Modeling the ACVR1R206H mutation in human skeletal muscle stem cells

Modeling the ACVR1R206H mutation in human skeletal muscle stem cells

Abnormalities in skeletal muscle repair can lead to poor function and complications such as scarring or heterotopic ossification (HO). Here, we use fibrodysplasia ossificans progressiva (FOP), a disease of progressive HO caused by ACVR1R206H (Activin receptor type-1 receptor) mutation, to elucidate...

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Bibliographic Details
Main Authors: Emilie Barruet, Steven M Garcia, Jake Wu, Blanca M Morales, Stanley Tamaki, Tania Moody, Jason H Pomerantz, Edward C Hsiao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-11-01
Series:eLife
Subjects:
human satellite cells hu-SCs
human muscle stem cells hu-MuSCs
human induced pluripotent stem cells iPSCs
ACVR1
heterotopic ossification
fibrodysplasia ossificans progressivav FOP
Online Access:https://elifesciences.org/articles/66107

Internet

https://elifesciences.org/articles/66107

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