Epigenetic Modifications in Pediatric Acute Lymphoblastic Leukemia
Aberrant epigenetic modifications are well-recognized drivers for oncogenesis. Pediatric acute lymphoblastic leukemia (ALL) is no exception and serves as a model toward the significant impact these heritable alterations can have in leukemogenesis. In this brief review, we will focus on the main aspe...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-05-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fped.2014.00042/full |
| _version_ | 1818542177609842688 |
|---|---|
| author | Michael James Burke Teena eBhatla |
| author_facet | Michael James Burke Teena eBhatla |
| author_sort | Michael James Burke |
| collection | DOAJ |
| description | Aberrant epigenetic modifications are well-recognized drivers for oncogenesis. Pediatric acute lymphoblastic leukemia (ALL) is no exception and serves as a model toward the significant impact these heritable alterations can have in leukemogenesis. In this brief review, we will focus on the main aspects of epigenetics which control leukemogenesis in pediatric ALL, mainly DNA methylation, histone modification and microRNA alterations. As we continue to gain better understanding of the driving mechanisms for pediatric ALL at both diagnosis and relapse, therapeutic interventions directed toward these pathways and mechanisms can be harnessed and introduced into clinical trials for pediatric ALL. |
| first_indexed | 2024-12-11T22:18:42Z |
| format | Article |
| id | doaj.art-191924c41bcc4e5f9ebd41a8d7bfde76 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-11T22:18:42Z |
| publishDate | 2014-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-191924c41bcc4e5f9ebd41a8d7bfde762022-12-22T00:48:30ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602014-05-01210.3389/fped.2014.0004282871Epigenetic Modifications in Pediatric Acute Lymphoblastic LeukemiaMichael James Burke0Teena eBhatla1Medical College of WisconsinNew York UniversityAberrant epigenetic modifications are well-recognized drivers for oncogenesis. Pediatric acute lymphoblastic leukemia (ALL) is no exception and serves as a model toward the significant impact these heritable alterations can have in leukemogenesis. In this brief review, we will focus on the main aspects of epigenetics which control leukemogenesis in pediatric ALL, mainly DNA methylation, histone modification and microRNA alterations. As we continue to gain better understanding of the driving mechanisms for pediatric ALL at both diagnosis and relapse, therapeutic interventions directed toward these pathways and mechanisms can be harnessed and introduced into clinical trials for pediatric ALL.http://journal.frontiersin.org/Journal/10.3389/fped.2014.00042/fullLeukemiaMethylationepigeneticshistoneALLpediatric |
| spellingShingle | Michael James Burke Teena eBhatla Epigenetic Modifications in Pediatric Acute Lymphoblastic Leukemia Frontiers in Pediatrics Leukemia Methylation epigenetics histone ALL pediatric |
| title | Epigenetic Modifications in Pediatric Acute Lymphoblastic Leukemia |
| title_full | Epigenetic Modifications in Pediatric Acute Lymphoblastic Leukemia |
| title_fullStr | Epigenetic Modifications in Pediatric Acute Lymphoblastic Leukemia |
| title_full_unstemmed | Epigenetic Modifications in Pediatric Acute Lymphoblastic Leukemia |
| title_short | Epigenetic Modifications in Pediatric Acute Lymphoblastic Leukemia |
| title_sort | epigenetic modifications in pediatric acute lymphoblastic leukemia |
| topic | Leukemia Methylation epigenetics histone ALL pediatric |
| url | http://journal.frontiersin.org/Journal/10.3389/fped.2014.00042/full |
| work_keys_str_mv | AT michaeljamesburke epigeneticmodificationsinpediatricacutelymphoblasticleukemia AT teenaebhatla epigeneticmodificationsinpediatricacutelymphoblasticleukemia |