Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei

Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei

Protein kinases are potentially attractive therapeutic targets for neglected parasitic diseases, including African trypanosomiasis caused by the protozoan, Trypanosoma brucei. How to prioritize T. brucei kinases and quantify their intracellular engagement by small-molecule inhibitors remain unsolved...

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Bibliographic Details
Main Authors: Mari Nishino, Jonathan W Choy, Nathan N Gushwa, Juan A Oses-Prieto, Kyriacos Koupparis, Alma L Burlingame, Adam R Renslo, James H McKerrow, Jack Taunton
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-07-01
Series:eLife
Subjects:
T. brucei
chemoproteomics
hypothemycin
protein kinase
Online Access:https://elifesciences.org/articles/00712

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