A review of the “metallome” within neurons and glia, as revealed by elemental mapping of brain tissue
It is now well established that transition metals, such as Iron (Fe), Copper (Cu), and Zinc (Zn) are necessary for healthy brain function. Although Fe, Cu, and Zn are essential to the brain, imbalances in the amount, distribution, or chemical form (“metallome”) of these metals is linked to the patho...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | BBA Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667160321000375 |
| _version_ | 1818978500263018496 |
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| author | Gaewyn Ellison Ashley L. Hollings Mark J. Hackett |
| author_facet | Gaewyn Ellison Ashley L. Hollings Mark J. Hackett |
| author_sort | Gaewyn Ellison |
| collection | DOAJ |
| description | It is now well established that transition metals, such as Iron (Fe), Copper (Cu), and Zinc (Zn) are necessary for healthy brain function. Although Fe, Cu, and Zn are essential to the brain, imbalances in the amount, distribution, or chemical form (“metallome”) of these metals is linked to the pathology of numerous brain diseases or disorders. Despite the known importance of metal ions for both brain health and disease, the metallome that exists within specific types of brain cells is yet to be fully characterised. The aim of this mini-review is to present an overview of the current knowledge of the metallome found within specific brain cells (oligodendrocytes, astrocytes, microglia, and neurons), as revealed by direct elemental mapping techniques. It is hoped this review will foster continued research using direct elemental mapping techniques to fully characterise the brain cell metallome. |
| first_indexed | 2024-12-20T16:44:37Z |
| format | Article |
| id | doaj.art-18eb3ba2f7f644d2ad585b64ffa89fdf |
| institution | Directory Open Access Journal |
| issn | 2667-1603 |
| language | English |
| last_indexed | 2024-12-20T16:44:37Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | BBA Advances |
| spelling | doaj.art-18eb3ba2f7f644d2ad585b64ffa89fdf2022-12-21T19:32:57ZengElsevierBBA Advances2667-16032022-01-012100038A review of the “metallome” within neurons and glia, as revealed by elemental mapping of brain tissueGaewyn Ellison0Ashley L. Hollings1Mark J. Hackett2School of Molecular and Life Sciences, Curtin University, Perth, WA 6845, Australia; Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6102, AustraliaSchool of Molecular and Life Sciences, Curtin University, Perth, WA 6845, Australia; Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6102, AustraliaSchool of Molecular and Life Sciences, Curtin University, Perth, WA 6845, Australia; Curtin Health Innovation Research Institute, Curtin University, Perth, WA 6102, Australia; Corresponding author.It is now well established that transition metals, such as Iron (Fe), Copper (Cu), and Zinc (Zn) are necessary for healthy brain function. Although Fe, Cu, and Zn are essential to the brain, imbalances in the amount, distribution, or chemical form (“metallome”) of these metals is linked to the pathology of numerous brain diseases or disorders. Despite the known importance of metal ions for both brain health and disease, the metallome that exists within specific types of brain cells is yet to be fully characterised. The aim of this mini-review is to present an overview of the current knowledge of the metallome found within specific brain cells (oligodendrocytes, astrocytes, microglia, and neurons), as revealed by direct elemental mapping techniques. It is hoped this review will foster continued research using direct elemental mapping techniques to fully characterise the brain cell metallome.http://www.sciencedirect.com/science/article/pii/S2667160321000375MicroscopyMetalsNeuroscienceHippocampusNeurodegeneration |
| spellingShingle | Gaewyn Ellison Ashley L. Hollings Mark J. Hackett A review of the “metallome” within neurons and glia, as revealed by elemental mapping of brain tissue BBA Advances Microscopy Metals Neuroscience Hippocampus Neurodegeneration |
| title | A review of the “metallome” within neurons and glia, as revealed by elemental mapping of brain tissue |
| title_full | A review of the “metallome” within neurons and glia, as revealed by elemental mapping of brain tissue |
| title_fullStr | A review of the “metallome” within neurons and glia, as revealed by elemental mapping of brain tissue |
| title_full_unstemmed | A review of the “metallome” within neurons and glia, as revealed by elemental mapping of brain tissue |
| title_short | A review of the “metallome” within neurons and glia, as revealed by elemental mapping of brain tissue |
| title_sort | review of the metallome within neurons and glia as revealed by elemental mapping of brain tissue |
| topic | Microscopy Metals Neuroscience Hippocampus Neurodegeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2667160321000375 |
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