NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model

NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model

Background/Aims: Type 1 diabetes (T1D) is characterized by absolute insulin deficiency due to destruction of pancreatic β-cells by cytokines (e.g., interleukin-1β; IL-1β) released by invading immune cells. The mechanisms by which these cytokines induce β-cell dysfunction remain poorly understood. Re...

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Bibliographic Details
Main Authors: Rajakrishnan Veluthakal, Vaibhav Sidarala, Anjaneyulu Kowluru
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Nox2
Rac1
NOD mice
Pancreatic islet
ER stress
Diabetes
Online Access:http://prod.karger.com/Article/FullText/445666

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