Immunogenicity of Catch-Up Immunization with Conventional Inactivated Polio Vaccine among Japanese Adults
Most Japanese adults are vaccinated twice with the Sabin trivalent oral polio vaccine. Booster vaccination is recommended for Japanese travelers to polio-endemic/high-risk countries. We assessed the catch-up immunization of healthy Japanese adults aged ≥20 years with two doses of standalone conventi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/10/12/2160 |
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| author | Shinji Fukushima Takashi Nakano Hiroyuki Shimizu Atsuo Hamada |
| author_facet | Shinji Fukushima Takashi Nakano Hiroyuki Shimizu Atsuo Hamada |
| author_sort | Shinji Fukushima |
| collection | DOAJ |
| description | Most Japanese adults are vaccinated twice with the Sabin trivalent oral polio vaccine. Booster vaccination is recommended for Japanese travelers to polio-endemic/high-risk countries. We assessed the catch-up immunization of healthy Japanese adults aged ≥20 years with two doses of standalone conventional inactivated polio vaccine (cIPV). Immunogenicity was evaluated by serum neutralization titers (pre-booster vaccination, 4–6 weeks after each vaccination) against type 1, 2, and 3 poliovirus strains. The participants were 61 healthy Japanese adults (26 men/35 women; mean age ± standard deviation age 35.8 ± 8.0 years). Seropositivity rates (percentage of participants with anti-poliovirus antibody titers ≥1:8) pre-vaccination were 88.5%, 95.1%, and 52.5% for Sabin strains (type 1, 2, and 3); 72.1%, 93.4%, and 31.1% for virulent poliovirus strains (type 1: Mahoney; type 2: MEF-1; and type 3: Saukett); and 93.4%, 93.4%, 93.4%, and 88.5% for type 2 vaccine-derived poliovirus strains (SV3128, SV3130, 11,196, and 11,198). After one cIPV dose, all seropositivity rates increased to 98.4–100.0%. After two cIPV doses, the seropositivity rates reached 100% for all strains. cIPV was well tolerated, with no safety concerns. Catch-up immunization with standalone cIPV induced robust immune responses in Japanese adults, indicating that one booster dose boosted serum-neutralizing antibodies to many strains. |
| first_indexed | 2024-03-09T15:45:26Z |
| format | Article |
| id | doaj.art-18fed01c0b4f464b8aa1d6943d95445f |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T15:45:26Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-18fed01c0b4f464b8aa1d6943d95445f2023-11-24T18:33:49ZengMDPI AGVaccines2076-393X2022-12-011012216010.3390/vaccines10122160Immunogenicity of Catch-Up Immunization with Conventional Inactivated Polio Vaccine among Japanese AdultsShinji Fukushima0Takashi Nakano1Hiroyuki Shimizu2Atsuo Hamada3Travellers’ Medical Center, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, JapanDepartment of Pediatrics, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701-0192, JapanDepartment of Virology II, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama-shi, Tokyo 208-0011, JapanTravellers’ Medical Center, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, JapanMost Japanese adults are vaccinated twice with the Sabin trivalent oral polio vaccine. Booster vaccination is recommended for Japanese travelers to polio-endemic/high-risk countries. We assessed the catch-up immunization of healthy Japanese adults aged ≥20 years with two doses of standalone conventional inactivated polio vaccine (cIPV). Immunogenicity was evaluated by serum neutralization titers (pre-booster vaccination, 4–6 weeks after each vaccination) against type 1, 2, and 3 poliovirus strains. The participants were 61 healthy Japanese adults (26 men/35 women; mean age ± standard deviation age 35.8 ± 8.0 years). Seropositivity rates (percentage of participants with anti-poliovirus antibody titers ≥1:8) pre-vaccination were 88.5%, 95.1%, and 52.5% for Sabin strains (type 1, 2, and 3); 72.1%, 93.4%, and 31.1% for virulent poliovirus strains (type 1: Mahoney; type 2: MEF-1; and type 3: Saukett); and 93.4%, 93.4%, 93.4%, and 88.5% for type 2 vaccine-derived poliovirus strains (SV3128, SV3130, 11,196, and 11,198). After one cIPV dose, all seropositivity rates increased to 98.4–100.0%. After two cIPV doses, the seropositivity rates reached 100% for all strains. cIPV was well tolerated, with no safety concerns. Catch-up immunization with standalone cIPV induced robust immune responses in Japanese adults, indicating that one booster dose boosted serum-neutralizing antibodies to many strains.https://www.mdpi.com/2076-393X/10/12/2160conventional inactivated polio vaccinetrivalent oral polio vaccinecatch-up immunizationimmunogenicity |
| spellingShingle | Shinji Fukushima Takashi Nakano Hiroyuki Shimizu Atsuo Hamada Immunogenicity of Catch-Up Immunization with Conventional Inactivated Polio Vaccine among Japanese Adults Vaccines conventional inactivated polio vaccine trivalent oral polio vaccine catch-up immunization immunogenicity |
| title | Immunogenicity of Catch-Up Immunization with Conventional Inactivated Polio Vaccine among Japanese Adults |
| title_full | Immunogenicity of Catch-Up Immunization with Conventional Inactivated Polio Vaccine among Japanese Adults |
| title_fullStr | Immunogenicity of Catch-Up Immunization with Conventional Inactivated Polio Vaccine among Japanese Adults |
| title_full_unstemmed | Immunogenicity of Catch-Up Immunization with Conventional Inactivated Polio Vaccine among Japanese Adults |
| title_short | Immunogenicity of Catch-Up Immunization with Conventional Inactivated Polio Vaccine among Japanese Adults |
| title_sort | immunogenicity of catch up immunization with conventional inactivated polio vaccine among japanese adults |
| topic | conventional inactivated polio vaccine trivalent oral polio vaccine catch-up immunization immunogenicity |
| url | https://www.mdpi.com/2076-393X/10/12/2160 |
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