Cardiovascular effects of angiotensin A: A novel peptide of the renin–angiotensin system
Introduction: Angiotensin (Ang) A was first identified in human plasma and it differs from Ang II in Ala 1 instead of Asp 1 . Here, we hypothesized that the actions of this peptide might explain, at least partially, the limited effects of AT 1 R antagonists in certain cardiovascular diseases. Materi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2014-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320312474856 |
| _version_ | 1797281861046632448 |
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| author | Danielle CO Coutinho Giselle Foureaux Keyla DL Rodrigues Rodrigo LA Salles Patrícia L Moraes Tatiane M Murça Marilda LA De Maria Enéas RM Gomes Robson AS Santos Sílvia Guatimosim Anderson J Ferreira |
| author_facet | Danielle CO Coutinho Giselle Foureaux Keyla DL Rodrigues Rodrigo LA Salles Patrícia L Moraes Tatiane M Murça Marilda LA De Maria Enéas RM Gomes Robson AS Santos Sílvia Guatimosim Anderson J Ferreira |
| author_sort | Danielle CO Coutinho |
| collection | DOAJ |
| description | Introduction: Angiotensin (Ang) A was first identified in human plasma and it differs from Ang II in Ala 1 instead of Asp 1 . Here, we hypothesized that the actions of this peptide might explain, at least partially, the limited effects of AT 1 R antagonists in certain cardiovascular diseases. Materials and methods: The effects of Ang A and Ang II on blood pressure (BP) and heart function were compared. Importantly, participation of AT 1 R in these effects was evaluated. Furthermore, the effects of these two peptides on ischemia/reperfusion arrhythmias and involvement of calcium in these effects were investigated. Results: Administration of increasing doses of these peptides caused elevations in BP at comparable magnitude. AT 1 R blockade completely abolished these effects. The actions of these peptides in cardiac function were quite similar although the effects of Ang A were only partially blocked by losartan. Interestingly, Ang II elicited an increase in the duration of ischemia/reperfusion arrhythmias while Ang A had no effect on cardiac rhythm during reperfusion. In accordance, differently to Ang II, Ang A did not induce any significant effect on calcium transient during baseline and ischemic stress conditions. Conclusions: These data suggest that the existence of alternative peptides of the renin–angiotensin system (RAS) might contribute to the limited effects of angiotensin receptor blockers (ARBs) in certain pathophysiological circumstances. |
| first_indexed | 2024-03-07T17:03:33Z |
| format | Article |
| id | doaj.art-18f08b23f3bc4d5ca8258c4f6181fc2b |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:03:33Z |
| publishDate | 2014-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-18f08b23f3bc4d5ca8258c4f6181fc2b2024-03-03T02:50:33ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762014-12-011510.1177/1470320312474856Cardiovascular effects of angiotensin A: A novel peptide of the renin–angiotensin systemDanielle CO Coutinho0Giselle Foureaux1Keyla DL Rodrigues2Rodrigo LA Salles3Patrícia L Moraes4Tatiane M Murça5Marilda LA De Maria6Enéas RM Gomes7Robson AS Santos8Sílvia Guatimosim9Anderson J Ferreira10 Department of Morphology, Federal University of Minas Gerais, Brazil Department of Morphology, Federal University of Minas Gerais, Brazil Department of Morphology, Federal University of Minas Gerais, Brazil Department of Morphology, Federal University of Minas Gerais, Brazil Department of Morphology, Federal University of Minas Gerais, Brazil Department of Morphology, Federal University of Minas Gerais, Brazil Department of Morphology, Federal University of Minas Gerais, Brazil Department of Physiology and Biophysics, Federal University of Minas Gerais, Brazil Department of Physiology and Biophysics, Federal University of Minas Gerais, Brazil Department of Physiology and Biophysics, Federal University of Minas Gerais, Brazil Department of Morphology, Federal University of Minas Gerais, BrazilIntroduction: Angiotensin (Ang) A was first identified in human plasma and it differs from Ang II in Ala 1 instead of Asp 1 . Here, we hypothesized that the actions of this peptide might explain, at least partially, the limited effects of AT 1 R antagonists in certain cardiovascular diseases. Materials and methods: The effects of Ang A and Ang II on blood pressure (BP) and heart function were compared. Importantly, participation of AT 1 R in these effects was evaluated. Furthermore, the effects of these two peptides on ischemia/reperfusion arrhythmias and involvement of calcium in these effects were investigated. Results: Administration of increasing doses of these peptides caused elevations in BP at comparable magnitude. AT 1 R blockade completely abolished these effects. The actions of these peptides in cardiac function were quite similar although the effects of Ang A were only partially blocked by losartan. Interestingly, Ang II elicited an increase in the duration of ischemia/reperfusion arrhythmias while Ang A had no effect on cardiac rhythm during reperfusion. In accordance, differently to Ang II, Ang A did not induce any significant effect on calcium transient during baseline and ischemic stress conditions. Conclusions: These data suggest that the existence of alternative peptides of the renin–angiotensin system (RAS) might contribute to the limited effects of angiotensin receptor blockers (ARBs) in certain pathophysiological circumstances.https://doi.org/10.1177/1470320312474856 |
| spellingShingle | Danielle CO Coutinho Giselle Foureaux Keyla DL Rodrigues Rodrigo LA Salles Patrícia L Moraes Tatiane M Murça Marilda LA De Maria Enéas RM Gomes Robson AS Santos Sílvia Guatimosim Anderson J Ferreira Cardiovascular effects of angiotensin A: A novel peptide of the renin–angiotensin system Journal of the Renin-Angiotensin-Aldosterone System |
| title | Cardiovascular effects of angiotensin A: A novel peptide of the renin–angiotensin system |
| title_full | Cardiovascular effects of angiotensin A: A novel peptide of the renin–angiotensin system |
| title_fullStr | Cardiovascular effects of angiotensin A: A novel peptide of the renin–angiotensin system |
| title_full_unstemmed | Cardiovascular effects of angiotensin A: A novel peptide of the renin–angiotensin system |
| title_short | Cardiovascular effects of angiotensin A: A novel peptide of the renin–angiotensin system |
| title_sort | cardiovascular effects of angiotensin a a novel peptide of the renin angiotensin system |
| url | https://doi.org/10.1177/1470320312474856 |
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