The Emerging Role of Hepatocellular eNOS in Non-alcoholic Fatty Liver Disease Development
Non-alcoholic fatty liver disease (NAFLD) is comprised of a spectrum of liver injury ranging from excess fat accumulation in the liver (steatosis), to steatohepatitis (NASH), to its end stage of cirrhosis. A hallmark of NAFLD progression is the decline in function of hepatic mitochondria, although t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00767/full |
| _version_ | 1818081208636014592 |
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| author | Rory P. Cunningham Rory P. Cunningham Ryan D. Sheldon R. Scott Rector R. Scott Rector R. Scott Rector |
| author_facet | Rory P. Cunningham Rory P. Cunningham Ryan D. Sheldon R. Scott Rector R. Scott Rector R. Scott Rector |
| author_sort | Rory P. Cunningham |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is comprised of a spectrum of liver injury ranging from excess fat accumulation in the liver (steatosis), to steatohepatitis (NASH), to its end stage of cirrhosis. A hallmark of NAFLD progression is the decline in function of hepatic mitochondria, although the mechanisms remain unresolved. Given the important role endothelial nitric oxide synthase (eNOS) plays in mitochondrial dynamics in other tissues, it has emerged as a potential mediator of maintaining mitochondrial function in the liver. In this mini review, we summarize the most relevant findings that extends current understanding of eNOS as a regulator of mitochondrial biogenesis, and identifies a potential additional role in mitochondrial turnover and attenuating inflammation during NAFLD development and progression. |
| first_indexed | 2024-12-10T19:02:33Z |
| format | Article |
| id | doaj.art-18ffd9a2db0a411ebf6cd936ef3b03c3 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-10T19:02:33Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-18ffd9a2db0a411ebf6cd936ef3b03c32022-12-22T01:36:57ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-07-011110.3389/fphys.2020.00767534770The Emerging Role of Hepatocellular eNOS in Non-alcoholic Fatty Liver Disease DevelopmentRory P. Cunningham0Rory P. Cunningham1Ryan D. Sheldon2R. Scott Rector3R. Scott Rector4R. Scott Rector5Research Service, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO, United StatesDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, United StatesMetabolic and Nutritional Programming, Center for Cancer and Cell Biology, Van Andel Institute, Grand Rapids, MI, United StatesResearch Service, Harry S. Truman Memorial Veterans’ Hospital, Columbia, MO, United StatesDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, United StatesMedicine-Division of Gastroenterology and Hepatology, University of Missouri, Columbia, MO, United StatesNon-alcoholic fatty liver disease (NAFLD) is comprised of a spectrum of liver injury ranging from excess fat accumulation in the liver (steatosis), to steatohepatitis (NASH), to its end stage of cirrhosis. A hallmark of NAFLD progression is the decline in function of hepatic mitochondria, although the mechanisms remain unresolved. Given the important role endothelial nitric oxide synthase (eNOS) plays in mitochondrial dynamics in other tissues, it has emerged as a potential mediator of maintaining mitochondrial function in the liver. In this mini review, we summarize the most relevant findings that extends current understanding of eNOS as a regulator of mitochondrial biogenesis, and identifies a potential additional role in mitochondrial turnover and attenuating inflammation during NAFLD development and progression.https://www.frontiersin.org/article/10.3389/fphys.2020.00767/fulleNOSnitric oxidemitochondriaNAFLDNASH |
| spellingShingle | Rory P. Cunningham Rory P. Cunningham Ryan D. Sheldon R. Scott Rector R. Scott Rector R. Scott Rector The Emerging Role of Hepatocellular eNOS in Non-alcoholic Fatty Liver Disease Development Frontiers in Physiology eNOS nitric oxide mitochondria NAFLD NASH |
| title | The Emerging Role of Hepatocellular eNOS in Non-alcoholic Fatty Liver Disease Development |
| title_full | The Emerging Role of Hepatocellular eNOS in Non-alcoholic Fatty Liver Disease Development |
| title_fullStr | The Emerging Role of Hepatocellular eNOS in Non-alcoholic Fatty Liver Disease Development |
| title_full_unstemmed | The Emerging Role of Hepatocellular eNOS in Non-alcoholic Fatty Liver Disease Development |
| title_short | The Emerging Role of Hepatocellular eNOS in Non-alcoholic Fatty Liver Disease Development |
| title_sort | emerging role of hepatocellular enos in non alcoholic fatty liver disease development |
| topic | eNOS nitric oxide mitochondria NAFLD NASH |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00767/full |
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