Subclinical Atherosclerosis Measure by Carotid Ultrasound and Inflammatory Activity in Patients with Rheumatoid Arthritis and Spondylarthritis
Objective: To compare the effect of inflammation on subclinical atherosclerosis using carotid ultrasound in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA). Methods: Cross-sectional study including 347 participants (148 RA, 159 SpA, and 40 controls). We measured the carotid intim...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/3/662 |
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| author | Marta Rojas-Giménez Clementina López-Medina María Lourdes Ladehesa-Pineda María Ángeles Puche-Larrubia Ignacio Gómez-García Jerusalem Calvo-Gutiérrez Pedro Seguí-Azpilcueta María del Carmen Ábalos-Aguilera Desirée Ruíz-Vilchez Alejandro Escudero-Contreras Eduardo Collantes-Estévez |
| author_facet | Marta Rojas-Giménez Clementina López-Medina María Lourdes Ladehesa-Pineda María Ángeles Puche-Larrubia Ignacio Gómez-García Jerusalem Calvo-Gutiérrez Pedro Seguí-Azpilcueta María del Carmen Ábalos-Aguilera Desirée Ruíz-Vilchez Alejandro Escudero-Contreras Eduardo Collantes-Estévez |
| author_sort | Marta Rojas-Giménez |
| collection | DOAJ |
| description | Objective: To compare the effect of inflammation on subclinical atherosclerosis using carotid ultrasound in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA). Methods: Cross-sectional study including 347 participants (148 RA, 159 SpA, and 40 controls). We measured the carotid intima media thickness (cIMT) and detection of atheromatous plaques using carotid ultrasound. We recorded disease activity (DAS28-CRP/ASDAS-CRP) and traditional cardiovascular risk factors. We performed descriptive, bivariate, and linear multivariate analyses (dependent variable: cIMT) to evaluate the influence of diagnosis on cIMT in all patients. Two additional multivariate analyses were performed by stratifying patients according to their inflammatory activity. Results: cIMT correlated with the mean CRP during the previous 5 years in RA, but not with CRP at the cut-off date. We did not find such differences in patients with SpA. The first multivariate model revealed that increased cIMT was more common in patients with RA than in those with SpA (β coefficient, 0.045; 95% confidence interval (95% CI), 0.0002–0.09; <i>p</i> = 0.048) after adjusting for age, sex, disease course, and differential cardiovascular risk factors (arterial hypertension, smoking, statins, and corticosteroids). The second model revealed no differences in cIMT between the 2 groups of patients classified as remission–low activity (β coefficient, 0.020; 95% CI, −0.03 to 0.080; <i>p</i> = 0.500). However, when only patients with moderate–high disease activity were analysed, the cIMT was 0.112 mm greater in those with RA (95% CI, 0.013–0.212; <i>p</i> = 0.026) than in those with SpA after adjusting for the same variables. Conclusions: Subclinical atherosclerosis measured by carotid ultrasound in patients with RA and SpA is comparable when the disease is well controlled. However, when patients have moderate–high disease activity, cIMT is greater in patients with RA than in those with SpA after adjusting for age, sex, disease course, and cardiovascular risk factors. Our results point to greater involvement of disease activity in subclinical atherosclerosis in patients with RA than in those with SpA. |
| first_indexed | 2024-03-09T23:40:34Z |
| format | Article |
| id | doaj.art-18f081e065e94e3f8aa2461c783e0a15 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:40:34Z |
| publishDate | 2022-01-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-18f081e065e94e3f8aa2461c783e0a152023-11-23T16:52:02ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111366210.3390/jcm11030662Subclinical Atherosclerosis Measure by Carotid Ultrasound and Inflammatory Activity in Patients with Rheumatoid Arthritis and SpondylarthritisMarta Rojas-Giménez0Clementina López-Medina1María Lourdes Ladehesa-Pineda2María Ángeles Puche-Larrubia3Ignacio Gómez-García4Jerusalem Calvo-Gutiérrez5Pedro Seguí-Azpilcueta6María del Carmen Ábalos-Aguilera7Desirée Ruíz-Vilchez8Alejandro Escudero-Contreras9Eduardo Collantes-Estévez10Rheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, SpainRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, SpainRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, SpainRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, SpainRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, SpainRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, SpainRadiology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), 14004 Cordoba, SpainRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, SpainRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, SpainRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, SpainRheumatology Department, Reina Sofia University Hospital, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Córdoba (UCO), 14004 Cordoba, SpainObjective: To compare the effect of inflammation on subclinical atherosclerosis using carotid ultrasound in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA). Methods: Cross-sectional study including 347 participants (148 RA, 159 SpA, and 40 controls). We measured the carotid intima media thickness (cIMT) and detection of atheromatous plaques using carotid ultrasound. We recorded disease activity (DAS28-CRP/ASDAS-CRP) and traditional cardiovascular risk factors. We performed descriptive, bivariate, and linear multivariate analyses (dependent variable: cIMT) to evaluate the influence of diagnosis on cIMT in all patients. Two additional multivariate analyses were performed by stratifying patients according to their inflammatory activity. Results: cIMT correlated with the mean CRP during the previous 5 years in RA, but not with CRP at the cut-off date. We did not find such differences in patients with SpA. The first multivariate model revealed that increased cIMT was more common in patients with RA than in those with SpA (β coefficient, 0.045; 95% confidence interval (95% CI), 0.0002–0.09; <i>p</i> = 0.048) after adjusting for age, sex, disease course, and differential cardiovascular risk factors (arterial hypertension, smoking, statins, and corticosteroids). The second model revealed no differences in cIMT between the 2 groups of patients classified as remission–low activity (β coefficient, 0.020; 95% CI, −0.03 to 0.080; <i>p</i> = 0.500). However, when only patients with moderate–high disease activity were analysed, the cIMT was 0.112 mm greater in those with RA (95% CI, 0.013–0.212; <i>p</i> = 0.026) than in those with SpA after adjusting for the same variables. Conclusions: Subclinical atherosclerosis measured by carotid ultrasound in patients with RA and SpA is comparable when the disease is well controlled. However, when patients have moderate–high disease activity, cIMT is greater in patients with RA than in those with SpA after adjusting for age, sex, disease course, and cardiovascular risk factors. Our results point to greater involvement of disease activity in subclinical atherosclerosis in patients with RA than in those with SpA.https://www.mdpi.com/2077-0383/11/3/662rheumatoid arthritisspondyloarthritissubclinical atherosclerosiscardiovascular riskinflammatory activity |
| spellingShingle | Marta Rojas-Giménez Clementina López-Medina María Lourdes Ladehesa-Pineda María Ángeles Puche-Larrubia Ignacio Gómez-García Jerusalem Calvo-Gutiérrez Pedro Seguí-Azpilcueta María del Carmen Ábalos-Aguilera Desirée Ruíz-Vilchez Alejandro Escudero-Contreras Eduardo Collantes-Estévez Subclinical Atherosclerosis Measure by Carotid Ultrasound and Inflammatory Activity in Patients with Rheumatoid Arthritis and Spondylarthritis Journal of Clinical Medicine rheumatoid arthritis spondyloarthritis subclinical atherosclerosis cardiovascular risk inflammatory activity |
| title | Subclinical Atherosclerosis Measure by Carotid Ultrasound and Inflammatory Activity in Patients with Rheumatoid Arthritis and Spondylarthritis |
| title_full | Subclinical Atherosclerosis Measure by Carotid Ultrasound and Inflammatory Activity in Patients with Rheumatoid Arthritis and Spondylarthritis |
| title_fullStr | Subclinical Atherosclerosis Measure by Carotid Ultrasound and Inflammatory Activity in Patients with Rheumatoid Arthritis and Spondylarthritis |
| title_full_unstemmed | Subclinical Atherosclerosis Measure by Carotid Ultrasound and Inflammatory Activity in Patients with Rheumatoid Arthritis and Spondylarthritis |
| title_short | Subclinical Atherosclerosis Measure by Carotid Ultrasound and Inflammatory Activity in Patients with Rheumatoid Arthritis and Spondylarthritis |
| title_sort | subclinical atherosclerosis measure by carotid ultrasound and inflammatory activity in patients with rheumatoid arthritis and spondylarthritis |
| topic | rheumatoid arthritis spondyloarthritis subclinical atherosclerosis cardiovascular risk inflammatory activity |
| url | https://www.mdpi.com/2077-0383/11/3/662 |
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