Physiological Shear Stress Enhances Differentiation, Mucus-Formation and Structural 3D Organization of Intestinal Epithelial Cells In Vitro

Physiological Shear Stress Enhances Differentiation, Mucus-Formation and Structural 3D Organization of Intestinal Epithelial Cells In Vitro

Gastrointestinal (GI) mucus plays a pivotal role in the tissue homoeostasis and functionality of the gut. However, due to the shortage of affordable, realistic in vitro GI models with a physiologically relevant mucus layer, studies with deeper insights into structural and compositional changes upon...

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Bibliographic Details
Main Authors: Marcus Lindner, Anna Laporte, Stephan Block, Laura Elomaa, Marie Weinhart
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
3D-printed insert chamber
bioreactor
cell-based mucus model
cellular self-organization
CFD simulation
goblet cell differentiation
Online Access:https://www.mdpi.com/2073-4409/10/8/2062

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