vaccinated with Live Plague Vaccine Living on the Territory of the Pre-Caspian Sand Foci of the Plague in the Republic of Kalmykia |
| title_full_unstemmed | Comprehensive Immunological Study of Persons Vaccinated with Live Plague Vaccine Living on the Territory of the Pre-Caspian Sand Foci of the Plague in the Republic of Kalmykia |
| title_short | Comprehensive Immunological Study of Persons Vaccinated with Live Plague Vaccine Living on the Territory of the Pre-Caspian Sand Foci of the Plague in the Republic of Kalmykia |
| title_sort | comprehensive immunological study of persons vaccinated with live plague vaccine living on the territory of the pre caspian sand foci of the plague in the republic of kalmykia |
| topic | иммунологический мониторинг живая чумная вакцина иммунологическая эффективность |
| url | https://www.epidemvac.ru/jour/article/view/518 |
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