| Summary: | Scientific studies about the antibacterial effects of honeydew honey produced by the stingless bee are very limited. In this study, the antibacterial activities of 46 blossom and honeydew honeys produced by both honey bees and stingless bees were evaluated and compared. All bacterial isolates showed varying degrees of susceptibility to blossom and honeydew honeys produced by the honey bee (<i>Apis cerana</i>) and stingless bee (<i>Heterotrigona itama</i> and <i>Geniotrigona thoracica</i>) in agar-well diffusion. All stingless bee honeys managed to inhibit all the isolates but only four out of 23 honey bee honeys achieved that. In comparison with <i>Staphylococcus aureus</i>, <i>Escherichia coli</i> was found to be more susceptible to the antibacterial effects of honey. Bactericidal effects of stingless bee honeys on <i>E. coli</i> were determined with the measurement of endotoxins released due to cell lysis. Based on the outcomes, the greatest antibacterial effects were observed in honeydew honey produced by <i>H. itama</i>. Scanning electron microscopic images revealed the morphological alteration and destruction of <i>E. coli</i> due to the action of this honey. The combination of this honey with antibiotics showed synergistic inhibitory effects on <i>E. coli</i> clinical isolates. This study revealed that honeydew honey produced by <i>H. itama</i> stingless bee has promising antibacterial activity against pathogenic bacteria, including antibiotic resistant strains.
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