Malignancy in a retrospective cohort of 17 patients with Dermatomyositis or Polymyositis in southern Tunisia
Introduction. The prognosis of dermatomyositis (DM)/ polymyositis (PM) in adults is partly related to their association with neoplasia. The aim of our study was to report the epidemiologic, clinical, paraclinical, therapeutic and evolutionary aspects of DM associated with malignancy in patients from...
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| Format: | Article |
| Language: | English |
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Sciendo
2018-12-01
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| Series: | Romanian Journal of Internal Medicine |
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| Online Access: | https://doi.org/10.2478/rjim-2018-0015 |
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| author | Sellami Khadija Mseddi Madiha Snoussi Mouna Gharbi Hela Frikha Faten Salah Rayda Ben Jallouli Moez Marzouk Sameh Masmoudi Abderrahmen Bahloul Zouhir Turki Hamida |
| author_facet | Sellami Khadija Mseddi Madiha Snoussi Mouna Gharbi Hela Frikha Faten Salah Rayda Ben Jallouli Moez Marzouk Sameh Masmoudi Abderrahmen Bahloul Zouhir Turki Hamida |
| author_sort | Sellami Khadija |
| collection | DOAJ |
| description | Introduction. The prognosis of dermatomyositis (DM)/ polymyositis (PM) in adults is partly related to their association with neoplasia. The aim of our study was to report the epidemiologic, clinical, paraclinical, therapeutic and evolutionary aspects of DM associated with malignancy in patients from Sfax, south eastern of Tunisia. Methods. A retrospective cohort study of patients with DM or PM admitted in Dermatology and Internal Medicine Departments of Hedi Chaker University Hospital of Sfax between 1996 and 2015. Cases of DM or PM associated with malignancy were retained. Results. Seventeen cases (13.5%) of DM or PM associated with malignancy were noted. Fourteen patients had DM and 3 patients had PM. The Sex ratio M / F was 0.3 and the mean age at diagnosis was 56.5 years. In DM patients, malignancy preceded the myositis in 64.2% of cases. In PM patients, only one patient was known to have breast cancer and the myositis revealed the cancer for 2 others. Treatment consisted of corticosteroids associated with methotrexate in 4 cases. Outcome was fatal in 5 cases (29.4%), due to the underlying cancer in 3 cases. Swallowing disorders related to DM/PM were responsible for death in 2 cases. Conclusion. There are no specific clinical or biological features in paraneoplastic DM. In our series, breast neoplasm represented the first cancer associated with DM. Cancers of nasopharynx, colon and urinary tract had the second position. |
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| issn | 2501-062X |
| language | English |
| last_indexed | 2024-04-13T04:08:31Z |
| publishDate | 2018-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Romanian Journal of Internal Medicine |
| spelling | doaj.art-18ffc4851a5d48c1ad31c13e786d0e7c2022-12-22T03:03:10ZengSciendoRomanian Journal of Internal Medicine2501-062X2018-12-0156424324910.2478/rjim-2018-0015rjim-2018-0015Malignancy in a retrospective cohort of 17 patients with Dermatomyositis or Polymyositis in southern TunisiaSellami Khadija0Mseddi Madiha1Snoussi Mouna2Gharbi Hela3Frikha Faten4Salah Rayda Ben5Jallouli Moez6Marzouk Sameh7Masmoudi Abderrahmen8Bahloul Zouhir9Turki Hamida10Dermatology Department, Hedi Chaker University Hospital,Sfax, TunisiaDermatology Department, Hedi Chaker University Hospital,Sfax, TunisiaInternal Medicine Department, Hedi Chaker University Hospital,Sfax, TunisiaDermatology Department, Hedi Chaker University Hospital,Sfax, TunisiaInternal Medicine Department, Hedi Chaker University Hospital,Sfax, TunisiaInternal Medicine Department, Hedi Chaker University Hospital,Sfax, TunisiaInternal Medicine Department, Hedi Chaker University Hospital,Sfax, TunisiaInternal Medicine Department, Hedi Chaker University Hospital,Sfax, TunisiaDermatology Department, Hedi Chaker University Hospital,Sfax, TunisiaInternal Medicine Department, Hedi Chaker University Hospital,Sfax, TunisiaDermatology Department, Hedi Chaker University Hospital,Sfax, TunisiaIntroduction. The prognosis of dermatomyositis (DM)/ polymyositis (PM) in adults is partly related to their association with neoplasia. The aim of our study was to report the epidemiologic, clinical, paraclinical, therapeutic and evolutionary aspects of DM associated with malignancy in patients from Sfax, south eastern of Tunisia. Methods. A retrospective cohort study of patients with DM or PM admitted in Dermatology and Internal Medicine Departments of Hedi Chaker University Hospital of Sfax between 1996 and 2015. Cases of DM or PM associated with malignancy were retained. Results. Seventeen cases (13.5%) of DM or PM associated with malignancy were noted. Fourteen patients had DM and 3 patients had PM. The Sex ratio M / F was 0.3 and the mean age at diagnosis was 56.5 years. In DM patients, malignancy preceded the myositis in 64.2% of cases. In PM patients, only one patient was known to have breast cancer and the myositis revealed the cancer for 2 others. Treatment consisted of corticosteroids associated with methotrexate in 4 cases. Outcome was fatal in 5 cases (29.4%), due to the underlying cancer in 3 cases. Swallowing disorders related to DM/PM were responsible for death in 2 cases. Conclusion. There are no specific clinical or biological features in paraneoplastic DM. In our series, breast neoplasm represented the first cancer associated with DM. Cancers of nasopharynx, colon and urinary tract had the second position.https://doi.org/10.2478/rjim-2018-0015dermatomyositispolymyositiscancerparaneoplastic syndromerisk |
| spellingShingle | Sellami Khadija Mseddi Madiha Snoussi Mouna Gharbi Hela Frikha Faten Salah Rayda Ben Jallouli Moez Marzouk Sameh Masmoudi Abderrahmen Bahloul Zouhir Turki Hamida Malignancy in a retrospective cohort of 17 patients with Dermatomyositis or Polymyositis in southern Tunisia Romanian Journal of Internal Medicine dermatomyositis polymyositis cancer paraneoplastic syndrome risk |
| title | Malignancy in a retrospective cohort of 17 patients with Dermatomyositis or Polymyositis in southern Tunisia |
| title_full | Malignancy in a retrospective cohort of 17 patients with Dermatomyositis or Polymyositis in southern Tunisia |
| title_fullStr | Malignancy in a retrospective cohort of 17 patients with Dermatomyositis or Polymyositis in southern Tunisia |
| title_full_unstemmed | Malignancy in a retrospective cohort of 17 patients with Dermatomyositis or Polymyositis in southern Tunisia |
| title_short | Malignancy in a retrospective cohort of 17 patients with Dermatomyositis or Polymyositis in southern Tunisia |
| title_sort | malignancy in a retrospective cohort of 17 patients with dermatomyositis or polymyositis in southern tunisia |
| topic | dermatomyositis polymyositis cancer paraneoplastic syndrome risk |
| url | https://doi.org/10.2478/rjim-2018-0015 |
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