TRPA1 Expression in Synovial Sarcoma May Support Neural Origin
Synovial sarcoma (SS) is a malignant mesenchymal soft tissue neoplasm. Despite its name, the cells of origin are not synovial cells, but rather neural, myogenic, or multipotent mesenchymal stem cells have been proposed as possible cells originators. Unlike other sarcomas, an unusual presentation of...
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MDPI AG
2020-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/10/1446 |
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| author | Francesco De Logu Filippo Ugolini Chiara Caporalini Annarita Palomba Sara Simi Francesca Portelli Domenico Andrea Campanacci Giovanni Beltrami Daniela Massi Romina Nassini |
| author_facet | Francesco De Logu Filippo Ugolini Chiara Caporalini Annarita Palomba Sara Simi Francesca Portelli Domenico Andrea Campanacci Giovanni Beltrami Daniela Massi Romina Nassini |
| author_sort | Francesco De Logu |
| collection | DOAJ |
| description | Synovial sarcoma (SS) is a malignant mesenchymal soft tissue neoplasm. Despite its name, the cells of origin are not synovial cells, but rather neural, myogenic, or multipotent mesenchymal stem cells have been proposed as possible cells originators. Unlike other sarcomas, an unusual presentation of long-term pain at the tumor site has been documented, but the exact mechanisms have not been fully clarified yet. The transient receptor potential ankyrin 1 (TRPA1) is a nonselective cation channel mainly expressed in primary sensory neurons, where it functions as a pain sensor. TRPA1 have also been described in multiple non-excitable cells, including those derived from neural crest stem cells such as glial cells and, in particular, Schwann cell oligodendrocytes and astrocytes. We evaluated TRPA1 expression in SS. We selected a cohort of 41 SSs, and by immunohistochemistry, we studied TRPA1 expression<b>. </b>TRPA1 was found in 92.6% of cases. Triple TRPA1/pS100/SOX10 and TRPA1/SLUG/SNAIL staining strongly supports a neural origin of SS. TRPA1 positivity was also observed in a subset of cases negative with pS100, SOX10 and/or SLUG/SNAIL, and these divergent phenotypes may reflect a process of tumor plasticity and dedifferentiation of neural-derived SSs. Given the functional diversity of TRPA1 and its expression in neuronal and non-neuronal multipotent neural crest stem cells, it remains to be determined whether TRPA1 expression in SSs neoplastic cells plays a role in the molecular mechanism associated with premonitory pain symptoms and tumor progression. |
| first_indexed | 2024-03-10T15:36:07Z |
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| id | doaj.art-18f5a1acfe9b46fdaceed05a87e7bbb2 |
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| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T15:36:07Z |
| publishDate | 2020-10-01 |
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| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-18f5a1acfe9b46fdaceed05a87e7bbb22023-11-20T17:12:34ZengMDPI AGBiomolecules2218-273X2020-10-011010144610.3390/biom10101446TRPA1 Expression in Synovial Sarcoma May Support Neural OriginFrancesco De Logu0Filippo Ugolini1Chiara Caporalini2Annarita Palomba3Sara Simi4Francesca Portelli5Domenico Andrea Campanacci6Giovanni Beltrami7Daniela Massi8Romina Nassini9Section of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, 50139 Florence, ItalySection of Pathological Anatomy, Department of Health Sciences, University of Florence, 50139 Florence, ItalyPathology Unit, Meyer Children’s Hospital, 50139 Florence, ItalySection of Pathological Anatomy, Department of Health Sciences, University of Florence, 50139 Florence, ItalySection of Pathological Anatomy, Department of Health Sciences, University of Florence, 50139 Florence, ItalySection of Pathological Anatomy, Department of Health Sciences, University of Florence, 50139 Florence, ItalyOrthopedics and Traumatology Section, Department of Health Sciences, University of Florence, 50139 Florence, ItalyOrthopedics and Traumatology Section, Department of Health Sciences, University of Florence, 50139 Florence, ItalySection of Pathological Anatomy, Department of Health Sciences, University of Florence, 50139 Florence, ItalySection of Clinical Pharmacology and Oncology, Department of Health Sciences, University of Florence, 50139 Florence, ItalySynovial sarcoma (SS) is a malignant mesenchymal soft tissue neoplasm. Despite its name, the cells of origin are not synovial cells, but rather neural, myogenic, or multipotent mesenchymal stem cells have been proposed as possible cells originators. Unlike other sarcomas, an unusual presentation of long-term pain at the tumor site has been documented, but the exact mechanisms have not been fully clarified yet. The transient receptor potential ankyrin 1 (TRPA1) is a nonselective cation channel mainly expressed in primary sensory neurons, where it functions as a pain sensor. TRPA1 have also been described in multiple non-excitable cells, including those derived from neural crest stem cells such as glial cells and, in particular, Schwann cell oligodendrocytes and astrocytes. We evaluated TRPA1 expression in SS. We selected a cohort of 41 SSs, and by immunohistochemistry, we studied TRPA1 expression<b>. </b>TRPA1 was found in 92.6% of cases. Triple TRPA1/pS100/SOX10 and TRPA1/SLUG/SNAIL staining strongly supports a neural origin of SS. TRPA1 positivity was also observed in a subset of cases negative with pS100, SOX10 and/or SLUG/SNAIL, and these divergent phenotypes may reflect a process of tumor plasticity and dedifferentiation of neural-derived SSs. Given the functional diversity of TRPA1 and its expression in neuronal and non-neuronal multipotent neural crest stem cells, it remains to be determined whether TRPA1 expression in SSs neoplastic cells plays a role in the molecular mechanism associated with premonitory pain symptoms and tumor progression.https://www.mdpi.com/2218-273X/10/10/1446TRPA1synovial sarcomaneural stem cells |
| spellingShingle | Francesco De Logu Filippo Ugolini Chiara Caporalini Annarita Palomba Sara Simi Francesca Portelli Domenico Andrea Campanacci Giovanni Beltrami Daniela Massi Romina Nassini TRPA1 Expression in Synovial Sarcoma May Support Neural Origin Biomolecules TRPA1 synovial sarcoma neural stem cells |
| title | TRPA1 Expression in Synovial Sarcoma May Support Neural Origin |
| title_full | TRPA1 Expression in Synovial Sarcoma May Support Neural Origin |
| title_fullStr | TRPA1 Expression in Synovial Sarcoma May Support Neural Origin |
| title_full_unstemmed | TRPA1 Expression in Synovial Sarcoma May Support Neural Origin |
| title_short | TRPA1 Expression in Synovial Sarcoma May Support Neural Origin |
| title_sort | trpa1 expression in synovial sarcoma may support neural origin |
| topic | TRPA1 synovial sarcoma neural stem cells |
| url | https://www.mdpi.com/2218-273X/10/10/1446 |
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