Tetanus toxin fragments and Bcl-2 fusion proteins: cytoprotection and retrograde axonal migration

Tetanus toxin fragments and Bcl-2 fusion proteins: cytoprotection and retrograde axonal migration

Abstract Background Tetanus neurotoxin (TeNT) is taken up at nerve terminals and undergoes retrograde migration. The toxic properties of TeNT reside in the toxin light chain (L), but like complete TeNT, the TeNT heavy chain (TTH) and the C-terminal domain (TTC) alone can bind and enter into neurons....

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Bibliographic Details
Main Authors: Yasuhiro Watanabe, Takashi Matsuba, Mami Nakanishi, Mio Une, Ritsuko Hanajima, Kenji Nakashima
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Biotechnology
Subjects:
Apoptosis
Bcl-2
TeNT
TTC
Fusion protein
Neuron
Online Access:http://link.springer.com/article/10.1186/s12896-018-0452-z

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