A multiscale approach to targeted docetaxel formulations: combination therapy, nanotechnology, electrospinning and 3D printing—a review
Abstract Background Cancer remains one of the leading causes of death worldwide. Docetaxel, first marketed as ‘Taxotere’, has been approved for use as a chemotherapeutic for management of gastric, breast, neck, head, non-small cell lung cancer and prostate cancer. Main body Taxotere, is a docetaxel...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-06-01
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| Series: | Bulletin of the National Research Centre |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s42269-022-00854-5 |
| _version_ | 1818202199835017216 |
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| author | Karamot O. Oyediran Margaret O. Ilomuanya Chukwuemeka P. Azubuike Layeni Nurudeen |
| author_facet | Karamot O. Oyediran Margaret O. Ilomuanya Chukwuemeka P. Azubuike Layeni Nurudeen |
| author_sort | Karamot O. Oyediran |
| collection | DOAJ |
| description | Abstract Background Cancer remains one of the leading causes of death worldwide. Docetaxel, first marketed as ‘Taxotere’, has been approved for use as a chemotherapeutic for management of gastric, breast, neck, head, non-small cell lung cancer and prostate cancer. Main body Taxotere, is a docetaxel formulation solubilized in tween 80 and 13% ethanol solution. It is effective as a chemotherapeutic agent but has numerous toxic effects due to the ethanol and polysorbate. Aside from this, challenges with administration during mixing of the docetaxel with the diluent exist. Poor mixing results in gel formation while addition of the drug mix to an infusion may result in micelle formation. These challenges have necessitated remodeling of the currently available docetaxel formulation, but none has made it to clinical setting as an alternative. Efforts have also been made to develop oral docetaxel formulation to ease administration of the drug. Attempts have also been made to develop other dosage forms, notably transdermal formulations and implants to target cancer cells while avoiding systemic side effects. Formulation methods such as nanoformulation, drug coupling with other active moieties, 3D fabrication as well as electrospinning have been employed. Conclusions Development of novel formulations of docetaxel for different chemotherapeutic needs appears promising with some formulations currently in clinical trials. Exploring other drug formulation techniques such as the use of 2D LDH may produce novel anticancer formulations in the future. |
| first_indexed | 2024-12-12T03:05:39Z |
| format | Article |
| id | doaj.art-18f5a140682d48c89722c89c7846e64c |
| institution | Directory Open Access Journal |
| issn | 2522-8307 |
| language | English |
| last_indexed | 2024-12-12T03:05:39Z |
| publishDate | 2022-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Bulletin of the National Research Centre |
| spelling | doaj.art-18f5a140682d48c89722c89c7846e64c2022-12-22T00:40:31ZengSpringerOpenBulletin of the National Research Centre2522-83072022-06-0146111410.1186/s42269-022-00854-5A multiscale approach to targeted docetaxel formulations: combination therapy, nanotechnology, electrospinning and 3D printing—a reviewKaramot O. Oyediran0Margaret O. Ilomuanya1Chukwuemeka P. Azubuike2Layeni Nurudeen3Faculty of Pharmacy, Pharmaceutics and Pharmaceutical Technology, LUTH, University of LagosFaculty of Pharmacy, Pharmaceutics and Pharmaceutical Technology, LUTH, University of LagosFaculty of Pharmacy, Pharmaceutics and Pharmaceutical Technology, LUTH, University of LagosPharmacy Department, General Hospital, OdanAbstract Background Cancer remains one of the leading causes of death worldwide. Docetaxel, first marketed as ‘Taxotere’, has been approved for use as a chemotherapeutic for management of gastric, breast, neck, head, non-small cell lung cancer and prostate cancer. Main body Taxotere, is a docetaxel formulation solubilized in tween 80 and 13% ethanol solution. It is effective as a chemotherapeutic agent but has numerous toxic effects due to the ethanol and polysorbate. Aside from this, challenges with administration during mixing of the docetaxel with the diluent exist. Poor mixing results in gel formation while addition of the drug mix to an infusion may result in micelle formation. These challenges have necessitated remodeling of the currently available docetaxel formulation, but none has made it to clinical setting as an alternative. Efforts have also been made to develop oral docetaxel formulation to ease administration of the drug. Attempts have also been made to develop other dosage forms, notably transdermal formulations and implants to target cancer cells while avoiding systemic side effects. Formulation methods such as nanoformulation, drug coupling with other active moieties, 3D fabrication as well as electrospinning have been employed. Conclusions Development of novel formulations of docetaxel for different chemotherapeutic needs appears promising with some formulations currently in clinical trials. Exploring other drug formulation techniques such as the use of 2D LDH may produce novel anticancer formulations in the future.https://doi.org/10.1186/s42269-022-00854-5CancerMetastatic cancerPolymeric docetaxel nanoformulationsCombined chemotherapeuticsTargeted anticancer formulationElectrospunned fibers |
| spellingShingle | Karamot O. Oyediran Margaret O. Ilomuanya Chukwuemeka P. Azubuike Layeni Nurudeen A multiscale approach to targeted docetaxel formulations: combination therapy, nanotechnology, electrospinning and 3D printing—a review Bulletin of the National Research Centre Cancer Metastatic cancer Polymeric docetaxel nanoformulations Combined chemotherapeutics Targeted anticancer formulation Electrospunned fibers |
| title | A multiscale approach to targeted docetaxel formulations: combination therapy, nanotechnology, electrospinning and 3D printing—a review |
| title_full | A multiscale approach to targeted docetaxel formulations: combination therapy, nanotechnology, electrospinning and 3D printing—a review |
| title_fullStr | A multiscale approach to targeted docetaxel formulations: combination therapy, nanotechnology, electrospinning and 3D printing—a review |
| title_full_unstemmed | A multiscale approach to targeted docetaxel formulations: combination therapy, nanotechnology, electrospinning and 3D printing—a review |
| title_short | A multiscale approach to targeted docetaxel formulations: combination therapy, nanotechnology, electrospinning and 3D printing—a review |
| title_sort | multiscale approach to targeted docetaxel formulations combination therapy nanotechnology electrospinning and 3d printing a review |
| topic | Cancer Metastatic cancer Polymeric docetaxel nanoformulations Combined chemotherapeutics Targeted anticancer formulation Electrospunned fibers |
| url | https://doi.org/10.1186/s42269-022-00854-5 |
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