Inhibitory Effects against Alpha-Amylase of an Enriched Polyphenol Extract from Pericarp of Mangosteen (<i>Garcinia mangostana</i>)
The pericarp of mangosteen, a by-product of the mangosteen, is rich in polyphenols. In this study, an efficient and environmentally friendly method for preparative enrichment of polyphenols from mangosteen pericarp (MPPs) was developed, and the inhibitory effects on starch digestion were also evalua...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-03-01
|
| Series: | Foods |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2304-8158/11/7/1001 |
| _version_ | 1797439256888606720 |
|---|---|
| author | Xiaofang Li Haoze Chen Yan Jia Jinming Peng Chunmei Li |
| author_facet | Xiaofang Li Haoze Chen Yan Jia Jinming Peng Chunmei Li |
| author_sort | Xiaofang Li |
| collection | DOAJ |
| description | The pericarp of mangosteen, a by-product of the mangosteen, is rich in polyphenols. In this study, an efficient and environmentally friendly method for preparative enrichment of polyphenols from mangosteen pericarp (MPPs) was developed, and the inhibitory effects on starch digestion were also evaluated. It was found that the optimal extract method of MPPs was at a solid to solvent ratio of 1:50 g/mL, pH of 2, and at 80 °C for 2 h. The IC<sub>50</sub> of MPPs for α-amylase was 0.28 mg/mL. Based on the fluorescence quenching results, we presumed that MPPs could alter the natural structure of α-amylase, resulting in inhibitory activity on α-amylase. In addition, MPPs significantly reduced the blood glucose peak and AUC of glucose responses in rats after ingestion of the starch solution. Taken together, MPPs may have the potential as a functional supplement for blood glucose control and diabetes prevention. |
| first_indexed | 2024-03-09T11:50:08Z |
| format | Article |
| id | doaj.art-18f063b06f1741dea450cafcac9ff142 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T11:50:08Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-18f063b06f1741dea450cafcac9ff1422023-11-30T23:15:37ZengMDPI AGFoods2304-81582022-03-01117100110.3390/foods11071001Inhibitory Effects against Alpha-Amylase of an Enriched Polyphenol Extract from Pericarp of Mangosteen (<i>Garcinia mangostana</i>)Xiaofang Li0Haoze Chen1Yan Jia2Jinming Peng3Chunmei Li4College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, ChinaCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, ChinaBeijing Key Lab of Plant Resource Research and Development, School of Science, Beijing Technology and Business University, Beijing 100048, ChinaCollege of Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, ChinaCollege of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, ChinaThe pericarp of mangosteen, a by-product of the mangosteen, is rich in polyphenols. In this study, an efficient and environmentally friendly method for preparative enrichment of polyphenols from mangosteen pericarp (MPPs) was developed, and the inhibitory effects on starch digestion were also evaluated. It was found that the optimal extract method of MPPs was at a solid to solvent ratio of 1:50 g/mL, pH of 2, and at 80 °C for 2 h. The IC<sub>50</sub> of MPPs for α-amylase was 0.28 mg/mL. Based on the fluorescence quenching results, we presumed that MPPs could alter the natural structure of α-amylase, resulting in inhibitory activity on α-amylase. In addition, MPPs significantly reduced the blood glucose peak and AUC of glucose responses in rats after ingestion of the starch solution. Taken together, MPPs may have the potential as a functional supplement for blood glucose control and diabetes prevention.https://www.mdpi.com/2304-8158/11/7/1001Mangosteen (<i>Garcinia mangostana</i>)polyphenolα-amylase inhibitionfluorescence quenchingpostprandial blood glucose level |
| spellingShingle | Xiaofang Li Haoze Chen Yan Jia Jinming Peng Chunmei Li Inhibitory Effects against Alpha-Amylase of an Enriched Polyphenol Extract from Pericarp of Mangosteen (<i>Garcinia mangostana</i>) Foods Mangosteen (<i>Garcinia mangostana</i>) polyphenol α-amylase inhibition fluorescence quenching postprandial blood glucose level |
| title | Inhibitory Effects against Alpha-Amylase of an Enriched Polyphenol Extract from Pericarp of Mangosteen (<i>Garcinia mangostana</i>) |
| title_full | Inhibitory Effects against Alpha-Amylase of an Enriched Polyphenol Extract from Pericarp of Mangosteen (<i>Garcinia mangostana</i>) |
| title_fullStr | Inhibitory Effects against Alpha-Amylase of an Enriched Polyphenol Extract from Pericarp of Mangosteen (<i>Garcinia mangostana</i>) |
| title_full_unstemmed | Inhibitory Effects against Alpha-Amylase of an Enriched Polyphenol Extract from Pericarp of Mangosteen (<i>Garcinia mangostana</i>) |
| title_short | Inhibitory Effects against Alpha-Amylase of an Enriched Polyphenol Extract from Pericarp of Mangosteen (<i>Garcinia mangostana</i>) |
| title_sort | inhibitory effects against alpha amylase of an enriched polyphenol extract from pericarp of mangosteen i garcinia mangostana i |
| topic | Mangosteen (<i>Garcinia mangostana</i>) polyphenol α-amylase inhibition fluorescence quenching postprandial blood glucose level |
| url | https://www.mdpi.com/2304-8158/11/7/1001 |
| work_keys_str_mv | AT xiaofangli inhibitoryeffectsagainstalphaamylaseofanenrichedpolyphenolextractfrompericarpofmangosteenigarciniamangostanai AT haozechen inhibitoryeffectsagainstalphaamylaseofanenrichedpolyphenolextractfrompericarpofmangosteenigarciniamangostanai AT yanjia inhibitoryeffectsagainstalphaamylaseofanenrichedpolyphenolextractfrompericarpofmangosteenigarciniamangostanai AT jinmingpeng inhibitoryeffectsagainstalphaamylaseofanenrichedpolyphenolextractfrompericarpofmangosteenigarciniamangostanai AT chunmeili inhibitoryeffectsagainstalphaamylaseofanenrichedpolyphenolextractfrompericarpofmangosteenigarciniamangostanai |