Towards infant formula biomimetic of human milk structure and digestive behaviour
Lipids of human milk or infant formula convey most of the energy necessary to support the newborn growth. Until recently, infant formula chemical composition had been optimized but not their structure. And yet, more and more proofs of evidence have shown that lipids structure in human milk modulates...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2017-03-01
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| Series: | Oilseeds and fats, crops and lipids |
| Subjects: | |
| Online Access: | https://doi.org/10.1051/ocl/2017010 |
| _version_ | 1818615970293350400 |
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| author | Bourlieu Claire Deglaire Amélie de Oliveira Samira Cassia Ménard Olivia Le Gouar Yann Carrière Frédéric Dupont Didier |
| author_facet | Bourlieu Claire Deglaire Amélie de Oliveira Samira Cassia Ménard Olivia Le Gouar Yann Carrière Frédéric Dupont Didier |
| author_sort | Bourlieu Claire |
| collection | DOAJ |
| description | Lipids of human milk or infant formula convey most of the energy necessary to support the newborn growth. Until recently, infant formula chemical composition had been optimized but not their structure. And yet, more and more proofs of evidence have shown that lipids structure in human milk modulates digestion kinetics and is involved in metabolic programming. Indeed there is a striking difference of structure between human milk which is an emulsion based on dispersed milk fat globules (4 μm) secreted by the mammary gland and submicronic neoformed lipid droplets (0.5 μm) found in infant formula. These droplets result from a series of operation units. This difference of structure modifies digestion kinetics and emulsion disintegration in the intestinal tract of the newborn. This difference persists along gastric phase which is mainly dominated by acid and enzyme-induced aggregation. Lipid droplets size is thus the key parameter to control gastric lipolysis and emptying and intestinal lipolysis. This parameter also controls proteolysis since adsorbed proteins are more rapidly hydrolyzed than when in solution. In animal models, these differences of lipid structure would also impact digestive and immune systems' maturation and microbiota. Lipid structure during neonatal period would also be involved in the early programming of adipose tissues and metabolism. The supplementation of infant formulas with bovine milk fractions (milk fat globule membrane extracts, triacylglycerol) or recent development of large droplets infant formula, along with new fields of innovation in neonatal nutrition, are here reviewed. |
| first_indexed | 2024-12-16T16:42:22Z |
| format | Article |
| id | doaj.art-190e6432e48546c79c02eee65bf02685 |
| institution | Directory Open Access Journal |
| issn | 2272-6977 2257-6614 |
| language | English |
| last_indexed | 2024-12-16T16:42:22Z |
| publishDate | 2017-03-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Oilseeds and fats, crops and lipids |
| spelling | doaj.art-190e6432e48546c79c02eee65bf026852022-12-21T22:24:15ZengEDP SciencesOilseeds and fats, crops and lipids2272-69772257-66142017-03-01242D20610.1051/ocl/2017010ocl170004Towards infant formula biomimetic of human milk structure and digestive behaviourBourlieu ClaireDeglaire Améliede Oliveira Samira CassiaMénard OliviaLe Gouar YannCarrière FrédéricDupont DidierLipids of human milk or infant formula convey most of the energy necessary to support the newborn growth. Until recently, infant formula chemical composition had been optimized but not their structure. And yet, more and more proofs of evidence have shown that lipids structure in human milk modulates digestion kinetics and is involved in metabolic programming. Indeed there is a striking difference of structure between human milk which is an emulsion based on dispersed milk fat globules (4 μm) secreted by the mammary gland and submicronic neoformed lipid droplets (0.5 μm) found in infant formula. These droplets result from a series of operation units. This difference of structure modifies digestion kinetics and emulsion disintegration in the intestinal tract of the newborn. This difference persists along gastric phase which is mainly dominated by acid and enzyme-induced aggregation. Lipid droplets size is thus the key parameter to control gastric lipolysis and emptying and intestinal lipolysis. This parameter also controls proteolysis since adsorbed proteins are more rapidly hydrolyzed than when in solution. In animal models, these differences of lipid structure would also impact digestive and immune systems' maturation and microbiota. Lipid structure during neonatal period would also be involved in the early programming of adipose tissues and metabolism. The supplementation of infant formulas with bovine milk fractions (milk fat globule membrane extracts, triacylglycerol) or recent development of large droplets infant formula, along with new fields of innovation in neonatal nutrition, are here reviewed.https://doi.org/10.1051/ocl/2017010human milk fat globuleslipid structureinfant formulaneonatal digestionprogramming |
| spellingShingle | Bourlieu Claire Deglaire Amélie de Oliveira Samira Cassia Ménard Olivia Le Gouar Yann Carrière Frédéric Dupont Didier Towards infant formula biomimetic of human milk structure and digestive behaviour Oilseeds and fats, crops and lipids human milk fat globules lipid structure infant formula neonatal digestion programming |
| title | Towards infant formula biomimetic of human milk structure and digestive behaviour |
| title_full | Towards infant formula biomimetic of human milk structure and digestive behaviour |
| title_fullStr | Towards infant formula biomimetic of human milk structure and digestive behaviour |
| title_full_unstemmed | Towards infant formula biomimetic of human milk structure and digestive behaviour |
| title_short | Towards infant formula biomimetic of human milk structure and digestive behaviour |
| title_sort | towards infant formula biomimetic of human milk structure and digestive behaviour |
| topic | human milk fat globules lipid structure infant formula neonatal digestion programming |
| url | https://doi.org/10.1051/ocl/2017010 |
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