Growth Parameters and Vitamin D status in Children with Thalassemia Major in Upper Egypt
Aim: the aim of this study is to assess the growth parameters, vitamin D, calcium, and phosphorous status in children with thalassemia major receiving packed red cells transfusion with chelation therapy. Patients and Methods: In a case control study, 100 patients with beta thalassemia major (aged f...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2013-12-01
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| Series: | International Journal of Hematology-Oncology and Stem Cell Research |
| Subjects: | |
| Online Access: | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/442 |
| _version_ | 1797759911295188992 |
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| author | Fahim M Fahim Khaled Saad Eman A Askar Eman Nasr Eldin Ahmed F Thabet |
| author_facet | Fahim M Fahim Khaled Saad Eman A Askar Eman Nasr Eldin Ahmed F Thabet |
| author_sort | Fahim M Fahim |
| collection | DOAJ |
| description | Aim: the aim of this study is to assess the growth parameters, vitamin D, calcium, and phosphorous status in children with thalassemia major receiving packed red cells transfusion with chelation therapy.
Patients and Methods: In a case control study, 100 patients with beta thalassemia major (aged from 4 to 15 years) were compared with 100 sex- and age-matched children serves as a control group. Anthropometric measurement, Serum level of calcium, phosphorus and vitamin D (25 hydroxycholecalciferol) were estimated for all patients & controls.
Results: 49% of our patients had short stature. 47% were underweight. BMI of 43 (43%) patients were low. The mean total serum calcium (6.6±1.2 mg/dl) and 25-hydroxycholecalciferol (25-OH Vit D) (10.4±4.6 mcg/dl) levels were significantly lower in our patients than in controls (10.2±1.06 mg/dl and 40.2±12.3 mcg/dl, respectively); each P< 0.001.
Conclusion: Children with beta thalassemia major have delayed growth and metabolic abnormalities that signify the importance of therapeutic interventions. The presence of these abnormalities may be due to iron overload and poor nutritional support. |
| first_indexed | 2024-03-12T18:51:16Z |
| format | Article |
| id | doaj.art-18ef9a375e304f9e8a23af62f9157363 |
| institution | Directory Open Access Journal |
| issn | 2008-2207 |
| language | English |
| last_indexed | 2024-03-12T18:51:16Z |
| publishDate | 2013-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | International Journal of Hematology-Oncology and Stem Cell Research |
| spelling | doaj.art-18ef9a375e304f9e8a23af62f91573632023-08-02T07:12:50ZengTehran University of Medical SciencesInternational Journal of Hematology-Oncology and Stem Cell Research2008-22072013-12-0174428Growth Parameters and Vitamin D status in Children with Thalassemia Major in Upper EgyptFahim M Fahim0Khaled Saad1Eman A Askar2Eman Nasr Eldin3Ahmed F Thabet4Department of Pediatrics, Assiut University, Assiut 71516, Egypt.Department of Pediatrics, Assiut University, Assiut 71516, Egypt.Department of Pediatrics, Assiut University, Assiut 71516, Egypt.Department of clinical pathology, Assiut University, Assiut 71516, Egypt.Department of internal medicine, Assiut University, Assiut 71516, Egypt.Aim: the aim of this study is to assess the growth parameters, vitamin D, calcium, and phosphorous status in children with thalassemia major receiving packed red cells transfusion with chelation therapy. Patients and Methods: In a case control study, 100 patients with beta thalassemia major (aged from 4 to 15 years) were compared with 100 sex- and age-matched children serves as a control group. Anthropometric measurement, Serum level of calcium, phosphorus and vitamin D (25 hydroxycholecalciferol) were estimated for all patients & controls. Results: 49% of our patients had short stature. 47% were underweight. BMI of 43 (43%) patients were low. The mean total serum calcium (6.6±1.2 mg/dl) and 25-hydroxycholecalciferol (25-OH Vit D) (10.4±4.6 mcg/dl) levels were significantly lower in our patients than in controls (10.2±1.06 mg/dl and 40.2±12.3 mcg/dl, respectively); each P< 0.001. Conclusion: Children with beta thalassemia major have delayed growth and metabolic abnormalities that signify the importance of therapeutic interventions. The presence of these abnormalities may be due to iron overload and poor nutritional support.https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/442CalciumGrowthThalassemia majorVitamin D |
| spellingShingle | Fahim M Fahim Khaled Saad Eman A Askar Eman Nasr Eldin Ahmed F Thabet Growth Parameters and Vitamin D status in Children with Thalassemia Major in Upper Egypt International Journal of Hematology-Oncology and Stem Cell Research Calcium Growth Thalassemia major Vitamin D |
| title | Growth Parameters and Vitamin D status in Children with Thalassemia Major in Upper Egypt |
| title_full | Growth Parameters and Vitamin D status in Children with Thalassemia Major in Upper Egypt |
| title_fullStr | Growth Parameters and Vitamin D status in Children with Thalassemia Major in Upper Egypt |
| title_full_unstemmed | Growth Parameters and Vitamin D status in Children with Thalassemia Major in Upper Egypt |
| title_short | Growth Parameters and Vitamin D status in Children with Thalassemia Major in Upper Egypt |
| title_sort | growth parameters and vitamin d status in children with thalassemia major in upper egypt |
| topic | Calcium Growth Thalassemia major Vitamin D |
| url | https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/442 |
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