Ischemic Stroke and Savings in Time to Achieve Functional Recovery: Experience from NeuroAiD
Despite recent progress with revascularisation interventions after acute ischemic stroke, many patients remain disabled after stroke. Using data from a multi-centre, randomised, double-blind, placebo-controlled trial of a neuro-repair treatment (NeuroAiD/MLC601) with a long-term follow-up, we analys...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/10/3/117 |
| _version_ | 1797610997785034752 |
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| author | Narayanaswamy Venketasubramanian Yogesh Pokharkar Jia Hui Chai Christopher Li Hsian Chen |
| author_facet | Narayanaswamy Venketasubramanian Yogesh Pokharkar Jia Hui Chai Christopher Li Hsian Chen |
| author_sort | Narayanaswamy Venketasubramanian |
| collection | DOAJ |
| description | Despite recent progress with revascularisation interventions after acute ischemic stroke, many patients remain disabled after stroke. Using data from a multi-centre, randomised, double-blind, placebo-controlled trial of a neuro-repair treatment (NeuroAiD/MLC601) with a long-term follow-up, we analysed the savings in time to functional recovery, measured by a modified Rankin Scale (mRS) score of 0 or 1, in patients receiving a 3-month oral course of MLC601. Analysis of time to recovery was assessed by a log-rank test and hazard ratios (HRs) adjusted for prognosis factors. A total of 548 patients with baseline NIHSS scores 8–14, mRS scores ≥ 2 at day 10 post-stroke, and at least one mRS assessment on or after month 1 were included in the analysis (placebo = 261; MLC601 = 287). Time to functional recovery was significantly shortened for patients receiving MLC601 versus patients receiving placebo (log-rank test: <i>p</i> = 0.039). This result was confirmed by Cox regression adjusting for the main baseline prognostic factors (HR: 1.30 [0.99, 1.70]; <i>p</i> = 0.059) and was more pronounced in patients with additional poor prognosis factors. The Kaplan–Meier plot showed that approximately 40% cumulative incidence of functional recovery was achieved within 6 months after stroke onset in the MLC601 group versus 24 months in the placebo group. The main findings are that MLC601 reduced the time to achieve functional recovery, and a 40% functional recovery rate was achieved 18 months earlier compared to placebo. |
| first_indexed | 2024-03-11T06:22:45Z |
| format | Article |
| id | doaj.art-190cfd4b24c149fcad67634406f75eb8 |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-11T06:22:45Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-190cfd4b24c149fcad67634406f75eb82023-11-17T11:47:39ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-03-0110311710.3390/jcdd10030117Ischemic Stroke and Savings in Time to Achieve Functional Recovery: Experience from NeuroAiDNarayanaswamy Venketasubramanian0Yogesh Pokharkar1Jia Hui Chai2Christopher Li Hsian Chen3Raffles Neuroscience Centre, Raffles Hospital, Singapore 188770, SingaporeSingapore Clinical Research Institute, Consortium for Clinical Research and Innovation Singapore, 23 Rochester Park, Singapore 139234, SingaporeSingapore Clinical Research Institute, Consortium for Clinical Research and Innovation Singapore, 23 Rochester Park, Singapore 139234, SingaporeMemory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, SingaporeDespite recent progress with revascularisation interventions after acute ischemic stroke, many patients remain disabled after stroke. Using data from a multi-centre, randomised, double-blind, placebo-controlled trial of a neuro-repair treatment (NeuroAiD/MLC601) with a long-term follow-up, we analysed the savings in time to functional recovery, measured by a modified Rankin Scale (mRS) score of 0 or 1, in patients receiving a 3-month oral course of MLC601. Analysis of time to recovery was assessed by a log-rank test and hazard ratios (HRs) adjusted for prognosis factors. A total of 548 patients with baseline NIHSS scores 8–14, mRS scores ≥ 2 at day 10 post-stroke, and at least one mRS assessment on or after month 1 were included in the analysis (placebo = 261; MLC601 = 287). Time to functional recovery was significantly shortened for patients receiving MLC601 versus patients receiving placebo (log-rank test: <i>p</i> = 0.039). This result was confirmed by Cox regression adjusting for the main baseline prognostic factors (HR: 1.30 [0.99, 1.70]; <i>p</i> = 0.059) and was more pronounced in patients with additional poor prognosis factors. The Kaplan–Meier plot showed that approximately 40% cumulative incidence of functional recovery was achieved within 6 months after stroke onset in the MLC601 group versus 24 months in the placebo group. The main findings are that MLC601 reduced the time to achieve functional recovery, and a 40% functional recovery rate was achieved 18 months earlier compared to placebo.https://www.mdpi.com/2308-3425/10/3/117MLC601NeuroAiDfunctional recoverystroketime to recovery |
| spellingShingle | Narayanaswamy Venketasubramanian Yogesh Pokharkar Jia Hui Chai Christopher Li Hsian Chen Ischemic Stroke and Savings in Time to Achieve Functional Recovery: Experience from NeuroAiD Journal of Cardiovascular Development and Disease MLC601 NeuroAiD functional recovery stroke time to recovery |
| title | Ischemic Stroke and Savings in Time to Achieve Functional Recovery: Experience from NeuroAiD |
| title_full | Ischemic Stroke and Savings in Time to Achieve Functional Recovery: Experience from NeuroAiD |
| title_fullStr | Ischemic Stroke and Savings in Time to Achieve Functional Recovery: Experience from NeuroAiD |
| title_full_unstemmed | Ischemic Stroke and Savings in Time to Achieve Functional Recovery: Experience from NeuroAiD |
| title_short | Ischemic Stroke and Savings in Time to Achieve Functional Recovery: Experience from NeuroAiD |
| title_sort | ischemic stroke and savings in time to achieve functional recovery experience from neuroaid |
| topic | MLC601 NeuroAiD functional recovery stroke time to recovery |
| url | https://www.mdpi.com/2308-3425/10/3/117 |
| work_keys_str_mv | AT narayanaswamyvenketasubramanian ischemicstrokeandsavingsintimetoachievefunctionalrecoveryexperiencefromneuroaid AT yogeshpokharkar ischemicstrokeandsavingsintimetoachievefunctionalrecoveryexperiencefromneuroaid AT jiahuichai ischemicstrokeandsavingsintimetoachievefunctionalrecoveryexperiencefromneuroaid AT christopherlihsianchen ischemicstrokeandsavingsintimetoachievefunctionalrecoveryexperiencefromneuroaid |