RAD52: Viral Friend or Foe?
Mammalian Radiation Sensitive 52 (<i>RAD52</i>) is a gene whose scientific reputation has recently seen a strong resurgence. In the past decade, RAD52, which was thought to be dispensable for most DNA repair and recombination reactions in mammals, has been shown to be important for a bev...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/2/399 |
| _version_ | 1797708984452382720 |
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| author | Eric A. Hendrickson |
| author_facet | Eric A. Hendrickson |
| author_sort | Eric A. Hendrickson |
| collection | DOAJ |
| description | Mammalian Radiation Sensitive 52 (<i>RAD52</i>) is a gene whose scientific reputation has recently seen a strong resurgence. In the past decade, RAD52, which was thought to be dispensable for most DNA repair and recombination reactions in mammals, has been shown to be important for a bevy of DNA metabolic pathways. One of these processes is termed break-induced replication (BIR), a mechanism that can be used to re-start broken replication forks and to elongate the ends of chromosomes in telomerase-negative cells. Viruses have historically evolved a myriad of mechanisms in which they either conscript cellular factors or, more frequently, inactivate them as a means to enable their own replication and survival. Recent data suggests that Adeno-Associated Virus (AAV) may replicate its DNA in a BIR-like fashion and/or utilize RAD52 to facilitate viral transduction and, as such, likely conscripts/requires the host RAD52 protein to promote its perpetuation. |
| first_indexed | 2024-03-12T06:29:39Z |
| format | Article |
| id | doaj.art-1910d070cf3443c6ba68742f69a01136 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:29:39Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-1910d070cf3443c6ba68742f69a011362023-09-03T01:39:31ZengMDPI AGCancers2072-66942020-02-0112239910.3390/cancers12020399cancers12020399RAD52: Viral Friend or Foe?Eric A. Hendrickson0Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Medical School, 6-155 Jackson Hall, 321 Church St., SE., Minneapolis, MN 55455, USAMammalian Radiation Sensitive 52 (<i>RAD52</i>) is a gene whose scientific reputation has recently seen a strong resurgence. In the past decade, RAD52, which was thought to be dispensable for most DNA repair and recombination reactions in mammals, has been shown to be important for a bevy of DNA metabolic pathways. One of these processes is termed break-induced replication (BIR), a mechanism that can be used to re-start broken replication forks and to elongate the ends of chromosomes in telomerase-negative cells. Viruses have historically evolved a myriad of mechanisms in which they either conscript cellular factors or, more frequently, inactivate them as a means to enable their own replication and survival. Recent data suggests that Adeno-Associated Virus (AAV) may replicate its DNA in a BIR-like fashion and/or utilize RAD52 to facilitate viral transduction and, as such, likely conscripts/requires the host RAD52 protein to promote its perpetuation.https://www.mdpi.com/2072-6694/12/2/399rad52break-induced replicationbirsingle-strand annealingssaalternative non-homologous end joininga-nhejadeno-associated virusaavhuman immunodeficiency virushivherpes simplex virushsv |
| spellingShingle | Eric A. Hendrickson RAD52: Viral Friend or Foe? Cancers rad52 break-induced replication bir single-strand annealing ssa alternative non-homologous end joining a-nhej adeno-associated virus aav human immunodeficiency virus hiv herpes simplex virus hsv |
| title | RAD52: Viral Friend or Foe? |
| title_full | RAD52: Viral Friend or Foe? |
| title_fullStr | RAD52: Viral Friend or Foe? |
| title_full_unstemmed | RAD52: Viral Friend or Foe? |
| title_short | RAD52: Viral Friend or Foe? |
| title_sort | rad52 viral friend or foe |
| topic | rad52 break-induced replication bir single-strand annealing ssa alternative non-homologous end joining a-nhej adeno-associated virus aav human immunodeficiency virus hiv herpes simplex virus hsv |
| url | https://www.mdpi.com/2072-6694/12/2/399 |
| work_keys_str_mv | AT ericahendrickson rad52viralfriendorfoe |