Effects of vitamin D3 (cholecalciferol) supplementation on systemic lupus erythematosus patients with hypovitaminosis D on serum pro-inflammatory cytokines (IL-6, IL-7, IFN-Gamma), anti-inflammatory cytokine (TGF-Beta) and anti-ds DNA levels
A B S T R A C T Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease and can attack almost all organs and tissues of the human body. Beside genetic factors, environmental factors are thought to play a role, such as ultraviolet light, viral infections and smoking, causing a bre...
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| Format: | Article |
| Language: | English |
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Indonesia Rheumatology Association
2021-02-01
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| Series: | Indonesian Journal of Rheumatology |
| Online Access: | https://journalrheumatology.or.id/index.php/ijr/article/view/150 |
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| author | Cesarius Singgih Wahono Irene Saveria Cameleia Diah Setyorini Zoraida Dwi Wahyuni Handono Kalim Kusworini Handono |
| author_facet | Cesarius Singgih Wahono Irene Saveria Cameleia Diah Setyorini Zoraida Dwi Wahyuni Handono Kalim Kusworini Handono |
| author_sort | Cesarius Singgih Wahono |
| collection | DOAJ |
| description | A B S T R A C T
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease
and can attack almost all organs and tissues of the human body. Beside genetic
factors, environmental factors are thought to play a role, such as ultraviolet light,
viral infections and smoking, causing a breakdown of self-tolerance which can
trigger an autoimmune response. The study was conducted in the outpatient and
inpatient units of the Rheumatology Division of the Department of Internal
Medicine Saiful Anwar General Hospital/Faculty of medicine Universitas
Brawijaya, Malang. Subjects were female patients, aged > 18 years who had been
diagnosed as SLE by internist-rheumatologist based on the 1997 ACR criteria, with
SLEDAI score > 3. After 3 months of supplementation, there was a significant
decrease in serum levels of the three pro-inflammatory cytokines (IL-6, IL-17, IFN-
gamma), as shown in table 3, compared to before treatment, as well as anti-dsDNA levels.
Serum TGF-beta1 levels increased significantly, while 25 (OH) D3 levels also increased
significantly. |
| first_indexed | 2024-12-22T19:19:08Z |
| format | Article |
| id | doaj.art-1909da1889bf4e4c8e7f9737a0265d43 |
| institution | Directory Open Access Journal |
| issn | 2086-1435 2581-1142 |
| language | English |
| last_indexed | 2024-12-22T19:19:08Z |
| publishDate | 2021-02-01 |
| publisher | Indonesia Rheumatology Association |
| record_format | Article |
| series | Indonesian Journal of Rheumatology |
| spelling | doaj.art-1909da1889bf4e4c8e7f9737a0265d432022-12-21T18:15:25ZengIndonesia Rheumatology AssociationIndonesian Journal of Rheumatology2086-14352581-11422021-02-0112230230810.37275/ijr.v12i2.150150Effects of vitamin D3 (cholecalciferol) supplementation on systemic lupus erythematosus patients with hypovitaminosis D on serum pro-inflammatory cytokines (IL-6, IL-7, IFN-Gamma), anti-inflammatory cytokine (TGF-Beta) and anti-ds DNA levelsCesarius Singgih Wahono0Irene Saveria1Cameleia Diah Setyorini2Zoraida Dwi Wahyuni3Handono Kalim4Kusworini Handono5Rheumatology division, Departement of Internal Medicine Faculty of Medicine Universitas Brawijaya/Saiful Anwar Hospital MalangRheumatology division, Departement of Internal Medicine Faculty of Medicine Universitas Brawijaya/Saiful Anwar Hospital MalangRheumatology division, Departement of Internal Medicine Faculty of Medicine Universitas Brawijaya/Saiful Anwar Hospital Malang Rheumatology division, Departement of Internal Medicine Faculty of Medicine Universitas Brawijaya/Saiful Anwar Hospital Malang Rheumatology division, Departement of Internal Medicine Faculty of Medicine Universitas Brawijaya/Saiful Anwar Hospital Malang Departement of Clinical Pathology, Faculty of Medicine Universitas Brawijaya/Saiful Anwar Hospital MalangA B S T R A C T Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease and can attack almost all organs and tissues of the human body. Beside genetic factors, environmental factors are thought to play a role, such as ultraviolet light, viral infections and smoking, causing a breakdown of self-tolerance which can trigger an autoimmune response. The study was conducted in the outpatient and inpatient units of the Rheumatology Division of the Department of Internal Medicine Saiful Anwar General Hospital/Faculty of medicine Universitas Brawijaya, Malang. Subjects were female patients, aged > 18 years who had been diagnosed as SLE by internist-rheumatologist based on the 1997 ACR criteria, with SLEDAI score > 3. After 3 months of supplementation, there was a significant decrease in serum levels of the three pro-inflammatory cytokines (IL-6, IL-17, IFN- gamma), as shown in table 3, compared to before treatment, as well as anti-dsDNA levels. Serum TGF-beta1 levels increased significantly, while 25 (OH) D3 levels also increased significantly.https://journalrheumatology.or.id/index.php/ijr/article/view/150 |
| spellingShingle | Cesarius Singgih Wahono Irene Saveria Cameleia Diah Setyorini Zoraida Dwi Wahyuni Handono Kalim Kusworini Handono Effects of vitamin D3 (cholecalciferol) supplementation on systemic lupus erythematosus patients with hypovitaminosis D on serum pro-inflammatory cytokines (IL-6, IL-7, IFN-Gamma), anti-inflammatory cytokine (TGF-Beta) and anti-ds DNA levels Indonesian Journal of Rheumatology |
| title | Effects of vitamin D3 (cholecalciferol) supplementation on systemic lupus erythematosus patients with hypovitaminosis D on serum pro-inflammatory cytokines (IL-6, IL-7, IFN-Gamma), anti-inflammatory cytokine (TGF-Beta) and anti-ds DNA levels |
| title_full | Effects of vitamin D3 (cholecalciferol) supplementation on systemic lupus erythematosus patients with hypovitaminosis D on serum pro-inflammatory cytokines (IL-6, IL-7, IFN-Gamma), anti-inflammatory cytokine (TGF-Beta) and anti-ds DNA levels |
| title_fullStr | Effects of vitamin D3 (cholecalciferol) supplementation on systemic lupus erythematosus patients with hypovitaminosis D on serum pro-inflammatory cytokines (IL-6, IL-7, IFN-Gamma), anti-inflammatory cytokine (TGF-Beta) and anti-ds DNA levels |
| title_full_unstemmed | Effects of vitamin D3 (cholecalciferol) supplementation on systemic lupus erythematosus patients with hypovitaminosis D on serum pro-inflammatory cytokines (IL-6, IL-7, IFN-Gamma), anti-inflammatory cytokine (TGF-Beta) and anti-ds DNA levels |
| title_short | Effects of vitamin D3 (cholecalciferol) supplementation on systemic lupus erythematosus patients with hypovitaminosis D on serum pro-inflammatory cytokines (IL-6, IL-7, IFN-Gamma), anti-inflammatory cytokine (TGF-Beta) and anti-ds DNA levels |
| title_sort | effects of vitamin d3 cholecalciferol supplementation on systemic lupus erythematosus patients with hypovitaminosis d on serum pro inflammatory cytokines il 6 il 7 ifn gamma anti inflammatory cytokine tgf beta and anti ds dna levels |
| url | https://journalrheumatology.or.id/index.php/ijr/article/view/150 |
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