Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations
Summary: Recent identification of a mammary gland-specific microbiome led to studies investigating bacteria populations in breast cancer. Malignant breast tumors have lower Lactobacillus abundance compared with benign lesions, implicating Lactobacillus as a negative regulator of breast cancer. Diet...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-10-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124718313822 |
| _version_ | 1818143144866217984 |
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| author | Carol A. Shively Thomas C. Register Susan E. Appt Thomas B. Clarkson Beth Uberseder Kenysha Y.J. Clear Adam S. Wilson Akiko Chiba Janet A. Tooze Katherine L. Cook |
| author_facet | Carol A. Shively Thomas C. Register Susan E. Appt Thomas B. Clarkson Beth Uberseder Kenysha Y.J. Clear Adam S. Wilson Akiko Chiba Janet A. Tooze Katherine L. Cook |
| author_sort | Carol A. Shively |
| collection | DOAJ |
| description | Summary: Recent identification of a mammary gland-specific microbiome led to studies investigating bacteria populations in breast cancer. Malignant breast tumors have lower Lactobacillus abundance compared with benign lesions, implicating Lactobacillus as a negative regulator of breast cancer. Diet is a main determinant of gut microbial diversity. Whether diet affects breast microbiome populations is unknown. In a non-human primate model, we found that consumption of a Western or Mediterranean diet modulated mammary gland microbiota and metabolite profiles. Mediterranean diet consumption led to increased mammary gland Lactobacillus abundance compared with Western diet-fed monkeys. Moreover, mammary glands from Mediterranean diet-fed monkeys had higher levels of bile acid metabolites and increased bacterial-processed bioactive compounds. These data suggest that diet directly influences microbiome populations outside the intestinal tract in distal sites such as the mammary gland. Our study demonstrates that diet affects the mammary gland microbiome, establishing an alternative mechanistic pathway for breast cancer prevention. : Using a non-human primate model of women’s health, Shively et al. demonstrate that diet plays a critical role in determining microbiota populations in tissues outside the gut, such as the mammary gland. These microbial populations modulate localized bile acid and bacterial-modified metabolites to potentially influence anticancer signaling pathways. Keywords: breast, mammary gland, diet, microbiome, bile acid, hippurate, oxidative stress |
| first_indexed | 2024-12-11T11:27:00Z |
| format | Article |
| id | doaj.art-191077a29093483eadc9546181b01aaa |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-11T11:27:00Z |
| publishDate | 2018-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-191077a29093483eadc9546181b01aaa2022-12-22T01:08:59ZengElsevierCell Reports2211-12472018-10-012514756.e3Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome PopulationsCarol A. Shively0Thomas C. Register1Susan E. Appt2Thomas B. Clarkson3Beth Uberseder4Kenysha Y.J. Clear5Adam S. Wilson6Akiko Chiba7Janet A. Tooze8Katherine L. Cook9Department of Pathology, Section of Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USADepartment of Pathology, Section of Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USADepartment of Pathology, Section of Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC 27157, USADepartment of Pathology, Section of Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USADepartment of Pathology, Section of Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USADepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC 27157, USADepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC 27157, USADepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC 27157, USADepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USADepartment of Surgery, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Corresponding authorSummary: Recent identification of a mammary gland-specific microbiome led to studies investigating bacteria populations in breast cancer. Malignant breast tumors have lower Lactobacillus abundance compared with benign lesions, implicating Lactobacillus as a negative regulator of breast cancer. Diet is a main determinant of gut microbial diversity. Whether diet affects breast microbiome populations is unknown. In a non-human primate model, we found that consumption of a Western or Mediterranean diet modulated mammary gland microbiota and metabolite profiles. Mediterranean diet consumption led to increased mammary gland Lactobacillus abundance compared with Western diet-fed monkeys. Moreover, mammary glands from Mediterranean diet-fed monkeys had higher levels of bile acid metabolites and increased bacterial-processed bioactive compounds. These data suggest that diet directly influences microbiome populations outside the intestinal tract in distal sites such as the mammary gland. Our study demonstrates that diet affects the mammary gland microbiome, establishing an alternative mechanistic pathway for breast cancer prevention. : Using a non-human primate model of women’s health, Shively et al. demonstrate that diet plays a critical role in determining microbiota populations in tissues outside the gut, such as the mammary gland. These microbial populations modulate localized bile acid and bacterial-modified metabolites to potentially influence anticancer signaling pathways. Keywords: breast, mammary gland, diet, microbiome, bile acid, hippurate, oxidative stresshttp://www.sciencedirect.com/science/article/pii/S2211124718313822 |
| spellingShingle | Carol A. Shively Thomas C. Register Susan E. Appt Thomas B. Clarkson Beth Uberseder Kenysha Y.J. Clear Adam S. Wilson Akiko Chiba Janet A. Tooze Katherine L. Cook Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations Cell Reports |
| title | Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations |
| title_full | Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations |
| title_fullStr | Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations |
| title_full_unstemmed | Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations |
| title_short | Consumption of Mediterranean versus Western Diet Leads to Distinct Mammary Gland Microbiome Populations |
| title_sort | consumption of mediterranean versus western diet leads to distinct mammary gland microbiome populations |
| url | http://www.sciencedirect.com/science/article/pii/S2211124718313822 |
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