Clinical features of progressive supranuclear palsy
BackgroundProgressive supranuclear palsy (PSP) is a clinically heterogenous atypical parkinsonian syndrome. Therefore, early recognition and correct diagnosis of PSP is challenging but essential. This study aims to characterize the clinical manifestations, magnetic resonance imaging (MRI), and longi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1229491/full |
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| author | Yafei Wen Qijie Yang Bin Jiao Bin Jiao Bin Jiao Bin Jiao Bin Jiao Weiwei Zhang Jingyi Lin Yuan Zhu Qian Xu Qian Xu Hui Zhou Ling Weng Ling Weng Xinxin Liao Yafang Zhou Junling Wang Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Xinxiang Yan Xinxiang Yan Xinxiang Yan Xinxiang Yan Hong Jiang Beisha Tang Beisha Tang Beisha Tang Beisha Tang Lu Shen Lu Shen Lu Shen Lu Shen Lu Shen Lu Shen |
| author_facet | Yafei Wen Qijie Yang Bin Jiao Bin Jiao Bin Jiao Bin Jiao Bin Jiao Weiwei Zhang Jingyi Lin Yuan Zhu Qian Xu Qian Xu Hui Zhou Ling Weng Ling Weng Xinxin Liao Yafang Zhou Junling Wang Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Xinxiang Yan Xinxiang Yan Xinxiang Yan Xinxiang Yan Hong Jiang Beisha Tang Beisha Tang Beisha Tang Beisha Tang Lu Shen Lu Shen Lu Shen Lu Shen Lu Shen Lu Shen |
| author_sort | Yafei Wen |
| collection | DOAJ |
| description | BackgroundProgressive supranuclear palsy (PSP) is a clinically heterogenous atypical parkinsonian syndrome. Therefore, early recognition and correct diagnosis of PSP is challenging but essential. This study aims to characterize the clinical manifestations, magnetic resonance imaging (MRI), and longitudinal MRI changes of PSP in China.MethodClinical and MRI presentations were compared among 150 cases with PSP. Then the longitudinal MRI changes among 20 patients with PSP were further explored. Additionally, a series of midbrain-based MRI parameters was compared between PSP-P and PD.ResultsThroughout the course of the disease, there were differences in the symptoms of the fall and hand tremor between the PSP-RS and PSP-P. There were significant differences in the six midbrain-based MRI parameters between the PSP-RS and the PSP-P, including hummingbird sign, midbrain diameter, midbrain to pons ratio (MTPR), midbrain area, midbrain area to pons area ratio (Ma/Pa), and midbrain tegmental length (MBTegm). Longitudinal MRI studies revealed that the annual rel.ΔMTPR and rel.Δ (Ma/Pa) for PSP were 5.55 and 6.52%, respectively; additionally, PSP-RS presented a higher decline rate than PSP-P. Moreover, MTPR ≤0.56, midbrain diameter ≤ 0.92, midbrain area ≤ 1.00, and third ventricle width ≤ 0.75 could identify PSP-P from PD.ConclusionPSP-P differs from PSP-RS regarding clinical manifestations, MRI, and longitudinal MRI changes. MRI parameters could be potential imaging markers to identify PSP-P from PD. |
| first_indexed | 2024-03-12T11:54:57Z |
| format | Article |
| id | doaj.art-1902f4e89ff04d718370cf8339183a04 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-12T11:54:57Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-1902f4e89ff04d718370cf8339183a042023-08-31T04:53:00ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-08-011510.3389/fnagi.2023.12294911229491Clinical features of progressive supranuclear palsyYafei Wen0Qijie Yang1Bin Jiao2Bin Jiao3Bin Jiao4Bin Jiao5Bin Jiao6Weiwei Zhang7Jingyi Lin8Yuan Zhu9Qian Xu10Qian Xu11Hui Zhou12Ling Weng13Ling Weng14Xinxin Liao15Yafang Zhou16Junling Wang17Jifeng Guo18Jifeng Guo19Jifeng Guo20Jifeng Guo21Xinxiang Yan22Xinxiang Yan23Xinxiang Yan24Xinxiang Yan25Hong Jiang26Beisha Tang27Beisha Tang28Beisha Tang29Beisha Tang30Lu Shen31Lu Shen32Lu Shen33Lu Shen34Lu Shen35Lu Shen36Department of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Central South University, Changsha, ChinaEngineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, ChinaHunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, ChinaDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, ChinaEngineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Central South University, Changsha, ChinaDepartment of Geriatrics Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Geriatrics Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Central South University, Changsha, ChinaHunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Central South University, Changsha, ChinaHunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Central South University, Changsha, ChinaHunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Central South University, Changsha, ChinaEngineering Research Center of Hunan Province in Cognitive Impairment Disorders, Central South University, Changsha, ChinaHunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, ChinaKey Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, ChinaKey Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Changsha, ChinaBackgroundProgressive supranuclear palsy (PSP) is a clinically heterogenous atypical parkinsonian syndrome. Therefore, early recognition and correct diagnosis of PSP is challenging but essential. This study aims to characterize the clinical manifestations, magnetic resonance imaging (MRI), and longitudinal MRI changes of PSP in China.MethodClinical and MRI presentations were compared among 150 cases with PSP. Then the longitudinal MRI changes among 20 patients with PSP were further explored. Additionally, a series of midbrain-based MRI parameters was compared between PSP-P and PD.ResultsThroughout the course of the disease, there were differences in the symptoms of the fall and hand tremor between the PSP-RS and PSP-P. There were significant differences in the six midbrain-based MRI parameters between the PSP-RS and the PSP-P, including hummingbird sign, midbrain diameter, midbrain to pons ratio (MTPR), midbrain area, midbrain area to pons area ratio (Ma/Pa), and midbrain tegmental length (MBTegm). Longitudinal MRI studies revealed that the annual rel.ΔMTPR and rel.Δ (Ma/Pa) for PSP were 5.55 and 6.52%, respectively; additionally, PSP-RS presented a higher decline rate than PSP-P. Moreover, MTPR ≤0.56, midbrain diameter ≤ 0.92, midbrain area ≤ 1.00, and third ventricle width ≤ 0.75 could identify PSP-P from PD.ConclusionPSP-P differs from PSP-RS regarding clinical manifestations, MRI, and longitudinal MRI changes. MRI parameters could be potential imaging markers to identify PSP-P from PD.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1229491/fullprogressive supranuclear palsyphenotypeRichardson’s syndromeparkinsonismlongitudinal MRI |
| spellingShingle | Yafei Wen Qijie Yang Bin Jiao Bin Jiao Bin Jiao Bin Jiao Bin Jiao Weiwei Zhang Jingyi Lin Yuan Zhu Qian Xu Qian Xu Hui Zhou Ling Weng Ling Weng Xinxin Liao Yafang Zhou Junling Wang Jifeng Guo Jifeng Guo Jifeng Guo Jifeng Guo Xinxiang Yan Xinxiang Yan Xinxiang Yan Xinxiang Yan Hong Jiang Beisha Tang Beisha Tang Beisha Tang Beisha Tang Lu Shen Lu Shen Lu Shen Lu Shen Lu Shen Lu Shen Clinical features of progressive supranuclear palsy Frontiers in Aging Neuroscience progressive supranuclear palsy phenotype Richardson’s syndrome parkinsonism longitudinal MRI |
| title | Clinical features of progressive supranuclear palsy |
| title_full | Clinical features of progressive supranuclear palsy |
| title_fullStr | Clinical features of progressive supranuclear palsy |
| title_full_unstemmed | Clinical features of progressive supranuclear palsy |
| title_short | Clinical features of progressive supranuclear palsy |
| title_sort | clinical features of progressive supranuclear palsy |
| topic | progressive supranuclear palsy phenotype Richardson’s syndrome parkinsonism longitudinal MRI |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1229491/full |
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