A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity
A growing number of cargo-specific effector proteins are being identified that interact with both dynein and dynactin and form processive dynein-dynactin-effector complexes. Here the authors identify and characterize a conserved mechanism of interaction between dynein and unrelated effector proteins...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03412-8 |
| _version_ | 1818994781032808448 |
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| author | In-Gyun Lee Mara A. Olenick Malgorzata Boczkowska Clara Franzini-Armstrong Erika L. F. Holzbaur Roberto Dominguez |
| author_facet | In-Gyun Lee Mara A. Olenick Malgorzata Boczkowska Clara Franzini-Armstrong Erika L. F. Holzbaur Roberto Dominguez |
| author_sort | In-Gyun Lee |
| collection | DOAJ |
| description | A growing number of cargo-specific effector proteins are being identified that interact with both dynein and dynactin and form processive dynein-dynactin-effector complexes. Here the authors identify and characterize a conserved mechanism of interaction between dynein and unrelated effector proteins. |
| first_indexed | 2024-12-20T21:03:24Z |
| format | Article |
| id | doaj.art-1906ae3d8b11421f880a7d0604e616ad |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:03:24Z |
| publishDate | 2018-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1906ae3d8b11421f880a7d0604e616ad2022-12-21T19:26:40ZengNature PortfolioNature Communications2041-17232018-03-019111210.1038/s41467-018-03412-8A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivityIn-Gyun Lee0Mara A. Olenick1Malgorzata Boczkowska2Clara Franzini-Armstrong3Erika L. F. Holzbaur4Roberto Dominguez5Department of Physiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Physiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Physiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Cell and Developmental Biology, University of PennsylvaniaDepartment of Physiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Physiology, Perelman School of Medicine, University of PennsylvaniaA growing number of cargo-specific effector proteins are being identified that interact with both dynein and dynactin and form processive dynein-dynactin-effector complexes. Here the authors identify and characterize a conserved mechanism of interaction between dynein and unrelated effector proteins.https://doi.org/10.1038/s41467-018-03412-8 |
| spellingShingle | In-Gyun Lee Mara A. Olenick Malgorzata Boczkowska Clara Franzini-Armstrong Erika L. F. Holzbaur Roberto Dominguez A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity Nature Communications |
| title | A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity |
| title_full | A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity |
| title_fullStr | A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity |
| title_full_unstemmed | A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity |
| title_short | A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity |
| title_sort | conserved interaction of the dynein light intermediate chain with dynein dynactin effectors necessary for processivity |
| url | https://doi.org/10.1038/s41467-018-03412-8 |
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