Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice
Introduction: The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (LD) schedules...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1225134/full |
| _version_ | 1797691050744086528 |
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| author | Julieta Acosta Manuel T. Crespo Santiago A. Plano Diego A. Golombek Diego A. Golombek Juan J. Chiesa Patricia V. Agostino |
| author_facet | Julieta Acosta Manuel T. Crespo Santiago A. Plano Diego A. Golombek Diego A. Golombek Juan J. Chiesa Patricia V. Agostino |
| author_sort | Julieta Acosta |
| collection | DOAJ |
| description | Introduction: The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (LD) schedules, such as advancing chronic jet lag (CJL), leads to adverse physiological effects and pathologies, and is linked with changes in mood and depressive behaviors in humans and rodent models.Methods: C57BL/6J male mice were subjected to circadian disruption through phase advances of 6 h every 2 days (CJL +6/2). Mice under 12:12-h LD cycle were used as controls. After 8 weeks under these conditions, a battery of behavioral tests was performed to assess if mood-related behaviors were affected.Results: Compared to controls under 24 h LD cycles, mice under CJL presented desynchronization of activity-rest rhythms that led to several behavioral impairments, including a decrease in motivation for food reward, and an increase in anxiety, anhedonia, and depressive-like behavior.Conclusion: Chronic circadian disruption, caused by an experimental CJL protocol, affects mood-related and reward-related behaviors in mice. Understanding the importance of the circadian system and its potential role for disruption due to CJL is important for maintaining good health and well-being. |
| first_indexed | 2024-03-12T02:08:51Z |
| format | Article |
| id | doaj.art-18f601038f854b1b9992b760bb3dcf0f |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-12T02:08:51Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-18f601038f854b1b9992b760bb3dcf0f2023-09-06T17:18:01ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-09-011410.3389/fphys.2023.12251341225134Chronic jet lag reduces motivation and affects other mood-related behaviors in male miceJulieta Acosta0Manuel T. Crespo1Santiago A. Plano2Diego A. Golombek3Diego A. Golombek4Juan J. Chiesa5Patricia V. Agostino6Department of Science and Technology, Universidad Nacional de Quilmes/CONICET, Buenos Aires, ArgentinaDepartment of Science and Technology, Universidad Nacional de Quilmes/CONICET, Buenos Aires, ArgentinaInstitute for Biomedical Research (BIOMED), Universidad Católica Argentina (UCA)/CONICET, Buenos Aires, ArgentinaDepartment of Science and Technology, Universidad Nacional de Quilmes/CONICET, Buenos Aires, ArgentinaLaboratorio Interdisciplinario del Tiempo (LITERA), Universidad de San Andrés/CONICET, Buenos Aires, ArgentinaDepartment of Science and Technology, Universidad Nacional de Quilmes/CONICET, Buenos Aires, ArgentinaDepartment of Science and Technology, Universidad Nacional de Quilmes/CONICET, Buenos Aires, ArgentinaIntroduction: The circadian system regulates various physiological processes such as sleep-wake cycles, hormone secretion, metabolism, and the reaction to both natural and drug-based rewards. Chronic disruption of the circadian system caused by unsteady synchronization with light-dark (LD) schedules, such as advancing chronic jet lag (CJL), leads to adverse physiological effects and pathologies, and is linked with changes in mood and depressive behaviors in humans and rodent models.Methods: C57BL/6J male mice were subjected to circadian disruption through phase advances of 6 h every 2 days (CJL +6/2). Mice under 12:12-h LD cycle were used as controls. After 8 weeks under these conditions, a battery of behavioral tests was performed to assess if mood-related behaviors were affected.Results: Compared to controls under 24 h LD cycles, mice under CJL presented desynchronization of activity-rest rhythms that led to several behavioral impairments, including a decrease in motivation for food reward, and an increase in anxiety, anhedonia, and depressive-like behavior.Conclusion: Chronic circadian disruption, caused by an experimental CJL protocol, affects mood-related and reward-related behaviors in mice. Understanding the importance of the circadian system and its potential role for disruption due to CJL is important for maintaining good health and well-being.https://www.frontiersin.org/articles/10.3389/fphys.2023.1225134/fullcircadian systemchronic jet lagdepressionmotivationmood-related behaviors |
| spellingShingle | Julieta Acosta Manuel T. Crespo Santiago A. Plano Diego A. Golombek Diego A. Golombek Juan J. Chiesa Patricia V. Agostino Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice Frontiers in Physiology circadian system chronic jet lag depression motivation mood-related behaviors |
| title | Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice |
| title_full | Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice |
| title_fullStr | Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice |
| title_full_unstemmed | Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice |
| title_short | Chronic jet lag reduces motivation and affects other mood-related behaviors in male mice |
| title_sort | chronic jet lag reduces motivation and affects other mood related behaviors in male mice |
| topic | circadian system chronic jet lag depression motivation mood-related behaviors |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1225134/full |
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