Modifier genes and the plasticity of genetic networks in mice.
Modifier genes are an integral part of the genetic landscape in both humans and experimental organisms, but have been less well explored in mammals than other systems. A growing number of modifier genes in mouse models of disease nonetheless illustrate the potential for novel findings, while new tec...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3325199?pdf=render |
| _version_ | 1819088698671628288 |
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| author | Bruce A Hamilton Benjamin D Yu |
| author_facet | Bruce A Hamilton Benjamin D Yu |
| author_sort | Bruce A Hamilton |
| collection | DOAJ |
| description | Modifier genes are an integral part of the genetic landscape in both humans and experimental organisms, but have been less well explored in mammals than other systems. A growing number of modifier genes in mouse models of disease nonetheless illustrate the potential for novel findings, while new technical advances promise many more to come. Modifier genes in mouse models include induced mutations and spontaneous or wild-derived variations captured in inbred strains. Identification of modifiers among wild-derived variants in particular should detect disease modifiers that have been shaped by selection and might therefore be compatible with high fitness and function. Here we review selected examples and argue that modifier genes derived from natural variation may provide a bias for nodes in genetic networks that have greater intrinsic plasticity and whose therapeutic manipulation may therefore be more resilient to side effects than conventional targets. |
| first_indexed | 2024-12-21T21:56:11Z |
| format | Article |
| id | doaj.art-19036e197e8e4fab91836d6721f108c0 |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-12-21T21:56:11Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-19036e197e8e4fab91836d6721f108c02022-12-21T18:48:57ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042012-01-0184e100264410.1371/journal.pgen.1002644Modifier genes and the plasticity of genetic networks in mice.Bruce A HamiltonBenjamin D YuModifier genes are an integral part of the genetic landscape in both humans and experimental organisms, but have been less well explored in mammals than other systems. A growing number of modifier genes in mouse models of disease nonetheless illustrate the potential for novel findings, while new technical advances promise many more to come. Modifier genes in mouse models include induced mutations and spontaneous or wild-derived variations captured in inbred strains. Identification of modifiers among wild-derived variants in particular should detect disease modifiers that have been shaped by selection and might therefore be compatible with high fitness and function. Here we review selected examples and argue that modifier genes derived from natural variation may provide a bias for nodes in genetic networks that have greater intrinsic plasticity and whose therapeutic manipulation may therefore be more resilient to side effects than conventional targets.http://europepmc.org/articles/PMC3325199?pdf=render |
| spellingShingle | Bruce A Hamilton Benjamin D Yu Modifier genes and the plasticity of genetic networks in mice. PLoS Genetics |
| title | Modifier genes and the plasticity of genetic networks in mice. |
| title_full | Modifier genes and the plasticity of genetic networks in mice. |
| title_fullStr | Modifier genes and the plasticity of genetic networks in mice. |
| title_full_unstemmed | Modifier genes and the plasticity of genetic networks in mice. |
| title_short | Modifier genes and the plasticity of genetic networks in mice. |
| title_sort | modifier genes and the plasticity of genetic networks in mice |
| url | http://europepmc.org/articles/PMC3325199?pdf=render |
| work_keys_str_mv | AT bruceahamilton modifiergenesandtheplasticityofgeneticnetworksinmice AT benjamindyu modifiergenesandtheplasticityofgeneticnetworksinmice |