In-depth analysis of the chemical composition, pharmacological effects, pharmacokinetics, and patent history of mangiferin
Introduction: Mangiferin (2-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one) is extracted from different part of plants such seed, peel, and kernels of mango. Methods: In many studies mangiferin was studied for its antidiabetic, antioxidant, antibacterial, anticancer, immunomodulatory, and hy...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031323000416 |
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| author | Monika Kaurav Jovita Kanoujia Madhu Gupta Prachi Goyal Smriti Pant Saksham Rai Kantrol Kumar Sahu Pankaj Bhatt Roma Ghai |
| author_facet | Monika Kaurav Jovita Kanoujia Madhu Gupta Prachi Goyal Smriti Pant Saksham Rai Kantrol Kumar Sahu Pankaj Bhatt Roma Ghai |
| author_sort | Monika Kaurav |
| collection | DOAJ |
| description | Introduction: Mangiferin (2-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one) is extracted from different part of plants such seed, peel, and kernels of mango. Methods: In many studies mangiferin was studied for its antidiabetic, antioxidant, antibacterial, anticancer, immunomodulatory, and hypocholesterolaemia activity. It mainly works by altering the transcription process which further led to inhibition of peroxisome proliferator activated receptor. By preventing the expression of tumor necrosis factor, inducible nitric oxide synthase potential, proliferation, and apoptosis, mangiferin defends against a variety of human malignancies, such as breast, lung, brain, and colon tumours. It could defend against physiological hazards by preventing lipid peroxidation. Results: The present review focuses on an updated account of investigation related to mangiferin's chemo preventive activity, apoptosis induction in cancer cells, potential antioxidative activities, and patent mapping of additional therapeutic aspects. This review also highlights the different molecular targets of Mangiferin, as well as its potential as a polyphenol. Conclusion: From the finding of this review, it was concluded that Mangiferin has versatile pharmacological properties could serves as economic, safe and potential ailment in the treatment of diseases as well as dietary supplements. |
| first_indexed | 2024-04-09T13:21:44Z |
| format | Article |
| id | doaj.art-18fee9260c804c4982a7cc76944e637d |
| institution | Directory Open Access Journal |
| issn | 2667-0313 |
| language | English |
| last_indexed | 2024-04-09T13:21:44Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj.art-18fee9260c804c4982a7cc76944e637d2023-05-11T04:24:56ZengElsevierPhytomedicine Plus2667-03132023-05-0132100445In-depth analysis of the chemical composition, pharmacological effects, pharmacokinetics, and patent history of mangiferinMonika Kaurav0Jovita Kanoujia1Madhu Gupta2Prachi Goyal3Smriti Pant4Saksham Rai5Kantrol Kumar Sahu6Pankaj Bhatt7Roma Ghai8Department of Pharmaceutics, KIET School of Pharmacy, KIET Group of Institutions, Ghaziabad, India; Corresponding author at: KIET school of Pharmacy, KIET Group of Institutions, Ghaziabad, India.Amity Institute of Pharmacy, Amity University Madhya Pradesh (AUMP), Gwalior-474005, Madhya Pradesh, IndiaDepartment of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, Govt. of NCT of Delhi, Pushp Vihar, Sector III, New Delhi, 110017, India; Corresponding author at: Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University, Pushp Vihar, New Delhi, 110017, India.UG Scholars, KIET school of Pharmacy, KIET Group of Institutions, Ghaziabad, UP-201306, IndiaUG Scholars, KIET school of Pharmacy, KIET Group of Institutions, Ghaziabad, UP-201306, IndiaUG Scholars, KIET school of Pharmacy, KIET Group of Institutions, Ghaziabad, UP-201306, IndiaDepartment of Pharmaceutics, GLA University, 17 km Stone, NH-2, Mathura-Delhi Road Mathura, Chaumuhan, Uttar Pradesh 281406, IndiaDepartment of Pharmaceutics, KIET School of Pharmacy, KIET Group of Institutions, Ghaziabad, IndiaDepartment of Pharmaceutics, KIET School of Pharmacy, KIET Group of Institutions, Ghaziabad, IndiaIntroduction: Mangiferin (2-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one) is extracted from different part of plants such seed, peel, and kernels of mango. Methods: In many studies mangiferin was studied for its antidiabetic, antioxidant, antibacterial, anticancer, immunomodulatory, and hypocholesterolaemia activity. It mainly works by altering the transcription process which further led to inhibition of peroxisome proliferator activated receptor. By preventing the expression of tumor necrosis factor, inducible nitric oxide synthase potential, proliferation, and apoptosis, mangiferin defends against a variety of human malignancies, such as breast, lung, brain, and colon tumours. It could defend against physiological hazards by preventing lipid peroxidation. Results: The present review focuses on an updated account of investigation related to mangiferin's chemo preventive activity, apoptosis induction in cancer cells, potential antioxidative activities, and patent mapping of additional therapeutic aspects. This review also highlights the different molecular targets of Mangiferin, as well as its potential as a polyphenol. Conclusion: From the finding of this review, it was concluded that Mangiferin has versatile pharmacological properties could serves as economic, safe and potential ailment in the treatment of diseases as well as dietary supplements.http://www.sciencedirect.com/science/article/pii/S2667031323000416Mangiferin and its derivativesAnti-infectiousAnti-inflammatoryAntioxidantCosmeceuticalChemoprotective etc |
| spellingShingle | Monika Kaurav Jovita Kanoujia Madhu Gupta Prachi Goyal Smriti Pant Saksham Rai Kantrol Kumar Sahu Pankaj Bhatt Roma Ghai In-depth analysis of the chemical composition, pharmacological effects, pharmacokinetics, and patent history of mangiferin Phytomedicine Plus Mangiferin and its derivatives Anti-infectious Anti-inflammatory Antioxidant Cosmeceutical Chemoprotective etc |
| title | In-depth analysis of the chemical composition, pharmacological effects, pharmacokinetics, and patent history of mangiferin |
| title_full | In-depth analysis of the chemical composition, pharmacological effects, pharmacokinetics, and patent history of mangiferin |
| title_fullStr | In-depth analysis of the chemical composition, pharmacological effects, pharmacokinetics, and patent history of mangiferin |
| title_full_unstemmed | In-depth analysis of the chemical composition, pharmacological effects, pharmacokinetics, and patent history of mangiferin |
| title_short | In-depth analysis of the chemical composition, pharmacological effects, pharmacokinetics, and patent history of mangiferin |
| title_sort | in depth analysis of the chemical composition pharmacological effects pharmacokinetics and patent history of mangiferin |
| topic | Mangiferin and its derivatives Anti-infectious Anti-inflammatory Antioxidant Cosmeceutical Chemoprotective etc |
| url | http://www.sciencedirect.com/science/article/pii/S2667031323000416 |
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