Comparison of different carotid stent designs in endovascular therapy of severe carotid artery stenosis
Background: One of the major periprocedural risks of carotid artery stenting is embolism caused either by plaque debris or by local thrombus forming. Double-layer micromesh stent design has shown to lower the chance of debris embolism but might have a slightly higher risk of local thrombus forming....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Clinical and Translational Neuroscience |
| Online Access: | https://doi.org/10.1177/2514183X20932417 |
| _version_ | 1818583436941590528 |
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| author | Philipp Gruber Jatta Berberat Timo Kahles Javier Anon Michael Diepers Krassen Nedeltchev Luca Remonda |
| author_facet | Philipp Gruber Jatta Berberat Timo Kahles Javier Anon Michael Diepers Krassen Nedeltchev Luca Remonda |
| author_sort | Philipp Gruber |
| collection | DOAJ |
| description | Background: One of the major periprocedural risks of carotid artery stenting is embolism caused either by plaque debris or by local thrombus forming. Double-layer micromesh stent design has shown to lower the chance of debris embolism but might have a slightly higher risk of local thrombus forming. Thus, we compared two different stent designs regarding safety and outcome profile in elective patients with high-grade carotid artery stenosis using a self-expanding, double-layer micromesh carotid stent system (DLCS) or a self-expanding hybrid carotid stent system (HCS). Methods: A single-center, open-label, retrospective cohort study of 67 consecutive, elective patients with high-grade symptomatic and asymptomatic carotid stenosis was executed at a comprehensive stroke center. Outcome measures were reocclusion rate, periprocedural symptomatic ischemic events, as well as other periprocedural complications, and recurrent stroke and mortality at 30 days’ follow-up. Results: Thirty-two patients (24% women, median age 75 years (interquartile range (IQR) 71–80) were treated with DLCS, and 35 patients (29% women, median age 71 years (IQR 63–76) years) with HCS. In both groups, pretreatment carotid stenosis degree was similar (median NASCET of 80%). Successful deployment was achieved in all cases without technical failure, and both groups did not differ in reocclusion rates, recurrent stroke, and mortality within 30 days. Conclusions: DCLS and HCS revealed to have similar safety and outcome profile in elective patients with high-grade symptomatic as well as asymptomatic carotid artery stenosis. |
| first_indexed | 2024-12-16T08:05:16Z |
| format | Article |
| id | doaj.art-18f6fc316aa04752b79ab625e7b05632 |
| institution | Directory Open Access Journal |
| issn | 2514-183X |
| language | English |
| last_indexed | 2024-12-16T08:05:16Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinical and Translational Neuroscience |
| spelling | doaj.art-18f6fc316aa04752b79ab625e7b056322022-12-21T22:38:29ZengMDPI AGClinical and Translational Neuroscience2514-183X2020-06-01410.1177/2514183X20932417Comparison of different carotid stent designs in endovascular therapy of severe carotid artery stenosisPhilipp Gruber0Jatta Berberat1Timo Kahles2Javier Anon3Michael Diepers4Krassen Nedeltchev5Luca Remonda6 Department of Neuroradiology, Kantonsspital Aarau, Aarau, Switzerland Department of Neuroradiology, Kantonsspital Aarau, Aarau, Switzerland Department of Neurology, Kantonsspital Aarau, Aarau, Switzerland Department of Neuroradiology, Kantonsspital Aarau, Aarau, Switzerland Department of Neuroradiology, Kantonsspital Aarau, Aarau, Switzerland University Berne, Berne, Switzerland University Berne, Berne, SwitzerlandBackground: One of the major periprocedural risks of carotid artery stenting is embolism caused either by plaque debris or by local thrombus forming. Double-layer micromesh stent design has shown to lower the chance of debris embolism but might have a slightly higher risk of local thrombus forming. Thus, we compared two different stent designs regarding safety and outcome profile in elective patients with high-grade carotid artery stenosis using a self-expanding, double-layer micromesh carotid stent system (DLCS) or a self-expanding hybrid carotid stent system (HCS). Methods: A single-center, open-label, retrospective cohort study of 67 consecutive, elective patients with high-grade symptomatic and asymptomatic carotid stenosis was executed at a comprehensive stroke center. Outcome measures were reocclusion rate, periprocedural symptomatic ischemic events, as well as other periprocedural complications, and recurrent stroke and mortality at 30 days’ follow-up. Results: Thirty-two patients (24% women, median age 75 years (interquartile range (IQR) 71–80) were treated with DLCS, and 35 patients (29% women, median age 71 years (IQR 63–76) years) with HCS. In both groups, pretreatment carotid stenosis degree was similar (median NASCET of 80%). Successful deployment was achieved in all cases without technical failure, and both groups did not differ in reocclusion rates, recurrent stroke, and mortality within 30 days. Conclusions: DCLS and HCS revealed to have similar safety and outcome profile in elective patients with high-grade symptomatic as well as asymptomatic carotid artery stenosis.https://doi.org/10.1177/2514183X20932417 |
| spellingShingle | Philipp Gruber Jatta Berberat Timo Kahles Javier Anon Michael Diepers Krassen Nedeltchev Luca Remonda Comparison of different carotid stent designs in endovascular therapy of severe carotid artery stenosis Clinical and Translational Neuroscience |
| title | Comparison of different carotid stent designs in endovascular therapy of severe carotid artery stenosis |
| title_full | Comparison of different carotid stent designs in endovascular therapy of severe carotid artery stenosis |
| title_fullStr | Comparison of different carotid stent designs in endovascular therapy of severe carotid artery stenosis |
| title_full_unstemmed | Comparison of different carotid stent designs in endovascular therapy of severe carotid artery stenosis |
| title_short | Comparison of different carotid stent designs in endovascular therapy of severe carotid artery stenosis |
| title_sort | comparison of different carotid stent designs in endovascular therapy of severe carotid artery stenosis |
| url | https://doi.org/10.1177/2514183X20932417 |
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