Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1.

Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1.

Epstein-Barr virus (EBV) has developed effective strategies to evade host innate immune responses. Here we reported on mitigation of type I interferon (IFN) production by EBV deubiquitinase (DUB) BPLF1 through cGAS-STING and RIG-I-MAVS pathways. The two naturally occurring forms of BPLF1 exerted pot...

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Bibliographic Details
Main Authors: Wai-Yin Lui, Aradhana Bharti, Nok-Hei Mickey Wong, Sonia Jangra, Michael G Botelho, Kit-San Yuen, Dong-Yan Jin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011186

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