Compilation of the Antimicrobial Compounds Produced by <i>Burkholderia</i> Sensu Stricto
Due to the increase in multidrug-resistant microorganisms, the investigation of novel or more efficient antimicrobial compounds is essential. The World Health Organization issued a list of priority multidrug-resistant bacteria whose eradication will require new antibiotics. Among them, <i>Acin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/4/1646 |
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| author | Mariana Rodríguez-Cisneros Leslie Mariana Morales-Ruíz Anuar Salazar-Gómez Fernando Uriel Rojas-Rojas Paulina Estrada-de los Santos |
| author_facet | Mariana Rodríguez-Cisneros Leslie Mariana Morales-Ruíz Anuar Salazar-Gómez Fernando Uriel Rojas-Rojas Paulina Estrada-de los Santos |
| author_sort | Mariana Rodríguez-Cisneros |
| collection | DOAJ |
| description | Due to the increase in multidrug-resistant microorganisms, the investigation of novel or more efficient antimicrobial compounds is essential. The World Health Organization issued a list of priority multidrug-resistant bacteria whose eradication will require new antibiotics. Among them, <i>Acinetobacter baumannii, Pseudomonas aeruginosa</i>, and Enterobacteriaceae are in the “critical” (most urgent) category. As a result, major investigations are ongoing worldwide to discover new antimicrobial compounds. <i>Burkholderia</i>, specifically <i>Burkholderia</i> sensu stricto, is recognized as an antimicrobial-producing group of species. Highly dissimilar compounds are among the molecules produced by this genus, such as those that are unique to a particular strain (like compound CF66I produced by <i>Burkholderia cepacia</i> CF-66) or antimicrobials found in a number of species, e.g., phenazines or ornibactins. The compounds produced by <i>Burkholderia</i> include N-containing heterocycles, volatile organic compounds, polyenes, polyynes, siderophores, macrolides, bacteriocins, quinolones, and other not classified antimicrobials. Some of them might be candidates not only for antimicrobials for both bacteria and fungi, but also as anticancer or antitumor agents. Therefore, in this review, the wide range of antimicrobial compounds produced by <i>Burkholderia</i> is explored, focusing especially on those compounds that were tested in vitro for antimicrobial activity. In addition, information was gathered regarding novel compounds discovered by genome-guided approaches. |
| first_indexed | 2024-03-11T08:21:48Z |
| format | Article |
| id | doaj.art-19096f4149e94014a4d8096750c73115 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T08:21:48Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-19096f4149e94014a4d8096750c731152023-11-16T22:21:19ZengMDPI AGMolecules1420-30492023-02-01284164610.3390/molecules28041646Compilation of the Antimicrobial Compounds Produced by <i>Burkholderia</i> Sensu StrictoMariana Rodríguez-Cisneros0Leslie Mariana Morales-Ruíz1Anuar Salazar-Gómez2Fernando Uriel Rojas-Rojas3Paulina Estrada-de los Santos4Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. de Carpio y Plan de Ayala S/N Col. Santo Tomás Alc. Miguel Hidalgo, Ciudad de México 11340, MexicoDepartamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. de Carpio y Plan de Ayala S/N Col. Santo Tomás Alc. Miguel Hidalgo, Ciudad de México 11340, MexicoEscuela Nacional de Estudios Superiores Unidad León, Universidad Nacional Autónoma de México (ENES-León UNAM), Blvd. UNAM 2011, León, Guanajuato 37684, MexicoLaboratorio de Ciencias AgroGenómicas, Escuela Nacional de Estudios Superiores Unidad León, Universidad Nacional Autónoma de México (ENES-León UNAM), Blvd. UNAM 2011, León, Guanajuato 37684, MexicoDepartamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prol. de Carpio y Plan de Ayala S/N Col. Santo Tomás Alc. Miguel Hidalgo, Ciudad de México 11340, MexicoDue to the increase in multidrug-resistant microorganisms, the investigation of novel or more efficient antimicrobial compounds is essential. The World Health Organization issued a list of priority multidrug-resistant bacteria whose eradication will require new antibiotics. Among them, <i>Acinetobacter baumannii, Pseudomonas aeruginosa</i>, and Enterobacteriaceae are in the “critical” (most urgent) category. As a result, major investigations are ongoing worldwide to discover new antimicrobial compounds. <i>Burkholderia</i>, specifically <i>Burkholderia</i> sensu stricto, is recognized as an antimicrobial-producing group of species. Highly dissimilar compounds are among the molecules produced by this genus, such as those that are unique to a particular strain (like compound CF66I produced by <i>Burkholderia cepacia</i> CF-66) or antimicrobials found in a number of species, e.g., phenazines or ornibactins. The compounds produced by <i>Burkholderia</i> include N-containing heterocycles, volatile organic compounds, polyenes, polyynes, siderophores, macrolides, bacteriocins, quinolones, and other not classified antimicrobials. Some of them might be candidates not only for antimicrobials for both bacteria and fungi, but also as anticancer or antitumor agents. Therefore, in this review, the wide range of antimicrobial compounds produced by <i>Burkholderia</i> is explored, focusing especially on those compounds that were tested in vitro for antimicrobial activity. In addition, information was gathered regarding novel compounds discovered by genome-guided approaches.https://www.mdpi.com/1420-3049/28/4/1646<i>Burkholderia</i> sensu strictoantimicrobialsnon-ribosomal peptides |
| spellingShingle | Mariana Rodríguez-Cisneros Leslie Mariana Morales-Ruíz Anuar Salazar-Gómez Fernando Uriel Rojas-Rojas Paulina Estrada-de los Santos Compilation of the Antimicrobial Compounds Produced by <i>Burkholderia</i> Sensu Stricto Molecules <i>Burkholderia</i> sensu stricto antimicrobials non-ribosomal peptides |
| title | Compilation of the Antimicrobial Compounds Produced by <i>Burkholderia</i> Sensu Stricto |
| title_full | Compilation of the Antimicrobial Compounds Produced by <i>Burkholderia</i> Sensu Stricto |
| title_fullStr | Compilation of the Antimicrobial Compounds Produced by <i>Burkholderia</i> Sensu Stricto |
| title_full_unstemmed | Compilation of the Antimicrobial Compounds Produced by <i>Burkholderia</i> Sensu Stricto |
| title_short | Compilation of the Antimicrobial Compounds Produced by <i>Burkholderia</i> Sensu Stricto |
| title_sort | compilation of the antimicrobial compounds produced by i burkholderia i sensu stricto |
| topic | <i>Burkholderia</i> sensu stricto antimicrobials non-ribosomal peptides |
| url | https://www.mdpi.com/1420-3049/28/4/1646 |
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