Complement and CD4+ T cells drive context-specific corneal sensory neuropathy

Complement and CD4+ T cells drive context-specific corneal sensory neuropathy

Whether complement dysregulation directly contributes to the pathogenesis of peripheral nervous system diseases, including sensory neuropathies, is unclear. We addressed this important question in a mouse model of ocular HSV-1 infection, where sensory nerve damage is a common clinical problem. Throu...

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Bibliographic Details
Main Authors: Derek J Royer, Jose Echegaray-Mendez, Liwen Lin, Grzegorz B Gmyrek, Rose Mathew, Daniel R Saban, Victor L Perez, Daniel JJ Carr
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
cornea
neuropathy
inflammation
HSV-1
graft vs. host disease
complement
Online Access:https://elifesciences.org/articles/48378

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