In-vivo bone remodeling potential of Sr-d-Ca-P /PLLA-HAp coated biodegradable ZK60 alloy bone plate
Magnesium and its alloys are widely applied biomaterials due to their biodegradability and biocompatibility. However, rapid degradation and hydrogen gas evolution hinder its applicability on a commercial scale. In this study, we developed an Mg alloy bone plate for bone remodeling and support after...
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Elsevier
2023-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422003313 |
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| author | Seong-Su Park Ume Farwa Ihho Park Byoung-Gi Moon Soo-Bin Im Byong-Taek Lee |
| author_facet | Seong-Su Park Ume Farwa Ihho Park Byoung-Gi Moon Soo-Bin Im Byong-Taek Lee |
| author_sort | Seong-Su Park |
| collection | DOAJ |
| description | Magnesium and its alloys are widely applied biomaterials due to their biodegradability and biocompatibility. However, rapid degradation and hydrogen gas evolution hinder its applicability on a commercial scale. In this study, we developed an Mg alloy bone plate for bone remodeling and support after a fracture. We further coated the Mg alloy plate with Sr-D-Ca-P (Sr dopped Ca–P coating) and Sr-D-Ca-P/PLLA-HAp to evaluate and compare their biodegradability and biocompatibility in both in vitro and in vivo experiments. Chemical immersion and dip coating were employed for the formation of Sr-D-Ca-P and PLLA-HAp layers, respectively. In vitro evaluation depicted that both coatings delayed the degradation process and exhibited excellent biocompatibility. MC3T3-E1cells proliferation and osteogenic markers expression were also promoted. In vivo results showed that both Sr-D-Ca-P and Sr-D-Ca-P/PLLA-HAp coated bone plates had slower degradation rate as compared to Mg alloy. Remarkable bone remodeling was observed around the Sr-D-Ca-P/PLLA-HAp coated bone plate than bare Mg alloy and Sr-D-Ca-P coated bone plate. These results suggest that Sr-D-Ca-P/PLLA-HAp coated Mg alloy bone plate with lower degradation and enhanced biocompatibility can be applied as an orthopedic implant. |
| first_indexed | 2024-04-10T18:54:18Z |
| format | Article |
| id | doaj.art-190855af405b44debe04b067309fe1e8 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-10T18:54:18Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-190855af405b44debe04b067309fe1e82023-02-01T04:27:25ZengElsevierMaterials Today Bio2590-00642023-02-0118100533In-vivo bone remodeling potential of Sr-d-Ca-P /PLLA-HAp coated biodegradable ZK60 alloy bone plateSeong-Su Park0Ume Farwa1Ihho Park2Byoung-Gi Moon3Soo-Bin Im4Byong-Taek Lee5Department of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan, South KoreaInstitute of Tissue Regeneration, Soonchunhyang University, Cheonan, South KoreaKorea Institute of Material Science, Changwon, South KoreaKorea Institute of Material Science, Changwon, South KoreaInstitute of Tissue Regeneration, Soonchunhyang University, Cheonan, South Korea; Department of Neuro-surgery, Soonchunhyang University Medical Centre, Bucheon, South KoreaDepartment of Regenerative Medicine, College of Medicine, Soonchunhyang University, Cheonan, South Korea; Institute of Tissue Regeneration, Soonchunhyang University, Cheonan, South Korea; Corresponding author. Department of regenerative medicine, College of Medicine, Soonchunhyang University, Cheonan, South Korea.Magnesium and its alloys are widely applied biomaterials due to their biodegradability and biocompatibility. However, rapid degradation and hydrogen gas evolution hinder its applicability on a commercial scale. In this study, we developed an Mg alloy bone plate for bone remodeling and support after a fracture. We further coated the Mg alloy plate with Sr-D-Ca-P (Sr dopped Ca–P coating) and Sr-D-Ca-P/PLLA-HAp to evaluate and compare their biodegradability and biocompatibility in both in vitro and in vivo experiments. Chemical immersion and dip coating were employed for the formation of Sr-D-Ca-P and PLLA-HAp layers, respectively. In vitro evaluation depicted that both coatings delayed the degradation process and exhibited excellent biocompatibility. MC3T3-E1cells proliferation and osteogenic markers expression were also promoted. In vivo results showed that both Sr-D-Ca-P and Sr-D-Ca-P/PLLA-HAp coated bone plates had slower degradation rate as compared to Mg alloy. Remarkable bone remodeling was observed around the Sr-D-Ca-P/PLLA-HAp coated bone plate than bare Mg alloy and Sr-D-Ca-P coated bone plate. These results suggest that Sr-D-Ca-P/PLLA-HAp coated Mg alloy bone plate with lower degradation and enhanced biocompatibility can be applied as an orthopedic implant.http://www.sciencedirect.com/science/article/pii/S2590006422003313Magnesium alloyBone plateSr-D-Ca-P/PLLA-HAp coatingBone remodelingCorrosion resistance |
| spellingShingle | Seong-Su Park Ume Farwa Ihho Park Byoung-Gi Moon Soo-Bin Im Byong-Taek Lee In-vivo bone remodeling potential of Sr-d-Ca-P /PLLA-HAp coated biodegradable ZK60 alloy bone plate Materials Today Bio Magnesium alloy Bone plate Sr-D-Ca-P/PLLA-HAp coating Bone remodeling Corrosion resistance |
| title | In-vivo bone remodeling potential of Sr-d-Ca-P /PLLA-HAp coated biodegradable ZK60 alloy bone plate |
| title_full | In-vivo bone remodeling potential of Sr-d-Ca-P /PLLA-HAp coated biodegradable ZK60 alloy bone plate |
| title_fullStr | In-vivo bone remodeling potential of Sr-d-Ca-P /PLLA-HAp coated biodegradable ZK60 alloy bone plate |
| title_full_unstemmed | In-vivo bone remodeling potential of Sr-d-Ca-P /PLLA-HAp coated biodegradable ZK60 alloy bone plate |
| title_short | In-vivo bone remodeling potential of Sr-d-Ca-P /PLLA-HAp coated biodegradable ZK60 alloy bone plate |
| title_sort | in vivo bone remodeling potential of sr d ca p plla hap coated biodegradable zk60 alloy bone plate |
| topic | Magnesium alloy Bone plate Sr-D-Ca-P/PLLA-HAp coating Bone remodeling Corrosion resistance |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422003313 |
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