Cell-Centric View of Apoptosis and Apoptotic Cell Death-Inducing Antitumoral Strategies
Programmed cell death and especially apoptotic cell death, occurs under physiological conditions and is also desirable under pathological circumstances. However, the more we learn about cellular signaling cascades, the less plausible it becomes to find restricted and well-limited signaling pathways....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-03-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/3/1/1042/ |
| _version_ | 1797701507087335424 |
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| author | Maria Dolores Boyano Aintzane Apraiz Aintzane Asumendi |
| author_facet | Maria Dolores Boyano Aintzane Apraiz Aintzane Asumendi |
| author_sort | Maria Dolores Boyano |
| collection | DOAJ |
| description | Programmed cell death and especially apoptotic cell death, occurs under physiological conditions and is also desirable under pathological circumstances. However, the more we learn about cellular signaling cascades, the less plausible it becomes to find restricted and well-limited signaling pathways. In this context, an extensive description of pathway-connections is necessary in order to point out the main regulatory molecules as well as to select the most appropriate therapeutic targets. On the other hand, irregularities in programmed cell death pathways often lead to tumor development and cancer-related mortality is projected to continue increasing despite the effort to develop more active and selective antitumoral compounds. In fact, tumor cell plasticity represents a major challenge in chemotherapy and improvement on anticancer therapies seems to rely on appropriate drug combinations. An overview of the current status regarding apoptotic pathways as well as available chemotherapeutic compounds provides a new perspective of possible future anticancer strategies. |
| first_indexed | 2024-03-12T04:36:42Z |
| format | Article |
| id | doaj.art-18f71396f57e43e7817ba5e2f7c914b1 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T04:36:42Z |
| publishDate | 2011-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-18f71396f57e43e7817ba5e2f7c914b12023-09-03T09:54:35ZengMDPI AGCancers2072-66942011-03-01311042108010.3390/cancers3011042Cell-Centric View of Apoptosis and Apoptotic Cell Death-Inducing Antitumoral StrategiesMaria Dolores BoyanoAintzane ApraizAintzane AsumendiProgrammed cell death and especially apoptotic cell death, occurs under physiological conditions and is also desirable under pathological circumstances. However, the more we learn about cellular signaling cascades, the less plausible it becomes to find restricted and well-limited signaling pathways. In this context, an extensive description of pathway-connections is necessary in order to point out the main regulatory molecules as well as to select the most appropriate therapeutic targets. On the other hand, irregularities in programmed cell death pathways often lead to tumor development and cancer-related mortality is projected to continue increasing despite the effort to develop more active and selective antitumoral compounds. In fact, tumor cell plasticity represents a major challenge in chemotherapy and improvement on anticancer therapies seems to rely on appropriate drug combinations. An overview of the current status regarding apoptotic pathways as well as available chemotherapeutic compounds provides a new perspective of possible future anticancer strategies.http://www.mdpi.com/2072-6694/3/1/1042/apoptosisclassical-chemotherapytargeted-chemotherapy |
| spellingShingle | Maria Dolores Boyano Aintzane Apraiz Aintzane Asumendi Cell-Centric View of Apoptosis and Apoptotic Cell Death-Inducing Antitumoral Strategies Cancers apoptosis classical-chemotherapy targeted-chemotherapy |
| title | Cell-Centric View of Apoptosis and Apoptotic Cell Death-Inducing Antitumoral Strategies |
| title_full | Cell-Centric View of Apoptosis and Apoptotic Cell Death-Inducing Antitumoral Strategies |
| title_fullStr | Cell-Centric View of Apoptosis and Apoptotic Cell Death-Inducing Antitumoral Strategies |
| title_full_unstemmed | Cell-Centric View of Apoptosis and Apoptotic Cell Death-Inducing Antitumoral Strategies |
| title_short | Cell-Centric View of Apoptosis and Apoptotic Cell Death-Inducing Antitumoral Strategies |
| title_sort | cell centric view of apoptosis and apoptotic cell death inducing antitumoral strategies |
| topic | apoptosis classical-chemotherapy targeted-chemotherapy |
| url | http://www.mdpi.com/2072-6694/3/1/1042/ |
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