An Ex Vivo and In Silico Study Providing Insights into the Interplay of Circulating miRNAs Level, Platelet Reactivity and Thrombin Generation: Looking beyond Traditional Pharmacogenetics

An Ex Vivo and In Silico Study Providing Insights into the Interplay of Circulating miRNAs Level, Platelet Reactivity and Thrombin Generation: Looking beyond Traditional Pharmacogenetics

Platelet reactivity (PR), a key pharmacodynamic (PD) component of the action of antiplatelet drugs in cardiovascular disease (CVD) patients, is highly variable. PR is associated with occurrence or recurrence of thrombotic and bleeding events, but this association is modulated by several factors. Con...

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Bibliographic Details
Main Authors: Alix Garcia, Sylvie Dunoyer-Geindre, Séverine Nolli, Jean-Luc Reny, Pierre Fontana
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Journal of Personalized Medicine
Subjects:
miRNA
biomarker
cardiovascular disorders
platelet aggregation
thrombin generation
Online Access:https://www.mdpi.com/2075-4426/11/5/323

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