Virulence of Mycobacterium tuberculosis Clinical Isolates Is Associated With Sputum Pre-treatment Bacterial Load, Lineage, Survival in Macrophages, and Cytokine Response

Virulence of Mycobacterium tuberculosis Clinical Isolates Is Associated With Sputum Pre-treatment Bacterial Load, Lineage, Survival in Macrophages, and Cytokine Response

It is uncertain whether differences in Mycobacterium tuberculosis (Mtb) virulence defined in vitro influence clinical tuberculosis pathogenesis, transmission, and mortality. We primarily used a macrophage lysis model to characterize the virulence of Mtb isolates collected from 153 Vietnamese adults...

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Bibliographic Details
Main Authors: Trinh T. B. Tram, Hoang N. Nhung, Srinivasan Vijay, Hoang T. Hai, Do D. A. Thu, Vu T. N. Ha, Tran D. Dinh, Philip M. Ashton, Nguyen T. Hanh, Nguyen H. Phu, Guy E. Thwaites, Nguyen T. T. Thuong
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Mycobacterium tuberculosis
clinical isolates
virulence
sputum
bacterial growth
cytokine response
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00417/full

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