The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma
Progression from asymptomatic smoldering multiple myeloma (SMM) to symptomatic Multiple Myeloma occurs at different rates in different patients. Here, the authors report fewer NRAS and FAM46C mutations and adverse translocations in SMM compared to MM, while KRAS mutations are associated with a short...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20524-2 |
| _version_ | 1818429159379042304 |
|---|---|
| author | Eileen M. Boyle Shayu Deshpande Ruslana Tytarenko Cody Ashby Yan Wang Michael A. Bauer Sarah K. Johnson Christopher P. Wardell Sharmilan Thanendrarajan Maurizio Zangari Thierry Facon Charles Dumontet Bart Barlogie Arnaldo Arbini Even H. Rustad Francesco Maura Ola Landgren Fenghuang Zhan Frits van Rhee Carolina Schinke Faith E. Davies Gareth J. Morgan Brian A. Walker |
| author_facet | Eileen M. Boyle Shayu Deshpande Ruslana Tytarenko Cody Ashby Yan Wang Michael A. Bauer Sarah K. Johnson Christopher P. Wardell Sharmilan Thanendrarajan Maurizio Zangari Thierry Facon Charles Dumontet Bart Barlogie Arnaldo Arbini Even H. Rustad Francesco Maura Ola Landgren Fenghuang Zhan Frits van Rhee Carolina Schinke Faith E. Davies Gareth J. Morgan Brian A. Walker |
| author_sort | Eileen M. Boyle |
| collection | DOAJ |
| description | Progression from asymptomatic smoldering multiple myeloma (SMM) to symptomatic Multiple Myeloma occurs at different rates in different patients. Here, the authors report fewer NRAS and FAM46C mutations and adverse translocations in SMM compared to MM, while KRAS mutations are associated with a shorter time to progression. |
| first_indexed | 2024-12-14T15:13:05Z |
| format | Article |
| id | doaj.art-190cc8a591d94b4a813749741597a52e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T15:13:05Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-190cc8a591d94b4a813749741597a52e2022-12-21T22:56:28ZengNature PortfolioNature Communications2041-17232021-01-0112111310.1038/s41467-020-20524-2The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myelomaEileen M. Boyle0Shayu Deshpande1Ruslana Tytarenko2Cody Ashby3Yan Wang4Michael A. Bauer5Sarah K. Johnson6Christopher P. Wardell7Sharmilan Thanendrarajan8Maurizio Zangari9Thierry Facon10Charles Dumontet11Bart Barlogie12Arnaldo Arbini13Even H. Rustad14Francesco Maura15Ola Landgren16Fenghuang Zhan17Frits van Rhee18Carolina Schinke19Faith E. Davies20Gareth J. Morgan21Brian A. Walker22Myeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesService des maladies du sang. Hôpital Claude Huriez, Lille University HospitalINSERM 1052/CNRS 5286 Cancer Research Center of LyonDivision of Hematology, The Mount Sinai HospitalPerlmutter Cancer Center, NYU Langone HealthPerlmutter Cancer Center, NYU Langone HealthMyeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer CenterMyeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer CenterMyeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesMyeloma Center, University of Arkansas for Medical SciencesPerlmutter Cancer Center, NYU Langone HealthPerlmutter Cancer Center, NYU Langone HealthDivision of Hematology Oncology, Indiana UniversityProgression from asymptomatic smoldering multiple myeloma (SMM) to symptomatic Multiple Myeloma occurs at different rates in different patients. Here, the authors report fewer NRAS and FAM46C mutations and adverse translocations in SMM compared to MM, while KRAS mutations are associated with a shorter time to progression.https://doi.org/10.1038/s41467-020-20524-2 |
| spellingShingle | Eileen M. Boyle Shayu Deshpande Ruslana Tytarenko Cody Ashby Yan Wang Michael A. Bauer Sarah K. Johnson Christopher P. Wardell Sharmilan Thanendrarajan Maurizio Zangari Thierry Facon Charles Dumontet Bart Barlogie Arnaldo Arbini Even H. Rustad Francesco Maura Ola Landgren Fenghuang Zhan Frits van Rhee Carolina Schinke Faith E. Davies Gareth J. Morgan Brian A. Walker The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma Nature Communications |
| title | The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma |
| title_full | The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma |
| title_fullStr | The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma |
| title_full_unstemmed | The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma |
| title_short | The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma |
| title_sort | molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma |
| url | https://doi.org/10.1038/s41467-020-20524-2 |
| work_keys_str_mv | AT eileenmboyle themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT shayudeshpande themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT ruslanatytarenko themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT codyashby themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT yanwang themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT michaelabauer themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT sarahkjohnson themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT christopherpwardell themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT sharmilanthanendrarajan themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT mauriziozangari themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT thierryfacon themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT charlesdumontet themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT bartbarlogie themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT arnaldoarbini themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT evenhrustad themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT francescomaura themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT olalandgren themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT fenghuangzhan themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT fritsvanrhee themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT carolinaschinke themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT faithedavies themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT garethjmorgan themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT brianawalker themolecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT eileenmboyle molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT shayudeshpande molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT ruslanatytarenko molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT codyashby molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT yanwang molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT michaelabauer molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT sarahkjohnson molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT christopherpwardell molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT sharmilanthanendrarajan molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT mauriziozangari molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT thierryfacon molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT charlesdumontet molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT bartbarlogie molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT arnaldoarbini molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT evenhrustad molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT francescomaura molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT olalandgren molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT fenghuangzhan molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT fritsvanrhee molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT carolinaschinke molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT faithedavies molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT garethjmorgan molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma AT brianawalker molecularmakeupofsmolderingmyelomahighlightstheevolutionarypathwaysleadingtomultiplemyeloma |