Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites
Reiji Yoshimura,1,* Taro Kishi,2,* Nakao Iwata2 1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 8078555, Japan; 2Department of Psychiatry, Fujita Medical University, Toyoake Aichi 4701192, Japan*These authors contributed equally to this workCorresp...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-09-01
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| Series: | Neuropsychiatric Disease and Treatment |
| Subjects: | |
| Online Access: | https://www.dovepress.com/plasma-levels-of-il-6-in-patients-with-untreated-major-depressive-diso-peer-reviewed-article-NDT |
| _version_ | 1818682170238042112 |
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| author | Yoshimura R Kishi T Iwata N |
| author_facet | Yoshimura R Kishi T Iwata N |
| author_sort | Yoshimura R |
| collection | DOAJ |
| description | Reiji Yoshimura,1,* Taro Kishi,2,* Nakao Iwata2 1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 8078555, Japan; 2Department of Psychiatry, Fujita Medical University, Toyoake Aichi 4701192, Japan*These authors contributed equally to this workCorrespondence: Reiji YoshimuraDepartment of Psychiatry, University of Occupational and Environmental Health, Kitakyushu Fukuoka 8078555, JapanTell +81936917253Email yoshi621@med.uoeh-u.ac.jpObjective: IL-6 and catecholamines play roles in the pathophysiology of major depressive disorder (MDD).Aim: The present study investigated associations between plasma IL-6 and plasma catecholamine metabolites in patients with MDD.Participants and methods: A total of 148 patients (male/female 65/83, age 49.5±12.1 years) who met the criteria for MDD based on the Diagnostic and Statistical Manual of Mental Disorders IV and 40 participants as healthy controls (HC; male/female 23/17, age 44.0±10.5 years) were enrolled in the present study. Plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) were analyzed using high-performance liquid chromatography, and plasma IL-6 levels were measured using ELISA.Results: No correlations were observed among plasma IL-6 levels, MHPG levels, and HVA levels in patients with MDD. Plasma IL-6 levels in patients with MDD were significantly higher than in the HC. A positive correlation was found between plasma IL-6 levels and Hamilton Rating Scale for Depression-17 scores.Conclusion: No correlations existed between plasma IL-6 levels and plasma catecholamine metabolite levels in patients with MDD, and the severity of depressive state was related to plasma IL-6 levels in MDD.Keywords: IL-6, 3-methoxy-4-hydroxyphenylglycol, homovanillic acid, major depressive disorder, Hamilton Rating Scale for Depression |
| first_indexed | 2024-12-17T10:14:35Z |
| format | Article |
| id | doaj.art-18f4f185196d4ecbbb069589b685b569 |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-12-17T10:14:35Z |
| publishDate | 2019-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-18f4f185196d4ecbbb069589b685b5692022-12-21T21:52:57ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212019-09-01Volume 152655266148579Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolitesYoshimura RKishi TIwata NReiji Yoshimura,1,* Taro Kishi,2,* Nakao Iwata2 1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka 8078555, Japan; 2Department of Psychiatry, Fujita Medical University, Toyoake Aichi 4701192, Japan*These authors contributed equally to this workCorrespondence: Reiji YoshimuraDepartment of Psychiatry, University of Occupational and Environmental Health, Kitakyushu Fukuoka 8078555, JapanTell +81936917253Email yoshi621@med.uoeh-u.ac.jpObjective: IL-6 and catecholamines play roles in the pathophysiology of major depressive disorder (MDD).Aim: The present study investigated associations between plasma IL-6 and plasma catecholamine metabolites in patients with MDD.Participants and methods: A total of 148 patients (male/female 65/83, age 49.5±12.1 years) who met the criteria for MDD based on the Diagnostic and Statistical Manual of Mental Disorders IV and 40 participants as healthy controls (HC; male/female 23/17, age 44.0±10.5 years) were enrolled in the present study. Plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and homovanillic acid (HVA) were analyzed using high-performance liquid chromatography, and plasma IL-6 levels were measured using ELISA.Results: No correlations were observed among plasma IL-6 levels, MHPG levels, and HVA levels in patients with MDD. Plasma IL-6 levels in patients with MDD were significantly higher than in the HC. A positive correlation was found between plasma IL-6 levels and Hamilton Rating Scale for Depression-17 scores.Conclusion: No correlations existed between plasma IL-6 levels and plasma catecholamine metabolite levels in patients with MDD, and the severity of depressive state was related to plasma IL-6 levels in MDD.Keywords: IL-6, 3-methoxy-4-hydroxyphenylglycol, homovanillic acid, major depressive disorder, Hamilton Rating Scale for Depressionhttps://www.dovepress.com/plasma-levels-of-il-6-in-patients-with-untreated-major-depressive-diso-peer-reviewed-article-NDTInterleukin-63-methoxy-4-hydroxypheneylglycolhomovanillic acidmajor depressive disorderHamilton Rating Scale for Depression |
| spellingShingle | Yoshimura R Kishi T Iwata N Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites Neuropsychiatric Disease and Treatment Interleukin-6 3-methoxy-4-hydroxypheneylglycol homovanillic acid major depressive disorder Hamilton Rating Scale for Depression |
| title | Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites |
| title_full | Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites |
| title_fullStr | Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites |
| title_full_unstemmed | Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites |
| title_short | Plasma levels of IL-6 in patients with untreated major depressive disorder: comparison with catecholamine metabolites |
| title_sort | plasma levels of il 6 in patients with untreated major depressive disorder comparison with catecholamine metabolites |
| topic | Interleukin-6 3-methoxy-4-hydroxypheneylglycol homovanillic acid major depressive disorder Hamilton Rating Scale for Depression |
| url | https://www.dovepress.com/plasma-levels-of-il-6-in-patients-with-untreated-major-depressive-diso-peer-reviewed-article-NDT |
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