SARS-CoV-2 and Anti-Cardiolipin Antibodies
The current COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to distinct diagnostic and management challenges for front-line healthcare workers. The risk of excessive coagulation activation leading to a cascade of thrombotic events in critically il...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-12-01
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| Series: | Clinical Medicine Insights: Case Reports |
| Online Access: | https://doi.org/10.1177/1179547620980381 |
| _version_ | 1818730717336567808 |
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| author | Mazen Jizzini Mohsin Shah Kehua Zhou |
| author_facet | Mazen Jizzini Mohsin Shah Kehua Zhou |
| author_sort | Mazen Jizzini |
| collection | DOAJ |
| description | The current COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to distinct diagnostic and management challenges for front-line healthcare workers. The risk of excessive coagulation activation leading to a cascade of thrombotic events in critically ill patients with SARS-CoV-2 is now well reported. We discuss a recent case of COVID-19 with concurrent acute pulmonary embolism and a positive cardiolipin antibody (IgM). The presence of antiphospholipid antibodies is key to diagnosing antiphospholipid syndrome (APS). However, their presence can be transient or persistent after viral infections. Serial inflammatory markers in conjunction with anti-phospholipid antibody testing is critical for the diagnosis of APS in this emerging patient population. Our case report reviews details suggestive of APS in the setting of SARS-CoV-2 and aims to provide clinical diagnostic clues that could help warrant further workup and assist with management strategies. |
| first_indexed | 2024-12-17T23:06:13Z |
| format | Article |
| id | doaj.art-18f7c62ef09548699acebfa615503e08 |
| institution | Directory Open Access Journal |
| issn | 1179-5476 |
| language | English |
| last_indexed | 2024-12-17T23:06:13Z |
| publishDate | 2020-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical Medicine Insights: Case Reports |
| spelling | doaj.art-18f7c62ef09548699acebfa615503e082022-12-21T21:29:16ZengSAGE PublishingClinical Medicine Insights: Case Reports1179-54762020-12-011310.1177/1179547620980381SARS-CoV-2 and Anti-Cardiolipin AntibodiesMazen Jizzini0Mohsin Shah1Kehua Zhou2Department of Medicine, State University of New York at Buffalo, USACenter for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, USADepartment of Medicine, State University of New York at Buffalo, USAThe current COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to distinct diagnostic and management challenges for front-line healthcare workers. The risk of excessive coagulation activation leading to a cascade of thrombotic events in critically ill patients with SARS-CoV-2 is now well reported. We discuss a recent case of COVID-19 with concurrent acute pulmonary embolism and a positive cardiolipin antibody (IgM). The presence of antiphospholipid antibodies is key to diagnosing antiphospholipid syndrome (APS). However, their presence can be transient or persistent after viral infections. Serial inflammatory markers in conjunction with anti-phospholipid antibody testing is critical for the diagnosis of APS in this emerging patient population. Our case report reviews details suggestive of APS in the setting of SARS-CoV-2 and aims to provide clinical diagnostic clues that could help warrant further workup and assist with management strategies.https://doi.org/10.1177/1179547620980381 |
| spellingShingle | Mazen Jizzini Mohsin Shah Kehua Zhou SARS-CoV-2 and Anti-Cardiolipin Antibodies Clinical Medicine Insights: Case Reports |
| title | SARS-CoV-2 and Anti-Cardiolipin Antibodies |
| title_full | SARS-CoV-2 and Anti-Cardiolipin Antibodies |
| title_fullStr | SARS-CoV-2 and Anti-Cardiolipin Antibodies |
| title_full_unstemmed | SARS-CoV-2 and Anti-Cardiolipin Antibodies |
| title_short | SARS-CoV-2 and Anti-Cardiolipin Antibodies |
| title_sort | sars cov 2 and anti cardiolipin antibodies |
| url | https://doi.org/10.1177/1179547620980381 |
| work_keys_str_mv | AT mazenjizzini sarscov2andanticardiolipinantibodies AT mohsinshah sarscov2andanticardiolipinantibodies AT kehuazhou sarscov2andanticardiolipinantibodies |