L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period
Background: The increased use of body reserves observed during peripartum leads to higher needs of L-carnitine by cows, which is restrictive under the production conditions of Colombian high tropics. Objective: To evaluate the lipotropic potential of L-carnitine in Holstein dairy cows during the tra...
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| Format: | Article |
| Language: | English |
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Universidad de Antioquia
2019-07-01
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| Series: | Revista Colombiana de Ciencias Pecuarias |
| Subjects: | |
| Online Access: | https://revistas.udea.edu.co/index.php/rccp/article/view/337875 |
| _version_ | 1818693058985721856 |
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| author | Rubén D. Galvis Liset V. Madrid Nicolás Ramírez-Vásquez |
| author_facet | Rubén D. Galvis Liset V. Madrid Nicolás Ramírez-Vásquez |
| author_sort | Rubén D. Galvis |
| collection | DOAJ |
| description | Background: The increased use of body reserves observed during peripartum leads to higher needs of L-carnitine by cows, which is restrictive under the production conditions of Colombian high tropics. Objective: To evaluate the lipotropic potential of L-carnitine in Holstein dairy cows during the transition period to lactation. Methods: Twenty-one Holstein cows were fed 0, 100, or 200 g/d L-carnitine fumarate from d 260 of gestation to d 20 postpartum. Hepatic triacylglycerides concentration, total carnitine, free carnitine, acylcarnitine, and serum levels of non-esterified fatty acids (NEFA), β-hydroxybutyrate (β-HB) and urea were determined by spectrophotometry. Repeated measures analysis was used to determine the effects of dose, measurement period, and their interactions. Results: Hepatic triglycerides and the different forms of carnitine showed no difference between sampling periods (p>0.05). Hepatic triglycerides concentration was low and decreased in response to 200 g/d L-carnitine fumarate supplementation (p<0.05). This decrease in hepatic triglycerides could be due to increased fatty acid oxidation. L-carnitine supplementation significantly increased (p<0.05) blood urea concentration, possibly through stimulation of the urea cycle, as previously described in other species. Conclusion: Supplementation with L-carnitine decreased the hepatic concentration of triglycerides, possibly due to increased liver oxidation of fatty acids. |
| first_indexed | 2024-12-17T13:07:39Z |
| format | Article |
| id | doaj.art-18fb5c262fc141e8ba41f6d64e658584 |
| institution | Directory Open Access Journal |
| issn | 2256-2958 |
| language | English |
| last_indexed | 2024-12-17T13:07:39Z |
| publishDate | 2019-07-01 |
| publisher | Universidad de Antioquia |
| record_format | Article |
| series | Revista Colombiana de Ciencias Pecuarias |
| spelling | doaj.art-18fb5c262fc141e8ba41f6d64e6585842022-12-21T21:47:12ZengUniversidad de AntioquiaRevista Colombiana de Ciencias Pecuarias2256-29582019-07-0132316617410.17533/udea.rccp.v32n3a0136391L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition periodRubén D. Galvis0Liset V. Madrid1Nicolás Ramírez-Vásquez2National University of ColombiaNational University of ColombiaUniversity of AntioquiaBackground: The increased use of body reserves observed during peripartum leads to higher needs of L-carnitine by cows, which is restrictive under the production conditions of Colombian high tropics. Objective: To evaluate the lipotropic potential of L-carnitine in Holstein dairy cows during the transition period to lactation. Methods: Twenty-one Holstein cows were fed 0, 100, or 200 g/d L-carnitine fumarate from d 260 of gestation to d 20 postpartum. Hepatic triacylglycerides concentration, total carnitine, free carnitine, acylcarnitine, and serum levels of non-esterified fatty acids (NEFA), β-hydroxybutyrate (β-HB) and urea were determined by spectrophotometry. Repeated measures analysis was used to determine the effects of dose, measurement period, and their interactions. Results: Hepatic triglycerides and the different forms of carnitine showed no difference between sampling periods (p>0.05). Hepatic triglycerides concentration was low and decreased in response to 200 g/d L-carnitine fumarate supplementation (p<0.05). This decrease in hepatic triglycerides could be due to increased fatty acid oxidation. L-carnitine supplementation significantly increased (p<0.05) blood urea concentration, possibly through stimulation of the urea cycle, as previously described in other species. Conclusion: Supplementation with L-carnitine decreased the hepatic concentration of triglycerides, possibly due to increased liver oxidation of fatty acids.https://revistas.udea.edu.co/index.php/rccp/article/view/337875dairy cowslipid metabolisml-carnitinelipidosislipotropic factorsmetabolic disordersperipartum |
| spellingShingle | Rubén D. Galvis Liset V. Madrid Nicolás Ramírez-Vásquez L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period Revista Colombiana de Ciencias Pecuarias dairy cows lipid metabolism l-carnitine lipidosis lipotropic factors metabolic disorders peripartum |
| title | L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period |
| title_full | L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period |
| title_fullStr | L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period |
| title_full_unstemmed | L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period |
| title_short | L-carnitine supplementation descreases hepatic triglyceride accumulation in Holstein cows during the transition period |
| title_sort | l carnitine supplementation descreases hepatic triglyceride accumulation in holstein cows during the transition period |
| topic | dairy cows lipid metabolism l-carnitine lipidosis lipotropic factors metabolic disorders peripartum |
| url | https://revistas.udea.edu.co/index.php/rccp/article/view/337875 |
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