Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase
Glimepiride is a third generation sulphonylurea antidiabetic drug. Glimepiride is poorly water soluble drug that may cause poor dissolution and unpredicted bioavailability. Self nanoemulsifying drug delivery systems (SNEDDS) have become a popular formulation option as nanocarriers for poorly water-s...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universitas Ahmad Dahlan
2017-12-01
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| Series: | Pharmaciana |
| Subjects: | |
| Online Access: | http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/7387/pdf_59 |
| _version_ | 1818876810569449472 |
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| author | Sani Ega Priani Nurrayyan Fitrianti Darusman |
| author_facet | Sani Ega Priani Nurrayyan Fitrianti Darusman |
| author_sort | Sani Ega Priani |
| collection | DOAJ |
| description | Glimepiride is a third generation sulphonylurea antidiabetic drug. Glimepiride is poorly water soluble drug that may cause poor dissolution and unpredicted bioavailability. Self nanoemulsifying drug delivery systems (SNEDDS) have become a popular formulation option as nanocarriers for poorly water-soluble drugs. The objective of this research was to develop SNEDDS formulation of glimepiride to improve oral dissolution and bioavailability. Glimepiride SNEDDS was formulated using oleic acid as oil phase, tween 80 as surfactant, and transcutol as co-surfactant due to their higher solubilization effect. The formulated SNEDDS were evaluated for % transmittance, dispersibility, thermodynamic stability, dissolution, globule size and morphology analysis. The results showed that the glimepiride SNEDDS was rapidly formed clear emulsion and stabile based on thermodynamic test. Transmission electron microscopy demonstrated the spherical droplets morphology in nanometer range. The globule average diameter size was 45 nm. The SNEDDS formulation significantly increase dissolution of glimepiride compared with pure drug. |
| first_indexed | 2024-12-19T13:48:18Z |
| format | Article |
| id | doaj.art-190a25d6f6584406944165837c41ef58 |
| institution | Directory Open Access Journal |
| issn | 2088-4559 2477-0256 |
| language | English |
| last_indexed | 2024-12-19T13:48:18Z |
| publishDate | 2017-12-01 |
| publisher | Universitas Ahmad Dahlan |
| record_format | Article |
| series | Pharmaciana |
| spelling | doaj.art-190a25d6f6584406944165837c41ef582022-12-21T20:18:49ZengUniversitas Ahmad DahlanPharmaciana2088-45592477-02562017-12-017226727610.12928/pharmaciana.v7i2.7387Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase Sani Ega Priani0Nurrayyan1Fitrianti Darusman2Prodi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Islam BandungProdi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Islam BandungProdi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Islam BandungGlimepiride is a third generation sulphonylurea antidiabetic drug. Glimepiride is poorly water soluble drug that may cause poor dissolution and unpredicted bioavailability. Self nanoemulsifying drug delivery systems (SNEDDS) have become a popular formulation option as nanocarriers for poorly water-soluble drugs. The objective of this research was to develop SNEDDS formulation of glimepiride to improve oral dissolution and bioavailability. Glimepiride SNEDDS was formulated using oleic acid as oil phase, tween 80 as surfactant, and transcutol as co-surfactant due to their higher solubilization effect. The formulated SNEDDS were evaluated for % transmittance, dispersibility, thermodynamic stability, dissolution, globule size and morphology analysis. The results showed that the glimepiride SNEDDS was rapidly formed clear emulsion and stabile based on thermodynamic test. Transmission electron microscopy demonstrated the spherical droplets morphology in nanometer range. The globule average diameter size was 45 nm. The SNEDDS formulation significantly increase dissolution of glimepiride compared with pure drug.http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/7387/pdf_59SNEDDSglimepirideoleic aciddissolution |
| spellingShingle | Sani Ega Priani Nurrayyan Fitrianti Darusman Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase Pharmaciana SNEDDS glimepiride oleic acid dissolution |
| title | Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase |
| title_full | Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase |
| title_fullStr | Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase |
| title_full_unstemmed | Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase |
| title_short | Formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase |
| title_sort | formulation self nano emulsifying drug delivery system glimepiride using oleic acid as oil phase |
| topic | SNEDDS glimepiride oleic acid dissolution |
| url | http://journal.uad.ac.id/index.php/PHARMACIANA/article/view/7387/pdf_59 |
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