Identification of new benzimidazole-triazole hybrids as anticancer agents: multi-target recognition, in vitro and in silico studies

Identification of new benzimidazole-triazole hybrids as anticancer agents: multi-target recognition, in vitro and in silico studies

AbstractMulti-target inhibitors represent useful anticancer agents with superior therapeutic attributes. Here in, two novel series of benzimidazole-triazole hybrids were designed, synthesised as multi-target EGFR, VEGFR-2 and Topo II inhibitors, and evaluated for anticancer activity. Compounds 5a an...

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Bibliographic Details
Main Authors:	Dina I. A. Othman, Abdelrahman Hamdi, Samar S. Tawfik, Abdullah A. Elgazar, Amany S. Mostafa
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	Benzimidazole 123-triazole hybrids anticancer EGFR VEGFR-2 Topo II
Online Access:	https://www.tandfonline.com/doi/10.1080/14756366.2023.2166037

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