Case report: Injected corticosteroids for treating leprosy isolated neuritis
One of the main manifestations of leprosy is peripheral nerve impairment. Early diagnosis and treatment are important to reduce the impact of neurological impairment, which can cause deformities and physical disabilities. Leprosy neuropathy can be acute or chronic, and neural involvement can occur b...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1202108/full |
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| author | Clarissa Neves Spitz Clarissa Neves Spitz Clarissa Neves Spitz Izabela Jardim Rodrigues Pitta Izabela Jardim Rodrigues Pitta Ligia Rocha Andrade Ligia Rocha Andrade Ligia Rocha Andrade Anna Maria Sales Euzenir Nunes Sarno Nivaldo Ribeiro Villela Roberta Olmo Pinheiro Roberta Olmo Pinheiro Marcia Rodrigues Jardim Marcia Rodrigues Jardim Marcia Rodrigues Jardim Marcia Rodrigues Jardim |
| author_facet | Clarissa Neves Spitz Clarissa Neves Spitz Clarissa Neves Spitz Izabela Jardim Rodrigues Pitta Izabela Jardim Rodrigues Pitta Ligia Rocha Andrade Ligia Rocha Andrade Ligia Rocha Andrade Anna Maria Sales Euzenir Nunes Sarno Nivaldo Ribeiro Villela Roberta Olmo Pinheiro Roberta Olmo Pinheiro Marcia Rodrigues Jardim Marcia Rodrigues Jardim Marcia Rodrigues Jardim Marcia Rodrigues Jardim |
| author_sort | Clarissa Neves Spitz |
| collection | DOAJ |
| description | One of the main manifestations of leprosy is peripheral nerve impairment. Early diagnosis and treatment are important to reduce the impact of neurological impairment, which can cause deformities and physical disabilities. Leprosy neuropathy can be acute or chronic, and neural involvement can occur before, during, or after multidrug therapy, and especially during reactional episodes when neuritis occurs. Neuritis causes loss of function in the nerves and can be irreversible if left untreated. The recommended treatment is corticosteroids, usually through an oral regimen at an immunosuppressive dose. However, patients with clinical conditions that restrict corticosteroid use or that have focal neural involvement may benefit from the use of ultrasound-guided perineural injectable corticosteroids. In this study, we report two cases that demonstrate how the treatment and follow-up of patients with neuritis secondary to leprosy, using new techniques, can be provided in a more individualized way. Nerve conduction studies in association with neuromuscular ultrasound were used to monitor the response to treatment with injected steroids, focusing on neural inflammation. This study provides new perspectives and options for this profile of patients. |
| first_indexed | 2024-03-13T05:05:31Z |
| format | Article |
| id | doaj.art-190c811dd02c4c4f9ab35b5fc56b1c0d |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-13T05:05:31Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-190c811dd02c4c4f9ab35b5fc56b1c0d2023-06-16T13:18:14ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-06-011010.3389/fmed.2023.12021081202108Case report: Injected corticosteroids for treating leprosy isolated neuritisClarissa Neves Spitz0Clarissa Neves Spitz1Clarissa Neves Spitz2Izabela Jardim Rodrigues Pitta3Izabela Jardim Rodrigues Pitta4Ligia Rocha Andrade5Ligia Rocha Andrade6Ligia Rocha Andrade7Anna Maria Sales8Euzenir Nunes Sarno9Nivaldo Ribeiro Villela10Roberta Olmo Pinheiro11Roberta Olmo Pinheiro12Marcia Rodrigues Jardim13Marcia Rodrigues Jardim14Marcia Rodrigues Jardim15Marcia Rodrigues Jardim16Leprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilPost-Graduate Program in Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, BrazilPedro Ernesto University Hospital, Rio de Janeiro State University, Rio de Janeiro, BrazilLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilDepartment of Neurology, Antonio Pedro University Hospital, Fluminense Federal University, Niteroi, BrazilLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilPost-Graduate Program in Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, BrazilPedro Ernesto University Hospital, Rio de Janeiro State University, Rio de Janeiro, BrazilLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilPedro Ernesto University Hospital, Rio de Janeiro State University, Rio de Janeiro, BrazilLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilNational Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilLeprosy Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilPost-Graduate Program in Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, BrazilPedro Ernesto University Hospital, Rio de Janeiro State University, Rio de Janeiro, BrazilNational Institute of Science and Technology on Neuroimmunomodulation, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, BrazilOne of the main manifestations of leprosy is peripheral nerve impairment. Early diagnosis and treatment are important to reduce the impact of neurological impairment, which can cause deformities and physical disabilities. Leprosy neuropathy can be acute or chronic, and neural involvement can occur before, during, or after multidrug therapy, and especially during reactional episodes when neuritis occurs. Neuritis causes loss of function in the nerves and can be irreversible if left untreated. The recommended treatment is corticosteroids, usually through an oral regimen at an immunosuppressive dose. However, patients with clinical conditions that restrict corticosteroid use or that have focal neural involvement may benefit from the use of ultrasound-guided perineural injectable corticosteroids. In this study, we report two cases that demonstrate how the treatment and follow-up of patients with neuritis secondary to leprosy, using new techniques, can be provided in a more individualized way. Nerve conduction studies in association with neuromuscular ultrasound were used to monitor the response to treatment with injected steroids, focusing on neural inflammation. This study provides new perspectives and options for this profile of patients.https://www.frontiersin.org/articles/10.3389/fmed.2023.1202108/fullleprosyultrasoundcorticosteroidcase reportneuritis |
| spellingShingle | Clarissa Neves Spitz Clarissa Neves Spitz Clarissa Neves Spitz Izabela Jardim Rodrigues Pitta Izabela Jardim Rodrigues Pitta Ligia Rocha Andrade Ligia Rocha Andrade Ligia Rocha Andrade Anna Maria Sales Euzenir Nunes Sarno Nivaldo Ribeiro Villela Roberta Olmo Pinheiro Roberta Olmo Pinheiro Marcia Rodrigues Jardim Marcia Rodrigues Jardim Marcia Rodrigues Jardim Marcia Rodrigues Jardim Case report: Injected corticosteroids for treating leprosy isolated neuritis Frontiers in Medicine leprosy ultrasound corticosteroid case report neuritis |
| title | Case report: Injected corticosteroids for treating leprosy isolated neuritis |
| title_full | Case report: Injected corticosteroids for treating leprosy isolated neuritis |
| title_fullStr | Case report: Injected corticosteroids for treating leprosy isolated neuritis |
| title_full_unstemmed | Case report: Injected corticosteroids for treating leprosy isolated neuritis |
| title_short | Case report: Injected corticosteroids for treating leprosy isolated neuritis |
| title_sort | case report injected corticosteroids for treating leprosy isolated neuritis |
| topic | leprosy ultrasound corticosteroid case report neuritis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1202108/full |
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